Basic Information:

  VIRBase ID:  

HHID00014349

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365a-5p:  MIMAT0009199          UBE2D3:  NM_181893     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-365a-5p	UBE2D3
miRBase Accession/Entrez ID	MIMAT0009199	7323
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	E2(17)KB3//UBC4/5//UBCH5C

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-365a-5p	rs1166908611 chr16:14309308    T/C rs1368596991 chr16:14309314    G/A rs1380926089 chr16:14309318    A/G rs1396179427 chr16:14309310    G/C rs1428928383 chr16:14309320    G/A rs773834113 chr16:14309301    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	UBE2D3	chr4:103731701(-) A-I      intronic chr4:103736368(-) A-I      intronic chr4:103736293(-) A-I      intronic chr4:103755703(-) A-I      intronic chr4:103736372(-) A-I      intronic chr4:103736369(-) A-I      intronic chr4:103736297(-) A-I      intronic chr4:103736378(-) A-I      intronic chr4:103731634(-) A-I      intronic chr4:103736379(-) A-I      intronic chr4:103731704(-) A-I      intronic chr4:103731706(-) A-I      intronic chr4:103732264(-) A-I      intronic chr4:103732446(-) A-I      intronic chr4:103732659(-) A-I      intronic chr4:103732690(-) A-I      intronic chr4:103734436(-) A-I      intronic chr4:103735506(-) A-I      intronic chr4:103735518(-) A-I      intronic chr4:103735554(-) A-I      intronic chr4:103789335(-) A-I      intronic chr4:103735567(-) A-I      intronic chr4:103736277(-) A-I      intronic chr4:103736478(-) A-I      intronic chr4:103740244(-) A-I      intronic chr4:103740296(-) A-I      intronic chr4:103740313(-) A-I      intronic chr4:103740365(-) A-I      intronic chr4:103740375(-) A-I      intronic chr4:103740485(-) A-I      intronic chr4:103755670(-) A-I      intronic chr4:103755681(-) A-I      intronic chr4:103736323(-) A-I      intronic chr4:103735606(-) A-I      intronic chr4:103732617(-) A-I      intronic chr4:103732403(-) A-I      intronic chr4:103732379(-) A-I      intronic chr4:103731769(-) A-I      intronic chr4:103731753(-) A-I      intronic chr4:103731710(-) A-I      intronic chr4:103731708(-) A-I      intronic chr4:103731663(-) A-I      intronic chr4:103755714(-) A-I      intronic chr4:103759193(-) A-I      intronic chr4:103777351(-) A-I      intronic chr4:103778989(-) A-I      intronic chr4:103783159(-) A-I      intronic chr4:103784407(-) A-I      intronic chr4:103788892(-) A-I      intronic chr4:103789306(-) A-I      intronic chr4:103789327(-) A-I      intronic chr4:103789358(-) A-I      intronic chr4:103786573(-) A-I      intronic chr4:103784319(-) A-I      intronic chr4:103736405(-) A-I      intronic chr4:103733328(-) A-I      intronic chr4:103732776(-) A-I      intronic chr4:103732825(-) A-I      intronic chr4:103779026(-) A-I      intronic chr4:103732716(-) A-I      intronic chr4:103735584(-) A-I      intronic chr4:103733395(-) A-I      intronic chr4:103776716(-) A-I      intronic chr4:103770280(-) A-I      intronic chr4:103736439(-) A-I      intronic chr4:103732441(-) A-I      intronic chr4:103732648(-) A-I      intronic chr4:103776831(-) A-I      intronic chr4:103777401(-) A-I      intronic chr4:103735687(-) A-I      intronic chr4:103731647(-) A-I      intronic chr4:103732408(-) A-I      intronic chr4:103784802(-) A-I      intronic chr4:103767872(-) A-I      intronic chr4:103734422(-) A-I      intronic chr4:103732755(-) A-I      intronic chr4:103755819(-) A-I      intronic chr4:103732375(-) A-I      intronic chr4:103789341(-) A-I      intronic chr4:103735697(-) A-I      intronic chr4:103788847(-) A-I      intronic chr4:103731669(-) A-I      intronic chr4:103732673(-) A-I      intronic chr4:103770328(-) A-I      intronic chr4:103731735(-) A-I      intronic chr4:103770281(-) A-I      intronic chr4:103732301(-) A-I      intronic chr4:103776726(-) A-I      intronic chr4:103755823(-) A-I      intronic chr4:103777360(-) A-I      intronic chr4:103733425(-) A-I      intronic chr4:103788874(-) A-I      intronic chr4:103776830(-) A-I      intronic chr4:103765485(-) A-I      intronic chr4:103731718(-) A-I      intronic chr4:103732302(-) A-I      intronic chr4:103734467(-) A-I      intronic chr4:103788873(-) A-I      