Detail Information

Basic Information:


  VIRBase ID:  

HHID00014398

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365a-5p:           TNFRSF10A:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-365a-5p TNFRSF10A
miRBase
Accession/Entrez ID		 MIMAT0009199 8797
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - APO2//CD261//DR4//TRAILR-1//TRAILR1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-365a-5p
rs1166908611 chr16:14309308    T/C
rs1368596991 chr16:14309314    G/A
rs1380926089 chr16:14309318    A/G
rs1396179427 chr16:14309310    G/C
rs1428928383 chr16:14309320    G/A
rs773834113 chr16:14309301    G/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TNFRSF10A
chr8:23078808(-) A-I      intronic
chr8:23053845(-) A-I      intronic
chr8:23053737(-) A-I      intronic
chr8:23071132(-) A-I      intronic
chr8:23052563(-) A-I      intronic
chr8:23052509(-) A-I      intronic
chr8:23052658(-) A-I      intronic
chr8:23052469(-) A-I      intronic
chr8:23078764(-) A-I      intronic
chr8:23078032(-) A-I      intronic
chr8:23052585(-) A-I      intronic
chr8:23078721(-) A-I      intronic
chr8:23052489(-) A-I      intronic
chr8:23078030(-) A-I      intronic
chr8:23078026(-) A-I      intronic
chr8:23077864(-) A-I      intronic
chr8:23058729(-) A-I      intronic
chr8:23052615(-) A-I      intronic
chr8:23071141(-) A-I      intronic
chr8:23080851(-) A-I      intronic
chr8:23071140(-) A-I      intronic
chr8:23071099(-) A-I      intronic
chr8:23061368(-) A-I      intronic
chr8:23061362(-) A-I      intronic
chr8:23061358(-) A-I      intronic
chr8:23061352(-) A-I      intronic
chr8:23078873(-) A-I      intronic
chr8:23078847(-) A-I      intronic
chr8:23078809(-) A-I      intronic
chr8:23071186(-) A-I      intronic
chr8:23071229(-) A-I      intronic
chr8:23071230(-) A-I      intronic
chr8:23071620(-) A-I      intronic
chr8:23071835(-) A-I      intronic
chr8:23071863(-) A-I      intronic
chr8:23072786(-) A-I      intronic
chr8:23072787(-) A-I      intronic
chr8:23072837(-) A-I      intronic
chr8:23073424(-) A-I      intronic
chr8:23073428(-) A-I      intronic
chr8:23073447(-) A-I      intronic
chr8:23074092(-) A-I      intronic
chr8:23080641(-) A-I      intronic
chr8:23080644(-) A-I      intronic
chr8:23081596(-) A-I      intronic
chr8:23081583(-) A-I      intronic
chr8:23080850(-) A-I      intronic
chr8:23080750(-) A-I      intronic
chr8:23048980(-) A-I      3'UTR
chr8:23049112(-) A-I      3'UTR
chr8:23049085(-) A-I      3'UTR
chr8:23048976(-) A-I      3'UTR
chr8:23048954(-) A-I      3'UTR
chr8:23049031(-) A-I      3'UTR
chr8:23048985(-) A-I      3'UTR
chr8:23048990(-) A-I      3'UTR
chr8:23049017(-) A-I      3'UTR
chr8:23048881(-) A-I      3'UTR
chr8:23048923(-) A-I      3'UTR
chr8:23048952(-) A-I      3'UTR
chr8:23049119(-) A-I      3'UTR
chr8:23049120(-) A-I      3'UTR
chr8:23048987(-) A-I      3'UTR
chr8:23048982(-) A-I      3'UTR
chr8:23048981(-) A-I      3'UTR
chr8:23048950(-) A-I      3'UTR
chr8:23049123(-) A-I      3'UTR
chr8:23049040(-) A-I      3'UTR
chr8:23072785(-) A-I      intronic
chr8:23071879(-) A-I      intronic
chr8:23071125(-) A-I      intronic
chr8:23071136(-) A-I      intronic
chr8:23071179(-) A-I      intronic
chr8:23073604(-) A-I      intronic
chr8:23048940(-) A-I      3'UTR
chr8:23048914(-) A-I      3'UTR
chr8:23048893(-) A-I      3'UTR
chr8:23074867(-) A-I      intronic
chr8:23074083(-) A-I      intronic
chr8:23073603(-) A-I      intronic
chr8:23074143(-) A-I      intronic
chr8:23080873(-) A-I      intronic
chr8:23052589(-) A-I      intronic
chr8:23081730(-) A-I      intronic
chr8:23071117(-) A-I      intronic
chr8:23071162(-) A-I      intronic
chr8:23081766(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TNFRSF10A
