Basic Information:

  VIRBase ID:  

HHID00014668

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365a-5p:  MIMAT0009199          IL21R:  NM_181078     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-365a-5p	IL21R
miRBase Accession/Entrez ID	MIMAT0009199	50615
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CD360//IMD56//NILR

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-365a-5p	rs1166908611 chr16:14309308    T/C rs1368596991 chr16:14309314    G/A rs1380926089 chr16:14309318    A/G rs1396179427 chr16:14309310    G/C rs1428928383 chr16:14309320    G/A rs773834113 chr16:14309301    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	IL21R	chr16:27451818(+) A-I      intronic chr16:27422923(+) A-I      intronic chr16:27441977(+) A-I      intronic chr16:27446320(+) A-I      intronic chr16:27446892(+) A-I      intronic chr16:27447121(+) A-I      intronic chr16:27447169(+) A-I      intronic chr16:27427639(+) A-I      intronic chr16:27447193(+) A-I      intronic chr16:27447208(+) A-I      intronic chr16:27440838(+) A-I      intronic chr16:27447273(+) A-I      intronic chr16:27447299(+) A-I      intronic chr16:27449150(+) A-I      intronic chr16:27449939(+) A-I      intronic chr16:27449942(+) A-I      intronic chr16:27450005(+) A-I      intronic chr16:27450013(+) A-I      intronic chr16:27450037(+) A-I      intronic chr16:27450041(+) A-I      intronic chr16:27450100(+) A-I      intronic chr16:27450123(+) A-I      intronic chr16:27450136(+) A-I      intronic chr16:27450143(+) A-I      intronic chr16:27450191(+) A-I      intronic chr16:27451779(+) A-I      intronic chr16:27451846(+) A-I      intronic chr16:27451874(+) A-I      intronic chr16:27452164(+) A-I      intronic chr16:27452171(+) A-I      intronic chr16:27452211(+) A-I      intronic chr16:27453190(+) A-I      intronic chr16:27453228(+) A-I      intronic chr16:27453683(+) A-I      intronic chr16:27453687(+) A-I      intronic chr16:27453826(+) A-I      intronic chr16:27453850(+) A-I      intronic chr16:27453851(+) A-I      intronic chr16:27453859(+) A-I      intronic chr16:27453869(+) A-I      intronic chr16:27459691(+) A-I      intronic chr16:27459661(+) A-I      intronic chr16:27459672(+) A-I      intronic chr16:27451856(+) A-I      intronic chr16:27440928(+) A-I      intronic chr16:27453748(+) A-I      intronic chr16:27459678(+) A-I      intronic chr16:27440361(+) A-I      intronic chr16:27440338(+) A-I      intronic chr16:27440289(+) A-I      intronic chr16:27438877(+) A-I      intronic chr16:27438784(+) A-I      intronic chr16:27430934(+) A-I      intronic chr16:27430932(+) A-I      intronic chr16:27430894(+) A-I      intronic chr16:27430510(+) A-I      intronic chr16:27430451(+) A-I      intronic chr16:27430386(+) A-I      intronic chr16:27430366(+) A-I      intronic chr16:27430360(+) A-I      intronic chr16:27430511(+) A-I      intronic chr16:27430359(+) A-I      intronic chr16:27429952(+) A-I      intronic chr16:27429759(+) A-I      intronic chr16:27429650(+) A-I      intronic chr16:27429520(+) A-I      intronic chr16:27427674(+) A-I      intronic chr16:27440846(+) A-I      intronic chr16:27440852(+) A-I      intronic chr16:27440892(+) A-I      intronic chr16:27440945(+) A-I      intronic chr16:27427597(+) A-I      intronic chr16:27423059(+) A-I      intronic chr16:27423019(+) A-I      intronic chr16:27441015(+) A-I      intronic chr16:27422914(+) A-I      intronic chr16:27422901(+) A-I      intronic chr16:27422887(+) A-I      intronic chr16:27422858(+) A-I      intronic chr16:27422848(+) A-I      intronic chr16:27422803(+) A-I      intronic chr16:27421595(+) A-I      intronic chr16:27421515(+) A-I      intronic chr16:27421501(+) A-I      intronic chr16:27421497(+) A-I      intronic chr16:27440424(+) A-I      intronic chr16:27441080(+) A-I      intronic chr16:27461961(+) A-I      3'UTR chr16:27461970(+) A-I      3'UTR chr16:27462022(+) A-I      3'UTR chr16:27462033(+) A-I      3'UTR chr16:27462965(+) A-I      3'UTR chr16:27462941(+) A-I      