Basic Information:

  VIRBase ID:  

HHID00014430

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365a-5p:  MIMAT0009199          RAB9A:  NM_001195328     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-365a-5p	RAB9A
miRBase Accession/Entrez ID	MIMAT0009199	9367
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	RAB9

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-365a-5p	rs1166908611 chr16:14309308    T/C rs1368596991 chr16:14309314    G/A rs1380926089 chr16:14309318    A/G rs1396179427 chr16:14309310    G/C rs1428928383 chr16:14309320    G/A rs773834113 chr16:14309301    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RAB9A	chrX:13718154(+) A-I      intronic chrX:13718185(+) A-I      intronic chrX:13718204(+) A-I      intronic chrX:13718193(+) A-I      intronic chrX:13718197(+) A-I      intronic chrX:13714325(+) A-I      intronic chrX:13714444(+) A-I      intronic chrX:13724550(+) A-I      intronic chrX:13726413(+) A-I      intronic chrX:13726304(+) A-I      intronic chrX:13724727(+) A-I      intronic chrX:13724604(+) A-I      intronic chrX:13709691(+) A-I      intronic chrX:13709614(+) A-I      intronic chrX:13709579(+) A-I      intronic chrX:13709734(+) A-I      intronic chrX:13709699(+) A-I      intronic chrX:13714265(+) A-I      intronic chrX:13709623(+) A-I      intronic chrX:13726296(+) A-I      intronic chrX:13726377(+) A-I      intronic chrX:13709700(+) A-I      intronic chrX:13709658(+) A-I      intronic chrX:13709572(+) A-I      intronic chrX:13709659(+) A-I      intronic chrX:13709711(+) A-I      intronic chrX:13709626(+) A-I      intronic chrX:13709569(+) A-I      intronic chrX:13709627(+) A-I      intronic chrX:13709636(+) A-I      intronic chrX:13709632(+) A-I      intronic chrX:13709731(+) A-I      intronic chrX:13709621(+) A-I      intronic chrX:13719020(+) A-I      intronic chrX:13726387(+) A-I      intronic chrX:13726277(+) A-I      intronic chrX:13726241(+) A-I      intronic chrX:13724591(+) A-I      intronic chrX:13719003(+) A-I      intronic chrX:13726177(+) A-I      intronic chrX:13726255(+) A-I      intronic chrX:13726363(+) A-I      intronic chrX:13718253(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	RAB9A	chrX:13709569(+) A-I intron -    22028664 chrX:13709572(+) A-I intron -    22028664 chrX:13709579(+) A-I intron -    22028664 chrX:13709614(+) A-I intron -    22028664 chrX:13709619(+) A-I intron -    22028664 chrX:13709621(+) A-I intron -    22028664 chrX:13709623(+) A-I intron -    22028664 chrX:13709626(+) A-I intron -    22028664 chrX:13709627(+) A-I intron -    22028664 chrX:13709632(+) A-I intron -    22028664 chrX:13709636(+) A-I intron -    22028664 chrX:13709658(+) A-I intron -    22028664 chrX:13709659(+) A-I intron -    22028664 chrX:13709691(+) A-I intron -    22028664 chrX:13709699(+) A-I intron -    22028664 chrX:13709700(+) A-I intron -    22028664 chrX:13709711(+) A-I intron -    22028664 chrX:13709731(+) A-I intron -    22028664 chrX:13709734(+) A-I intron -    22028664 chrX:13726241(+) A-G intron -    22484847 chrX:13726296(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RAB9A	chrX:13721973-13721974(+) m6A 5'UTR//intron       24284625 chrX:13726938-13726939(+) m6A CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chrX:13727023-13727024(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chrX:13727049-13727050(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chrX:13727084-13727085(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chrX:13727154-13727155(+) m6A CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chrX:13727295-13727296(+) m6A CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chrX:13727321-13727322(+) m6A CDS//exon       24284625//24981863//27773535//22575960//22608085 chrX:13727417-13727418(+) m6A CDS//exon       24284625//24981863//26404942//27773535//22608085 chrX:13727583-13727584(+) m6A 3'UTR       24284625//24981863//27773535//22608085 chrX:13727620-13727621(+) m6A 3'UTR       24284625//24981863//27773535//22608085 chrX:13727751-13727752(+) m6A 3'UTR       24981863//27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-365a-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	RAB9A	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-365a-5p
Interactor2: RAB9A

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).