Detail Information

Basic Information:


  VIRBase ID:  

HHID00014332

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365a-5p:           VAMP2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-365a-5p VAMP2
miRBase
Accession/Entrez ID		 MIMAT0009199 6844
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - NEDHAHM//SYB2//VAMP-2

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-365a-5p
rs1166908611 chr16:14309308    T/C
rs1368596991 chr16:14309314    G/A
rs1380926089 chr16:14309318    A/G
rs1396179427 chr16:14309310    G/C
rs1428928383 chr16:14309320    G/A
rs773834113 chr16:14309301    G/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR VAMP2
chr17:8060702(-) A-I      intronic
chr17:8061536(-) A-I      intronic
chr17:8061566(-) A-I      intronic
chr17:8064412(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase VAMP2
chr17:8062578-8062579(-) m6A 3'UTR       -
chr17:8062689-8062690(-) m6A 3'UTR       -
chr17:8062784-8062785(-) m6A 3'UTR       -
chr17:8062823-8062824(-) m6A 3'UTR       -
chr17:8063258-8063259(-) m6A 3'UTR       27773535
chr17:8063328-8063329(-) m6A 3'UTR       27773535
chr17:8063407-8063408(-) m6A 3'UTR       27773535
chr17:8063635-8063636(-) m6A 3'UTR       27773535
chr17:8063698-8063699(-) m6A 3'UTR       24284625//24981863//27773535//27371828
chr17:8064326-8064327(-) m6A 3'UTR//intron       27773535
chr17:8064363-8064364(-) m6A 3'UTR//intron       -
chr17:8064371-8064372(-) m6A 3'UTR//intron       -
chr17:8064475-8064476(-) m6A 3'UTR//intron       27773535
chr17:8064489-8064490(-) m6A 3'UTR//intron       27773535
chr17:8064522-8064523(-) m6A 3'UTR//intron       27773535
chr17:8064552-8064553(-) m6A 3'UTR//intron       27773535
chr17:8064932-8064933(-) m6A CDS       27371828
chr17:8064972-8064973(-) m6A CDS       27371828
chr17:8065037-8065038(-) m6A CDS       24284625//27773535//27371828
chr17:8065055-8065056(-) m6A CDS       24284625//27773535//27371828//27773536
chr17:8065076-8065077(-) m6A 5'UTR//CDS       24284625//27773535//27371828//27773536
chr17:8065586-8065587(-) m6A 5'UTR//CDS       24284625//24981863//27773535//27371828//27773536
chr17:8065596-8065597(-) m6A 5'UTR//CDS       24284625//24981863//27773535//27371828//27773536
chr17:8065615-8065616(-) m6A 5'UTR//CDS       24284625//24981863//27773535//27371828//27773536
chr17:8065764-8065765(-) m6A CDS//intron       24284625//24981863//27371828//27773536
chr17:8065783-8065784(-) m6A 5'UTR//intron       24284625//25456834//24981863//27371828//27773536
chr17:8065824-8065825(-) m6A 5'UTR//intron       24284625//25456834//27371828//27773536
chr17:8065830-8065831(-) m6A 5'UTR//intron       24284625//25456834//27371828//27773536
chr17:8065886-8065887(-) m6A 5'UTR//intron       27371828
chr17:8066815-8066816(-) m6A 5'UTR       24981863
chr17:8066841-8066842(-) m6A 5'UTR       24981863
chr17:8066860-8066861(-) m6A 5'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-365a-5p
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
VAMP2
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells     -
Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-365a-5p
Interactor2: VAMP2

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT//Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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