Basic Information:

  VIRBase ID:  

HHID00014353

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365a-5p:  MIMAT0009199          UPK2:  NM_006760     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-365a-5p	UPK2
miRBase Accession/Entrez ID	MIMAT0009199	7379
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	UP2//UPII

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-365a-5p	rs1166908611 chr16:14309308    T/C rs1368596991 chr16:14309314    G/A rs1380926089 chr16:14309318    A/G rs1396179427 chr16:14309310    G/C rs1428928383 chr16:14309320    G/A rs773834113 chr16:14309301    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	UPK2	chr11:118825763(+) A-I      intronic chr11:118825694(+) A-I      intronic chr11:118802765(+) A-I      intronic chr11:118818369(+) A-I      intronic chr11:118806472(+) A-I      intronic chr11:118816466(+) A-I      intronic chr11:118825118(+) A-I      intronic chr11:118804893(+) A-I      intronic chr11:118806646(+) A-I      intronic chr11:118805705(+) A-I      intronic chr11:118804752(+) A-I      intronic chr11:118802830(+) A-I      intronic chr11:118825792(+) A-I      intronic chr11:118803278(+) A-I      intronic chr11:118806677(+) A-I      intronic chr11:118806680(+) A-I      intronic chr11:118806835(+) A-I      intronic chr11:118808066(+) A-I      intronic chr11:118803478(+) A-I      intronic chr11:118808077(+) A-I      intronic chr11:118808091(+) A-I      intronic chr11:118813897(+) A-I      intronic chr11:118814606(+) A-I      intronic chr11:118818279(+) A-I      intronic chr11:118805884(+) A-I      intronic chr11:118803104(+) A-I      intronic chr11:118807241(+) A-I      intronic chr11:118822573(+) A-I      intronic chr11:118825682(+) A-I      intronic chr11:118821731(+) A-I      intronic chr11:118803605(+) A-I      intronic chr11:118806246(+) A-I      intronic chr11:118802704(+) A-I      intronic chr11:118825175(+) A-I      intronic chr11:118825102(+) A-I      intronic chr11:118806609(+) A-I      intronic chr11:118806328(+) A-I      intronic chr11:118818395(+) A-I      intronic chr11:118806836(+) A-I      intronic chr11:118803107(+) A-I      intronic chr11:118805677(+) A-I      intronic chr11:118823268(+) A-I      intronic chr11:118802768(+) A-I      intronic chr11:118818325(+) A-I      intronic chr11:118803481(+) A-I      intronic chr11:118805865(+) A-I      intronic chr11:118824963(+) A-I      intronic chr11:118802868(+) A-I      intronic chr11:118802706(+) A-I      intronic chr11:118802861(+) A-I      intronic chr11:118804922(+) A-I      intronic chr11:118825780(+) A-I      intronic chr11:118806848(+) A-I      intronic chr11:118805191(+) A-I      intronic chr11:118803520(+) A-I      intronic chr11:118805943(+) A-I      intronic chr11:118803232(+) A-I      intronic chr11:118806818(+) A-I      intronic chr11:118807280(+) A-I      intronic chr11:118803551(+) A-I      intronic chr11:118802728(+) A-I      intronic chr11:118802794(+) A-I      intronic chr11:118826074(+) A-I      intronic chr11:118805816(+) A-I      intronic chr11:118802747(+) A-I      intronic chr11:118803103(+) A-I      intronic chr11:118808146(+) A-I      intronic chr11:118826041(+) A-I      intronic chr11:118803157(+) A-I      intronic chr11:118822435(+) A-I      intronic chr11:118802727(+) A-I      intronic chr11:118816442(+) A-I      intronic chr11:118814813(+) A-I      intronic chr11:118806295(+) A-I      intronic chr11:118807210(+) A-I      intronic chr11:118803159(+) A-I      intronic

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-365a-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	UPK2	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-365a-5p
Interactor2: UPK2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).