Basic Information:

  VIRBase ID:  

HHID00014532

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365a-5p:  MIMAT0009199          LILRB3:  NR_135495     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-365a-5p	LILRB3
miRBase Accession/Entrez ID	MIMAT0009199	11025
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CD85A//HL9//ILT-5//ILT5//LILRA6//LIR-3//LIR3//PIR-B//PIRB

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-365a-5p	rs1166908611 chr16:14309308    T/C rs1368596991 chr16:14309314    G/A rs1380926089 chr16:14309318    A/G rs1396179427 chr16:14309310    G/C rs1428928383 chr16:14309320    G/A rs773834113 chr16:14309301    G/C

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	LILRB3	chr19:54720719-54720720(-) m6A 3'UTR       27371828 chr19:54720726-54720727(-) m6A 3'UTR       27371828 chr19:54720760-54720761(-) m6A 3'UTR       27371828 chr19:54720815-54720816(-) m6A 3'UTR       27371828 chr19:54720824-54720825(-) m6A 3'UTR       27371828 chr19:54720844-54720845(-) m6A 3'UTR       27371828 chr19:54720857-54720858(-) m6A 3'UTR       27371828 chr19:54720873-54720874(-) m6A 3'UTR       27371828 chr19:54720883-54720884(-) m6A 3'UTR       27371828 chr19:54720915-54720916(-) m6A 3'UTR       27371828 chr19:54720922-54720923(-) m6A 3'UTR       27371828 chr19:54720944-54720945(-) m6A 3'UTR       27371828 chr19:54721006-54721007(-) m6A 3'UTR//CDS//exon       27371828 chr19:54721194-54721195(-) m6A 3'UTR//CDS//exon       27371828 chr19:54721206-54721207(-) m6A 3'UTR//CDS//exon       27371828 chr19:54721224-54721225(-) m6A 3'UTR//CDS//exon       27371828 chr19:54721233-54721234(-) m6A 3'UTR//CDS//exon       27371828 chr19:54721295-54721296(-) m6A 3'UTR//CDS//exon       27371828 chr19:54721326-54721327(-) m6A 3'UTR//CDS//exon       27371828 chr19:54721372-54721373(-) m6A exon//intron       27371828 chr19:54721380-54721381(-) m6A exon//intron       27371828 chr19:54721415-54721416(-) m6A exon//intron       27371828 chr19:54722236-54722237(-) m6A 3'UTR//CDS//exon       27371828 chr19:54722251-54722252(-) m6A 3'UTR//CDS//exon       27371828 chr19:54722266-54722267(-) m6A 3'UTR//CDS//exon       27371828 chr19:54722473-54722474(-) m6A exon//intron       27371828 chr19:54722494-54722495(-) m6A exon//intron       27371828 chr19:54722518-54722519(-) m6A 3'UTR//CDS//exon       27371828 chr19:54722649-54722650(-) m6A 3'UTR//CDS//exon       27371828 chr19:54722662-54722663(-) m6A 3'UTR//CDS//exon       27371828 chr19:54722695-54722696(-) m6A 3'UTR//CDS//exon       - chr19:54722706-54722707(-) m6A 3'UTR//CDS//exon       - chr19:54722727-54722728(-) m6A exon//intron       - chr19:54723003-54723004(-) m6A 3'UTR//CDS//exon       - chr19:54723010-54723011(-) m6A 3'UTR//CDS//exon       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-365a-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	LILRB3	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-365a-5p
Interactor2: LILRB3

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).