chr8:23074923(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TNFRSF10A
chr8:23048063-23048064(-) m6A 3'UTR       27773535
chr8:23048176-23048177(-) m6A 3'UTR       24284625//24981863//27773535
chr8:23048268-23048269(-) m6A 3'UTR       24284625//24981863//26404942//27773535//22575960
chr8:23048374-23048375(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27371828//22575960
chr8:23048428-23048429(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27371828//27773536//22575960
chr8:23048458-23048459(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27371828//27773536//22575960
chr8:23048476-23048477(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27371828//27773536//22575960
chr8:23048523-23048524(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27371828//27773536//22575960
chr8:23048546-23048547(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27371828//27773536//22575960
chr8:23048581-23048582(-) m6A 3'UTR       24284625//25456834//24981863//26404942//27773535//27371828//22575960
chr8:23048595-23048596(-) m6A 3'UTR       24284625//25456834//24981863//26404942//27773535//27371828//22575960
chr8:23048657-23048658(-) m6A 3'UTR       24284625//25456834//24981863//26404942//27773535//27371828//22575960
chr8:23048682-23048683(-) m6A 3'UTR       24284625//25456834//24981863//26404942//27773535//27371828//22575960
chr8:23048691-23048692(-) m6A 3'UTR       24284625//25456834//24981863//26404942//27773535//27371828//22575960
chr8:23048820-23048821(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27371828//22575960
chr8:23048847-23048848(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27371828//22575960
chr8:23048859-23048860(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27371828//22575960
chr8:23048907-23048908(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22575960
chr8:23049028-23049029(-) m6A 3'UTR       24284625//24981863//27773535
chr8:23049202-23049203(-) m6A 3'UTR       24284625//25456834//24981863//26404942//27773535
chr8:23049264-23049265(-) m6A CDS       24284625//25456834//24981863//26404942//27773535//27371828//22575960
chr8:23049276-23049277(-) m6A CDS       24284625//25456834//24981863//26404942//27773535//27371828//22575960
chr8:23049299-23049300(-) m6A CDS       24284625//25456834//24981863//26404942//27773535//27371828//22575960
chr8:23049358-23049359(-) m6A CDS//exon       24284625//25456834//24981863//26404942//27773535//27371828//22575960
chr8:23049450-23049451(-) m6A CDS//exon       24284625//27773535//22575960
chr8:23049471-23049472(-) m6A CDS//exon       24284625//27773535//22575960
chr8:23049495-23049496(-) m6A CDS//exon       24284625//27773535
chr8:23058105-23058106(-) m6A CDS       24284625
chr8:23059369-23059370(-) m6A 5'UTR//CDS       24284625//22575960
chr8:23059376-23059377(-) m6A 5'UTR//CDS       24284625//22575960
chr8:23059395-23059396(-) m6A 5'UTR//CDS       24284625//22575960
chr8:23082349-23082350(-) m6A CDS//intron       24284625//25456834//27773536
chr8:23082385-23082386(-) m6A CDS//intron       24284625//25456834//27371828//27773536
chr8:23082394-23082395(-) m6A CDS//intron       24284625//25456834//27371828//27773536
chr8:23082436-23082437(-) m6A CDS//intron       24981863//27371828//27773536
chr8:23082495-23082496(-) m6A CDS//intron       24284625//24981863//26404942//27773535//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-365a-5p
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
TNFRSF10A
Chromatin K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus K562 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-365a-5p
Interactor2: TNFRSF10A

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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