Basic Information:

  VIRBase ID:  

HHID00014441

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365a-5p:  MIMAT0009199          PLCH2:  NM_001303013     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-365a-5p	PLCH2
miRBase Accession/Entrez ID	MIMAT0009199	9651
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	PLC-eta2//PLC-L4//PLCeta2//PLCL4

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-365a-5p	rs1166908611 chr16:14309308    T/C rs1368596991 chr16:14309314    G/A rs1380926089 chr16:14309318    A/G rs1396179427 chr16:14309310    G/C rs1428928383 chr16:14309320    G/A rs773834113 chr16:14309301    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PLCH2	chr1:2436080(+) A-I      NonSyn:Arg->Gly

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PLCH2	chr1:2434559-2434560(+) m6A exon//intron       27773536 chr1:2435508-2435509(+) m6A 3'UTR//CDS//exon       24981863 chr1:2435540-2435541(+) m6A 3'UTR//CDS//exon       24981863 chr1:2435558-2435559(+) m6A 3'UTR//CDS//exon       24981863 chr1:2435650-2435651(+) m6A 3'UTR//CDS//exon       24981863 chr1:2435822-2435823(+) m6A 3'UTR//CDS//exon       - chr1:2435912-2435913(+) m6A 3'UTR//CDS//exon       - chr1:2435978-2435979(+) m6A 3'UTR//CDS//exon       24981863 chr1:2436054-2436055(+) m6A 3'UTR//CDS//exon       24981863//22575960 chr1:2436140-2436141(+) m6A 3'UTR//CDS//exon       24981863 chr1:2436225-2436226(+) m6A 3'UTR//CDS//exon       25456834//24981863 chr1:2436256-2436257(+) m6A 3'UTR//CDS//exon       25456834//24981863 chr1:2436290-2436291(+) m6A 3'UTR//CDS//exon       25456834//24981863 chr1:2436341-2436342(+) m6A 3'UTR//CDS//exon       - chr1:2436486-2436487(+) m6A 3'UTR//CDS//exon       24981863//22575960 chr1:2436510-2436511(+) m6A 3'UTR//CDS//exon       24981863//22575960 chr1:2436722-2436723(+) m6A 3'UTR//exon       27773536 chr1:2436744-2436745(+) m6A 3'UTR//exon       27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-365a-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	PLCH2	Exosome Blood     - Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-365a-5p
Interactor2: PLCH2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).