Basic Information:

  VIRBase ID:  

HHID00014656

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365a-5p:  MIMAT0009199          DNAJC15:  NM_013238     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-365a-5p	DNAJC15
miRBase Accession/Entrez ID	MIMAT0009199	29103
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	DNAJD1//HSD18//MCJ

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-365a-5p	rs1166908611 chr16:14309308    T/C rs1368596991 chr16:14309314    G/A rs1380926089 chr16:14309318    A/G rs1396179427 chr16:14309310    G/C rs1428928383 chr16:14309320    G/A rs773834113 chr16:14309301    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	DNAJC15	chr13:43672005(+) A-I      intronic chr13:43671993(+) A-I      intronic chr13:43671994(+) A-I      intronic chr13:43672022(+) A-I      intronic chr13:43674389(+) A-I      intronic chr13:43659417(+) A-I      intronic chr13:43659382(+) A-I      intronic chr13:43659222(+) A-I      intronic chr13:43607979(+) A-I      intronic chr13:43657542(+) A-I      intronic chr13:43657510(+) A-I      intronic chr13:43657445(+) A-I      intronic chr13:43657403(+) A-I      intronic chr13:43655750(+) A-I      intronic chr13:43626672(+) A-I      intronic chr13:43625240(+) A-I      intronic chr13:43625228(+) A-I      intronic chr13:43625191(+) A-I      intronic chr13:43612849(+) A-I      intronic chr13:43612845(+) A-I      intronic chr13:43612775(+) A-I      intronic chr13:43612765(+) A-I      intronic chr13:43612745(+) A-I      intronic chr13:43608556(+) A-I      intronic chr13:43667616(+) A-I      intronic chr13:43606800(+) A-I      intronic chr13:43602014(+) A-I      intronic chr13:43601959(+) A-I      intronic chr13:43601886(+) A-I      intronic chr13:43601849(+) A-I      intronic chr13:43599919(+) A-I      intronic chr13:43599112(+) A-I      intronic chr13:43599034(+) A-I      intronic chr13:43598687(+) A-I      intronic chr13:43598937(+) A-I      intronic chr13:43659350(+) A-I      intronic chr13:43608119(+) A-I      intronic chr13:43672062(+) A-I      intronic chr13:43659452(+) A-I      intronic chr13:43667798(+) A-I      intronic chr13:43601998(+) A-I      intronic chr13:43659280(+) A-I      intronic chr13:43612912(+) A-I      intronic chr13:43599076(+) A-I      intronic chr13:43606907(+) A-I      intronic chr13:43599135(+) A-I      intronic chr13:43625180(+) A-I      intronic chr13:43607893(+) A-I      intronic chr13:43598950(+) A-I      intronic chr13:43598936(+) A-I      intronic chr13:43599011(+) A-I      intronic chr13:43659238(+) A-I      intronic chr13:43659341(+) A-I      intronic chr13:43625319(+) A-I      intronic chr13:43600969(+) A-I      intronic chr13:43598954(+) A-I      intronic chr13:43607910(+) A-I      intronic chr13:43666999(+) A-I      intronic chr13:43599050(+) A-I      intronic chr13:43659205(+) A-I      intronic chr13:43659409(+) A-I      intronic chr13:43659266(+) A-I      intronic chr13:43622608(+) A-I      intronic chr13:43599122(+) A-I      intronic chr13:43659312(+) A-I      intronic chr13:43608581(+) A-I      intronic chr13:43666946(+) A-I      intronic chr13:43625210(+) A-I      intronic chr13:43599007(+) A-I      intronic chr13:43657443(+) A-I      intronic chr13:43602013(+) A-I      intronic chr13:43608006(+) A-I      intronic chr13:43633630(+) A-I      intronic chr13:43659245(+) A-I      intronic chr13:43601954(+) A-I      intronic chr13:43659337(+) A-I      intronic chr13:43659244(+) A-I      intronic chr13:43667685(+) A-I      intronic chr13:43667595(+) A-I      intronic chr13:43643403(+) A-I      intronic chr13:43666895(+) A-I      intronic chr13:43608617(+) A-I      intronic chr13:43643420(+) A-I      intronic chr13:43666947(+) A-I      intronic chr13:43659267(+) A-I      intronic chr13:43659344(+) A-I      intronic chr13:43601982(+) A-I      intronic chr13:43655714(+) A-I      intronic chr13:43659377(+) A-I      intronic chr13:43655850(+) A-I      intronic chr13:43666969(+) A-I      intronic chr13:43612807(+) A-I      intronic chr13:43643940(+) A-I      intronic chr13:43666939(+) A-I      intronic chr13:43607940(+) A-I      intronic chr13:43655655(+) A-I      intronic chr13:43643951(+) A-I      intronic chr13:43659338(+) A-I      intronic chr13:43625211(+) A-I      intronic chr13:43608658(+) A-I      intronic chr13:43625204(+) A-I      intronic chr13:43667025(+) A-I      intronic chr13:43664867(+) A-I      intronic chr13:43601932(+) A-I      intronic chr13:43625175(+) A-I      intronic chr13:43606840(+) A-I      intronic chr13:43659468(+) A-I      intronic chr13:43659376(+) A-I      intronic chr13:43655628(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	DNAJC15	chr13:43643940(+) A-G intron -    22484847 chr13:43643951(+) A-G intron -    22484847 chr13:43659205(+) A-G intron -    22484847 chr13:43657443(+) A-G intron -    22484847 chr13:43659238(+) A-G intron -    22484847 chr13:43659245(+) A-G intron -    22484847 chr13:43659267(+) A-G intron -    22484847 chr13:43659376(+) A-G intron -    22484847 chr13:43659377(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	DNAJC15	chr13:43597685-43597686(+) m6A 5'UTR//exon       - chr13:43643115-43643116(+) m6A CDS//exon       27773535 chr13:43652779-43652780(+) m6A CDS//exon       27773535 chr13:43653002-43653003(+) m6A exon//intron       27773535 chr13:43653007-43653008(+) m6A exon//intron       27773535 chr13:43659931-43659932(+) m6A CDS       27773535 chr13:43681355-43681356(+) m6A CDS       24981863//27773535 chr13:43681366-43681367(+) m6A CDS       24981863//27773535 chr13:43681377-43681378(+) m6A CDS       24981863//27773535 chr13:43681393-43681394(+) m6A 3'UTR       24981863//27773535 chr13:43681421-43681422(+) m6A 3'UTR       24284625//24981863//27773535 chr13:43681459-43681460(+) m6A 3'UTR       24284625//24981863//27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-365a-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	DNAJC15	Exosome Blood     - Nucleus HCC cell line (HepG2)     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-365a-5p
Interactor2: DNAJC15

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).