Basic Information:

  VIRBase ID:  

HHID00014438

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365a-5p:  MIMAT0009199          GOSR2:  NR_148350     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-365a-5p	GOSR2
miRBase Accession/Entrez ID	MIMAT0009199	9570
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	Bos1//EPM6//GS27

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-365a-5p	rs1166908611 chr16:14309308    T/C rs1368596991 chr16:14309314    G/A rs1380926089 chr16:14309318    A/G rs1396179427 chr16:14309310    G/C rs1428928383 chr16:14309320    G/A rs773834113 chr16:14309301    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	GOSR2	chr17:45013449(+) A-I      3'UTR chr17:45011790(+) A-I      intronic chr17:45011822(+) A-I      intronic chr17:45015375(+) A-I      intronic chr17:45015320(+) A-I      intronic chr17:45011754(+) A-I      intronic chr17:45015367(+) A-I      intronic chr17:45011242(+) A-I      intronic chr17:45011821(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	GOSR2	chr17:45000486-45000487(+) m6A 5'UTR       25456834//24981863 chr17:45000937-45000938(+) m6A 5'UTR//exon//intron       24981863 chr17:45000951-45000952(+) m6A 5'UTR//exon//intron       24981863 chr17:45006932-45006933(+) m6A CDS//exon       24284625//24981863 chr17:45006970-45006971(+) m6A exon//intron       24981863 chr17:45008494-45008495(+) m6A CDS//exon       24981863 chr17:45008570-45008571(+) m6A CDS//exon       24981863 chr17:45009666-45009667(+) m6A 3'UTR//intron       - chr17:45009681-45009682(+) m6A 3'UTR//intron       - chr17:45009701-45009702(+) m6A 3'UTR//intron       - chr17:45009722-45009723(+) m6A 3'UTR//intron       - chr17:45009727-45009728(+) m6A 3'UTR//intron       - chr17:45009733-45009734(+) m6A 3'UTR//intron       - chr17:45009755-45009756(+) m6A 3'UTR//intron       - chr17:45009761-45009762(+) m6A 3'UTR//intron       - chr17:45012507-45012508(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535 chr17:45012514-45012515(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535 chr17:45012522-45012523(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535 chr17:45012554-45012555(+) m6A CDS//intron       24284625//24981863 chr17:45012653-45012654(+) m6A 3'UTR//intron       24981863 chr17:45013934-45013935(+) m6A 3'UTR//intron       - chr17:45015967-45015968(+) m6A CDS       24284625//24209618//24981863//26404942//22608085 chr17:45016052-45016053(+) m6A CDS       24284625//24209618//24981863//22608085 chr17:45016148-45016149(+) m6A 3'UTR//intron       24284625//24209618//24981863 chr17:45017940-45017941(+) m6A CDS//intron       25456834//24981863 chr17:45017994-45017995(+) m6A 3'UTR//intron       25456834//24981863 chr17:45018033-45018034(+) m6A 3'UTR//intron       25456834//24981863//22608085 chr17:45018042-45018043(+) m6A 3'UTR//intron       25456834//24981863//22608085 chr17:45018101-45018102(+) m6A 3'UTR//intron       24981863//22608085 chr17:45041069-45041070(+) m6A CDS//intron       24981863//22608085 chr17:45043901-45043902(+) m6A CDS       24284625//24209618//24981863//22608085 chr17:45043930-45043931(+) m6A CDS       24284625//24209618//24981863//22608085 chr17:45043936-45043937(+) m6A CDS       24284625//24209618//24981863//22608085 chr17:45044029-45044030(+) m6A CDS       24284625//24209618//24981863//22608085 chr17:45044047-45044048(+) m6A CDS       24284625//24209618//24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-365a-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	GOSR2	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-365a-5p
Interactor2: GOSR2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).