Basic Information:

  VIRBase ID:  

HHID00014417

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365a-5p:  MIMAT0009199          SEC22C:  NM_032970     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-365a-5p	SEC22C
miRBase Accession/Entrez ID	MIMAT0009199	9117
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	SEC22L3

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-365a-5p	rs1166908611 chr16:14309308    T/C rs1368596991 chr16:14309314    G/A rs1380926089 chr16:14309318    A/G rs1396179427 chr16:14309310    G/C rs1428928383 chr16:14309320    G/A rs773834113 chr16:14309301    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SEC22C	chr3:42607910(-) A-I      intronic chr3:42608547(-) A-I      intronic chr3:42608049(-) A-I      intronic chr3:42607925(-) A-I      intronic chr3:42596656(-) A-I      intronic chr3:42596885(-) A-I      intronic chr3:42596914(-) A-I      intronic chr3:42596933(-) A-I      intronic chr3:42608581(-) A-I      intronic chr3:42614949(-) A-I      intronic chr3:42614934(-) A-I      intronic chr3:42614917(-) A-I      intronic chr3:42606428(-) A-I      intronic chr3:42608004(-) A-I      intronic chr3:42596946(-) A-I      intronic chr3:42608343(-) A-I      intronic chr3:42608604(-) A-I      intronic chr3:42608606(-) A-I      intronic chr3:42608667(-) A-I      intronic chr3:42606449(-) A-I      intronic chr3:42596881(-) A-I      intronic chr3:42609890(-) A-I      intronic chr3:42608330(-) A-I      intronic chr3:42617410(-) A-I      intronic chr3:42596870(-) A-I      intronic chr3:42608461(-) A-I      intronic chr3:42606347(-) A-I      intronic chr3:42596954(-) A-I      intronic chr3:42608324(-) A-I      intronic chr3:42607912(-) A-I      intronic chr3:42608599(-) A-I      intronic chr3:42608071(-) A-I      intronic chr3:42610075(-) A-I      intronic chr3:42600099(-) A-I      intronic chr3:42602405(-) A-I      intronic chr3:42608621(-) A-I      intronic chr3:42592564(-) A-I      intronic chr3:42596878(-) A-I      intronic chr3:42600116(-) A-I      intronic chr3:42596973(-) A-I      intronic chr3:42608541(-) A-I      intronic chr3:42601996(-) A-I      intronic chr3:42607979(-) A-I      intronic chr3:42608636(-) A-I      intronic chr3:42608683(-) A-I      intronic chr3:42616462(-) A-I      intronic chr3:42596894(-) A-I      intronic chr3:42608562(-) A-I      intronic chr3:42596690(-) A-I      intronic chr3:42608591(-) A-I      intronic chr3:42596977(-) A-I      intronic chr3:42596648(-) A-I      intronic chr3:42596015(-) A-I      intronic chr3:42596001(-) A-I      intronic chr3:42606388(-) A-I      intronic chr3:42606290(-) A-I      intronic chr3:42596727(-) A-I      intronic chr3:42601997(-) A-I      intronic chr3:42608598(-) A-I      intronic chr3:42602404(-) A-I      intronic chr3:42601906(-) A-I      intronic chr3:42616604(-) A-I      intronic chr3:42608563(-) A-I      intronic chr3:42609878(-) A-I      intronic chr3:42608661(-) A-I      intronic chr3:42608534(-) A-I      intronic chr3:42614563(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SEC22C	chr3:42595856(-) T-C intron -    22484847 chr3:42596648(-) A-G intron -    22484847 chr3:42596881(-) A-G intron -    22484847 chr3:42596973(-) A-G intron -    22484847 chr3:42596977(-) A-G intron -    22484847 chr3:42602405(-) A-G intron -    22484847 chr3:42606431(-) A-G intron -    22484847 chr3:42608071(-) A-G intron -    22484847 chr3:42608251(-) A-G intron -    22484847 chr3:42608323(-) A-G intron -    22484847 chr3:42608324(-) A-G intron -    22484847 chr3:42608554(-) A-G intron -    22484847 chr3:42608591(-) A-G intron -    22484847 chr3:42608599(-) A-G intron -    22484847 chr3:42608622(-) A-G intron -    22484847 chr3:42608666(-) A-G intron -    22484847 chr3:42609878(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SEC22C	chr3:42591990-42591991(-) m6A 3'UTR//intron       24981863//22608085 chr3:42592048-42592049(-) m6A 3'UTR//intron       22608085 chr3:42592072-42592073(-) m6A 3'UTR//intron       27773535//22608085 chr3:42592099-42592100(-) m6A 3'UTR//intron       27773535 chr3:42592648-42592649(-) m6A 3'UTR//intron       27773535 chr3:42592719-42592720(-) m6A 3'UTR//intron       24981863//27773535 chr3:42592802-42592803(-) m6A 3'UTR//intron       27773535 chr3:42592808-42592809(-) m6A 3'UTR//intron       27773535 chr3:42594065-42594066(-) m6A 3'UTR//intron       24981863//22608085 chr3:42594135-42594136(-) m6A 3'UTR//intron       24981863//27773535//22608085 chr3:42594157-42594158(-) m6A 3'UTR//intron       24981863//27773535//22608085 chr3:42594409-42594410(-) m6A 3'UTR//intron       27773535 chr3:42594498-42594499(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22608085 chr3:42594598-42594599(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr3:42594619-42594620(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr3:42594627-42594628(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr3:42594839-42594840(-) m6A CDS//intron       24284625//24981863//22608085 chr3:42594906-42594907(-) m6A CDS//intron       - chr3:42623475-42623476(-) m6A 5'UTR//exon//intron       24981863 chr3:42623692-42623693(-) m6A 5'UTR//intron       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-365a-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	SEC22C	Chromatin K562 cells     - Cytosol K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-365a-5p
Interactor2: SEC22C

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).