Basic Information:

  VIRBase ID:  

HHID00014336

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365a-5p:  MIMAT0009199          PPP1R11:  NM_021959     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-365a-5p	PPP1R11
miRBase Accession/Entrez ID	MIMAT0009199	6992
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CFAP255//HCG-V//HCGV//IPP3//TCTE5//TCTEX5

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-365a-5p	rs1166908611 chr16:14309308    T/C rs1368596991 chr16:14309314    G/A rs1380926089 chr16:14309318    A/G rs1396179427 chr16:14309310    G/C rs1428928383 chr16:14309320    G/A rs773834113 chr16:14309301    G/C

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PPP1R11	chr6:30034903-30034904(+) m6A 5'UTR//intron       - chr6:30034962-30034963(+) m6A 5'UTR//intron       25456834//24981863 chr6:30035115-30035116(+) m6A 5'UTR//intron       24284625//25456834//24981863//27773535 chr6:30035217-30035218(+) m6A 5'UTR//CDS//intron       - chr6:30035229-30035230(+) m6A 5'UTR//CDS//intron       - chr6:30036333-30036334(+) m6A 5'UTR//intron       - chr6:30036370-30036371(+) m6A 5'UTR//CDS       - chr6:30036389-30036390(+) m6A 5'UTR//CDS       - chr6:30036426-30036427(+) m6A 5'UTR//CDS       - chr6:30036442-30036443(+) m6A 5'UTR//CDS       - chr6:30036449-30036450(+) m6A 5'UTR//CDS       - chr6:30036899-30036900(+) m6A CDS       - chr6:30037013-30037014(+) m6A CDS       24284625//24981863 chr6:30037833-30037834(+) m6A 3'UTR       - chr6:30037923-30037924(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-365a-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	PPP1R11	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-365a-5p
Interactor2: PPP1R11

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).