intronic chr4:103768938(-) A-I      intronic chr4:103732371(-) A-I      intronic chr4:103784753(-) A-I      intronic chr4:103768874(-) A-I      intronic chr4:103732634(-) A-I      intronic chr4:103736333(-) A-I      intronic chr4:103735574(-) A-I      intronic chr4:103769006(-) A-I      intronic chr4:103732691(-) A-I      intronic chr4:103732613(-) A-I      intronic chr4:103735733(-) A-I      intronic chr4:103731740(-) A-I      intronic chr4:103732815(-) A-I      intronic chr4:103731703(-) A-I      intronic chr4:103732451(-) A-I      intronic chr4:103732651(-) A-I      intronic chr4:103736329(-) A-I      intronic chr4:103731654(-) A-I      intronic chr4:103736268(-) A-I      intronic chr4:103732244(-) A-I      intronic chr4:103732676(-) A-I      intronic chr4:103732420(-) A-I      intronic chr4:103768899(-) A-I      intronic chr4:103732256(-) A-I      intronic chr4:103763539(-) A-I      intronic chr4:103733373(-) A-I      intronic chr4:103732250(-) A-I      intronic chr4:103732803(-) A-I      intronic chr4:103732300(-) A-I      intronic chr4:103735739(-) A-I      intronic chr4:103731739(-) A-I      intronic chr4:103735508(-) A-I      intronic chr4:103767076(-) A-I      intronic chr4:103734455(-) A-I      intronic chr4:103725212(-) A-I      intronic chr4:103735741(-) A-I      intronic chr4:103736365(-) A-I      intronic chr4:103736406(-) A-I      intronic chr4:103732762(-) A-I      intronic chr4:103732714(-) A-I      intronic chr4:103740456(-) A-I      intronic chr4:103736322(-) A-I      intronic chr4:103736306(-) A-I      intronic chr4:103731641(-) A-I      intronic chr4:103774438(-) A-I      intronic chr4:103732635(-) A-I      intronic chr4:103768893(-) A-I      intronic chr4:103732823(-) A-I      intronic chr4:103770322(-) A-I      intronic chr4:103733429(-) A-I      intronic chr4:103732391(-) A-I      intronic chr4:103734481(-) A-I      intronic chr4:103788844(-) A-I      intronic chr4:103784345(-) A-I      intronic chr4:103735486(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	UBE2D3	chr4:103731641(-) A-I intron -    15342557 chr4:103731654(-) A-I intron -    15342557 chr4:103731669(-) A-I intron -    15342557 chr4:103731698(-) A-I intron -    15342557   //21960545 chr4:103731705(-) A-I intron -    15342557 chr4:103732173(-) A-I intron -    15342557 chr4:103732199(-) A-I intron -    15342557 chr4:103732244(-) A-I intron -    15342557 chr4:103732256(-) A-I intron -    15342557 chr4:103732287(-) A-I intron -    15342557 chr4:103732371(-) A-I intron -    15342557 chr4:103732375(-) A-I intron -    15342557 chr4:103732387(-) A-I intron -    15342557 chr4:103732391(-) A-I intron -    15342557 chr4:103732408(-) A-I intron -    15342557 chr4:103732420(-) A-I intron -    15342557 chr4:103732421(-) A-I intron -    15342557 chr4:103732451(-) A-I intron -    15342557 chr4:103732582(-) A-I intron -    15342557 chr4:103732604(-) A-I intron -    15342557 chr4:103732613(-) A-I intron -    15342557 chr4:103732648(-) A-I intron -    15342557 chr4:103732651(-) A-I intron -    15342557 chr4:103732656(-) A-I intron -    15342557 chr4:103732673(-) A-I intron -    15342557 chr4:103732676(-) A-I intron -    15342557 chr4:103732714(-) A-I intron -    15342557 chr4:103732716(-) A-I intron -    15342557 chr4:103732726(-) A-I intron -    15342557 chr4:103732762(-) A-I intron -    15342557 chr4:103732776(-) A-I intron -    15342557 chr4:103732803(-) A-I intron -    15342557 chr4:103732821(-) A-I intron -    15342557   //21960545 chr4:103733328(-) A-I intron -    15342557   //22327324 chr4:103733395(-) A-I intron -    15342557 chr4:103733429(-) A-I intron -    21960545 chr4:103734481(-) A-I intron -    21960545 chr4:103734482(-) A-I intron -    21960545 chr4:103734488(-) A-I intron -    21960545 chr4:103726026(-) T-C intron -    22484847 chr4:103731739(-) A-G intron -    22484847 chr4:103731740(-) A-G intron -    22484847 chr4:103732387(-) A-G intron -    22484847 chr4:103732495(-) A-C intron -    22484847 chr4:103732496(-) C-T intron -    22484847 chr4:103732613(-) A-G intron -    22484847 chr4:103732651(-) A-G intron -    22484847 chr4:103732656(-) A-G intron -    22484847 chr4:103732676(-) A-G intron -    22484847 chr4:103732714(-) A-G intron -    22484847 chr4:103732776(-) A-G intron -    22484847 chr4:103732821(-) A-G intron -    22484847 chr4:103732825(-) A-G intron -    22484847 chr4:103733328(-) A-G intron -    22484847 chr4:103733429(-) A-G intron -    22484847 chr4:103734467(-) A-G intron -    22484847 chr4:103734481(-) A-G intron -    22484847 chr4:103734482(-) A-G intron -    22484847 chr4:103734488(-) A-G intron -    22484847 chr4:103734498(-) A-G intron -    22484847 chr4:103735570(-) A-G intron -    22484847 chr4:103736318(-) T-C intron -    22484847 chr4:103765485(-) A-G intron -    22484847 chr4:103765530(-) A-G intron -    22484847 chr4:103767048(-) T-C intron -    22484847 chr4:103767909(-) T-C intron -    22484847 chr4:103767914(-) T-C intron -    22484847 chr4:103768542(-) T-C intron -    22484847 chr4:103769969(-) A-G intron -    22484847 chr4:103770280(-) A-G intron -    22484847 chr4:103770322(-) A-G intron -    22484847 chr4:103770328(-) A-G intron -    22484847 chr4:103776830(-) A-G intron -    22484847 chr4:103777401(-) A-G intron -    22484847 chr4:103788935(-) A-G intron -    22484847 chr4:103731066(-) C-T intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	UBE2D3	chr4:103715541-103715542(-) m6A 3'UTR       27773535 chr4:103715605-103715606(-) m6A 3'UTR       27773535 chr4:103715653-103715654(-) m6A 3'UTR       27773535 chr4:103715705-103715706(-) m6A 3'UTR       27773535 chr4:103718249-103718250(-) m6A 3'UTR//exon       24284625//24981863//27773535//22608085 chr4:103718255-103718256(-) m6A 3'UTR//exon       24284625//24981863//27773535//22608085 chr4:103718330-103718331(-) m6A 3'UTR//exon       24284625//24981863//28052920//27773535//22608085 chr4:103718343-103718344(-) m6A 3'UTR//exon       24284625//24981863//28052920//27773535//22608085 chr4:103718365-103718366(-) m6A 3'UTR//exon       24284625//25456834//24981863//28052920//27773535//22608085 chr4:103718384-103718385(-) m6A 3'UTR//exon       24284625//25456834//24981863//28052920//27773535//22608085 chr4:103718406-103718407(-) m6A 3'UTR//exon       24284625//25456834//24981863//28052920//27773535//22608085 chr4:103718473-103718474(-) m6A 3'UTR//exon       24284625//24981863//27773535//22608085 chr4:103718527-103718528(-) m6A 3'UTR//exon       24284625//24981863//27773535//22608085 chr4:103718591-103718592(-) m6A 3'UTR//CDS//exon       24284625//24981863//27773535 chr4:103720108-103720109(-) m6A CDS//intron       24284625 chr4:103723726-103723727(-) m6A 3'UTR//CDS//exon       27773535 chr4:103723739-103723740(-) m6A 3'UTR//CDS//exon       27773535 chr4:103730233-103730234(-) m6A 3'UTR//intron       27773535 chr4:103730831-103730832(-) m6A 3'UTR//CDS//exon       - chr4:103731009-103731010(-) m6A 5'UTR//CDS//exon       - chr4:103731074-103731075(-) m6A exon//intron       - chr4:103747715-103747716(-) m6A 5'UTR//exon//intron       24981863//27773535//27371828 chr4:103747758-103747759(-) m6A 5'UTR//exon//intron       24981863//27773535//27371828//22575960 chr4:103747857-103747858(-) m6A 5'UTR//exon//intron       24981863//27773535//27371828//22575960 chr4:103747985-103747986(-) m6A 5'UTR//exon//intron       24284625//24981863//27773535 chr4:103748068-103748069(-) m6A 5'UTR//exon//intron       24284625//24209618//24981863//27773535 chr4:103748191-103748192(-) m6A 5'UTR//intron       24284625//24209618//24981863//27773535 chr4:103748197-103748198(-) m6A 5'UTR//intron       24284625//24209618//24981863//27773535 chr4:103748691-103748692(-) m6A 5'UTR//exon//intron       25456834//24981863//27371828 chr4:103748769-103748770(-) m6A 5'UTR//intron       25456834//24981863//27371828 chr4:103748874-103748875(-) m1A 5'UTR//intron       26863196 chr4:103749091-103749092(-) m6A 5'UTR//intron       24284625//25456834//24981863//22608085 chr4:103749180-103749181(-) m6A 5'UTR//intron       24284625//24981863//22608085 chr4:103749204-103749205(-) m6A 5'UTR//intron       24284625//24981863//22608085 chr4:103749226-103749227(-) m6A 5'UTR//intron       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-365a-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	UBE2D3	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-365a-5p
Interactor2: UBE2D3

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).