3'UTR chr16:27462834(+) A-I      3'UTR chr16:27462890(+) A-I      3'UTR chr16:27447049(+) A-I      intronic chr16:27427623(+) A-I      intronic chr16:27441047(+) A-I      intronic chr16:27446555(+) A-I      intronic chr16:27430425(+) A-I      intronic chr16:27448139(+) A-I      intronic chr16:27449951(+) A-I      intronic chr16:27449974(+) A-I      intronic chr16:27430416(+) A-I      intronic chr16:27450003(+) A-I      intronic chr16:27446904(+) A-I      intronic chr16:27421458(+) A-I      intronic chr16:27448169(+) A-I      intronic chr16:27421506(+) A-I      intronic chr16:27422888(+) A-I      intronic chr16:27453824(+) A-I      intronic chr16:27421546(+) A-I      intronic chr16:27430440(+) A-I      intronic chr16:27438817(+) A-I      intronic chr16:27451674(+) A-I      intronic chr16:27452165(+) A-I      intronic chr16:27453814(+) A-I      intronic chr16:27450024(+) A-I      intronic chr16:27422925(+) A-I      intronic chr16:27440843(+) A-I      intronic chr16:27450112(+) A-I      intronic chr16:27448234(+) A-I      intronic chr16:27450080(+) A-I      intronic chr16:27453882(+) A-I      intronic chr16:27427587(+) A-I      intronic chr16:27448348(+) A-I      intronic chr16:27438748(+) A-I      intronic chr16:27448340(+) A-I      intronic chr16:27459755(+) A-I      intronic chr16:27453201(+) A-I      intronic chr16:27453211(+) A-I      intronic chr16:27449993(+) A-I      intronic chr16:27449083(+) A-I      intronic chr16:27451833(+) A-I      intronic chr16:27421423(+) A-I      intronic chr16:27453865(+) A-I      intronic chr16:27446496(+) A-I      intronic chr16:27449164(+) A-I      intronic chr16:27438916(+) A-I      intronic chr16:27430394(+) A-I      intronic chr16:27450141(+) A-I      intronic chr16:27429589(+) A-I      intronic chr16:27430438(+) A-I      intronic chr16:27431001(+) A-I      intronic chr16:27452157(+) A-I      intronic chr16:27431391(+) A-I      intronic chr16:27422877(+) A-I      intronic chr16:27453740(+) A-I      intronic chr16:27446459(+) A-I      intronic chr16:27438773(+) A-I      intronic chr16:27446385(+) A-I      intronic chr16:27453963(+) A-I      intronic chr16:27462981(+) A-I      3'UTR chr16:27431241(+) A-I      intronic chr16:27449122(+) A-I      intronic chr16:27443237(+) A-I      intronic chr16:27427558(+) A-I      intronic chr16:27452210(+) A-I      intronic chr16:27430509(+) A-I      intronic chr16:27430377(+) A-I      intronic chr16:27449817(+) A-I      intronic chr16:27444680(+) A-I      intronic chr16:27449123(+) A-I      intronic chr16:27449934(+) A-I      intronic chr16:27430397(+) A-I      intronic chr16:27448240(+) A-I      intronic chr16:27440907(+) A-I      intronic chr16:27427538(+) A-I      intronic chr16:27450040(+) A-I      intronic chr16:27421402(+) A-I      intronic chr16:27440944(+) A-I      intronic chr16:27440984(+) A-I      intronic chr16:27447259(+) A-I      intronic chr16:27446932(+) A-I      intronic chr16:27452245(+) A-I      intronic chr16:27451841(+) A-I      intronic chr16:27454875(+) A-I      intronic chr16:27440368(+) A-I      intronic chr16:27440495(+) A-I      intronic chr16:27441912(+) A-I      intronic chr16:27421504(+) A-I      intronic chr16:27453278(+) A-I      intronic chr16:27430378(+) A-I      intronic chr16:27430376(+) A-I      intronic chr16:27430349(+) A-I      intronic chr16:27440931(+) A-I      intronic chr16:27430323(+) A-I      intronic chr16:27451664(+) A-I      intronic chr16:27450002(+) A-I      intronic chr16:27430352(+) A-I      intronic chr16:27449253(+) A-I      intronic chr16:27451828(+) A-I      intronic chr16:27447283(+) A-I      intronic chr16:27447027(+) A-I      intronic chr16:27443052(+) A-I      intronic chr16:27427642(+) A-I      intronic chr16:27438781(+) A-I      intronic chr16:27453957(+) A-I      intronic chr16:27449113(+) A-I      intronic chr16:27449797(+) A-I      intronic chr16:27449096(+) A-I      intronic chr16:27430280(+) A-I      intronic chr16:27429721(+) A-I      intronic chr16:27430432(+) A-I      intronic chr16:27430326(+) A-I      intronic chr16:27416447(+) A-I      intronic chr16:27427557(+) A-I      intronic chr16:27422883(+) A-I      intronic chr16:27449149(+) A-I      intronic chr16:27446980(+) A-I      intronic chr16:27450175(+) A-I      intronic chr16:27452216(+) A-I      intronic chr16:27429597(+) A-I      intronic chr16:27416625(+) A-I      intronic chr16:27421505(+) A-I      intronic chr16:27449979(+) A-I      intronic chr16:27429713(+) A-I      intronic chr16:27430393(+) A-I      intronic chr16:27430946(+) A-I      intronic chr16:27452249(+) A-I      intronic chr16:27450146(+) A-I      intronic chr16:27431348(+) A-I      intronic chr16:27429819(+) A-I      intronic chr16:27438735(+) A-I      intronic chr16:27449141(+) A-I      intronic chr16:27446563(+) A-I      intronic chr16:27446397(+) A-I      intronic chr16:27423048(+) A-I      intronic chr16:27449199(+) A-I      intronic chr16:27453890(+) A-I      intronic chr16:27429663(+) A-I      intronic chr16:27451742(+) A-I      intronic chr16:27449145(+) A-I      intronic chr16:27422968(+) A-I      intronic chr16:27450087(+) A-I      intronic chr16:27453959(+) A-I      intronic chr16:27449125(+) A-I      intronic chr16:27428648(+) A-I      intronic chr16:27444690(+) A-I      intronic chr16:27454850(+) A-I      intronic chr16:27452207(+) A-I      intronic chr16:27444666(+) A-I      intronic chr16:27449052(+) A-I      intronic chr16:27430375(+) A-I      intronic chr16:27448236(+) A-I      intronic chr16:27450140(+) A-I      intronic chr16:27421385(+) A-I      intronic chr16:27429873(+) A-I      intronic chr16:27453802(+) A-I      intronic chr16:27446398(+) A-I      intronic chr16:27442056(+) A-I      intronic chr16:27453868(+) A-I      intronic chr16:27440909(+) A-I      intronic chr16:27421495(+) A-I      intronic chr16:27440911(+) A-I      intronic chr16:27454918(+) A-I      intronic chr16:27452152(+) A-I      intronic chr16:27441020(+) A-I      intronic chr16:27450030(+) A-I      intronic chr16:27453235(+) A-I      intronic chr16:27427659(+) A-I      intronic chr16:27429876(+) A-I      intronic chr16:27454985(+) A-I      intronic chr16:27447207(+) A-I      intronic chr16:27421536(+) A-I      intronic chr16:27430891(+) A-I      intronic chr16:27440273(+) A-I      intronic chr16:27443072(+) A-I      intronic chr16:27448238(+) A-I      intronic chr16:27449960(+) A-I      intronic chr16:27440354(+) A-I      intronic chr16:27453290(+) A-I      intronic chr16:27430330(+) A-I      intronic chr16:27451759(+) A-I      intronic chr16:27451832(+) A-I      intronic chr16:27451777(+) A-I      intronic chr16:27440864(+) A-I      intronic chr16:27451734(+) A-I      intronic chr16:27430281(+) A-I      intronic chr16:27451736(+) A-I      intronic chr16:27452225(+) A-I      intronic chr16:27430415(+) A-I      intronic chr16:27421579(+) A-I      intronic chr16:27451829(+) A-I      intronic chr16:27447151(+) A-I      intronic chr16:27430350(+) A-I      intronic chr16:27452170(+) A-I      intronic chr16:27421401(+) A-I      intronic chr16:27421407(+) A-I      intronic chr16:27451766(+) A-I      intronic chr16:27427615(+) A-I      intronic chr16:27440402(+) A-I      intronic chr16:27431338(+) A-I      intronic chr16:27450071(+) A-I      intronic chr16:27438846(+) A-I      intronic chr16:27450070(+) A-I      intronic chr16:27427599(+) A-I      intronic chr16:27453110(+) A-I      intronic chr16:27450133(+) A-I      intronic chr16:27430289(+) A-I      intronic chr16:27422884(+) A-I      intronic chr16:27429829(+) A-I      intronic chr16:27438775(+) A-I      intronic chr16:27440948(+) A-I      intronic chr16:27440914(+) A-I      intronic chr16:27451803(+) A-I      intronic chr16:27450097(+) A-I      intronic chr16:27446460(+) A-I      intronic chr16:27430372(+) A-I      intronic chr16:27454939(+) A-I      intronic chr16:27450018(+) A-I      intronic chr16:27429596(+) A-I      intronic chr16:27455006(+) A-I      intronic chr16:27422950(+) A-I      intronic chr16:27421507(+) A-I      intronic chr16:27431397(+) A-I      intronic chr16:27446486(+) A-I      intronic chr16:27446400(+) A-I      intronic chr16:27462051(+) A-I      3'UTR chr16:27462917(+) A-I      3'UTR chr16:27462995(+) A-I      3'UTR chr16:27462056(+) A-I      3'UTR chr16:27461985(+) A-I      3'UTR chr16:27462043(+) A-I      3'UTR chr16:27462893(+) A-I      3'UTR chr16:27462820(+) A-I      3'UTR chr16:27462045(+) A-I      3'UTR chr16:27462919(+) A-I      3'UTR chr16:27462758(+) A-I      3'UTR chr16:27461957(+) A-I      3'UTR chr16:27461986(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	IL21R	chr16:27430416(+) A-I intron -    22327324 chr16:27438740(+) A-I intron -    22327324 chr16:27450071(+) A-I intron -    22327324 chr16:27451833(+) A-I intron -    22327324 chr16:27461986(+) A-I intron -    22327324 chr16:27462051(+) A-I intron -    22327324 chr16:27427558(+) A-G intron -    22484847 chr16:27429829(+) A-G intron -    22484847 chr16:27429873(+) A-G intron -    22484847 chr16:27430349(+) A-G intron -    22484847 chr16:27430416(+) A-G intron -    22484847 chr16:27438775(+) A-G intron -    22484847 chr16:27440911(+) A-G intron -    22484847 chr16:27441020(+) A-G intron -    22484847 chr16:27441047(+) A-G intron -    22484847 chr16:27442056(+) A-G intron -    22484847 chr16:27444666(+) A-G intron -    22484847 chr16:27446496(+) A-G intron -    22484847 chr16:27447151(+) A-G intron -    22484847 chr16:27449145(+) A-G intron -    22484847 chr16:27449797(+) A-G intron -    22484847 chr16:27449951(+) A-G intron -    22484847 chr16:27449979(+) A-G intron -    22484847 chr16:27450003(+) A-G intron -    22484847 chr16:27450024(+) A-G intron -    22484847 chr16:27450070(+) A-G intron -    22484847 chr16:27450071(+) A-G intron -    22484847 chr16:27451742(+) A-G intron -    22484847 chr16:27451829(+) A-G intron -    22484847 chr16:27451832(+) A-G intron -    22484847 chr16:27451833(+) A-G intron -    22484847 chr16:27452157(+) A-G intron -    22484847 chr16:27452170(+) A-G intron -    22484847 chr16:27452249(+) A-G intron -    22484847 chr16:27453110(+) A-G intron -    22484847 chr16:27453814(+) A-G intron -    22484847 chr16:27453890(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	IL21R	chr16:27413832-27413833(+) m6A 5'UTR       - chr16:27413858-27413859(+) m6A 5'UTR       - chr16:27413888-27413889(+) m6A 5'UTR       - chr16:27413932-27413933(+) m6A 5'UTR       - chr16:27445739-27445740(+) m6A CDS       - chr16:27448813-27448814(+) m6A CDS       - chr16:27448954-27448955(+) m6A CDS       - chr16:27456515-27456516(+) m6A CDS//exon       - chr16:27456580-27456581(+) m6A CDS//exon       - chr16:27457401-27457402(+) m6A CDS//exon       - chr16:27459898-27459899(+) m6A CDS//exon       - chr16:27459994-27459995(+) m6A CDS//exon       26404942 chr16:27460056-27460057(+) m6A CDS       25456834//26404942 chr16:27460194-27460195(+) m6A CDS       24209618//25456834//26404942 chr16:27460233-27460234(+) m6A CDS       25456834//26404942 chr16:27460253-27460254(+) m6A CDS       25456834//26404942 chr16:27460326-27460327(+) m6A CDS       25456834//26404942 chr16:27460359-27460360(+) m6A CDS       25456834//26404942 chr16:27460372-27460373(+) m6A CDS       25456834//26404942 chr16:27460449-27460450(+) m6A CDS       25456834//26404942 chr16:27460528-27460529(+) m6A CDS       25456834//26404942 chr16:27460588-27460589(+) m6A CDS       25456834 chr16:27460657-27460658(+) m6A 3'UTR       - chr16:27460906-27460907(+) m6A 3'UTR       - chr16:27461295-27461296(+) m6A 3'UTR       25456834 chr16:27461368-27461369(+) m6A 3'UTR       - chr16:27461430-27461431(+) m6A 3'UTR       - chr16:27461627-27461628(+) m6A 3'UTR       26404942 chr16:27461660-27461661(+) m6A 3'UTR       26404942

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-365a-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	IL21R	Exosome Blood     - Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-365a-5p
Interactor2: IL21R

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).