Basic Information:

  VIRBase ID:  

HHID00014304

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365a-5p:  MIMAT0009199          RYR3:  NM_001036     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-365a-5p	RYR3
miRBase Accession/Entrez ID	MIMAT0009199	6263
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	RYR-3

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-365a-5p	rs1166908611 chr16:14309308    T/C rs1368596991 chr16:14309314    G/A rs1380926089 chr16:14309318    A/G rs1396179427 chr16:14309310    G/C rs1428928383 chr16:14309320    G/A rs773834113 chr16:14309301    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RYR3	chr15:33615027(+) A-I      intronic chr15:33615089(+) A-I      intronic chr15:33615062(+) A-I      intronic chr15:33615061(+) A-I      intronic chr15:33615059(+) A-I      intronic chr15:33663618(+) A-I      intronic chr15:33663621(+) A-I      intronic chr15:33663629(+) A-I      intronic chr15:33615053(+) A-I      intronic chr15:33663622(+) A-I      intronic chr15:34142365(+) A-I      intronic chr15:33618128(+) A-I      intronic chr15:34142403(+) A-I      intronic chr15:34098653(+) A-I      intronic chr15:34048249(+) A-I      intronic chr15:34057153(+) A-I      intronic chr15:33875913(+) A-I      intronic chr15:34142304(+) A-I      intronic chr15:34099172(+) A-I      intronic chr15:34141244(+) A-I      intronic chr15:33875920(+) A-I      intronic chr15:34098974(+) A-I      intronic chr15:34048047(+) A-I      intronic chr15:34142394(+) A-I      intronic chr15:34038824(+) A-I      intronic chr15:34142461(+) A-I      intronic chr15:33875921(+) A-I      intronic chr15:34142430(+) A-I      intronic chr15:34142370(+) A-I      intronic chr15:33860732(+) A-I      intronic chr15:34142404(+) A-I      intronic chr15:33633514(+) A-I      intronic chr15:33860735(+) A-I      intronic chr15:34146270(+) A-I      intronic chr15:33975361(+) A-I      intronic chr15:34098599(+) A-I      intronic chr15:34038835(+) A-I      intronic chr15:33663749(+) A-I      intronic chr15:34146254(+) A-I      intronic chr15:34039247(+) A-I      intronic chr15:33640777(+) A-I      intronic chr15:34098620(+) A-I      intronic chr15:34039246(+) A-I      intronic chr15:34039286(+) A-I      intronic chr15:33633271(+) A-I      intronic chr15:34039277(+) A-I      intronic chr15:33670121(+) A-I      intronic chr15:33615186(+) A-I      intronic chr15:34004403(+) A-I      intronic chr15:34142326(+) A-I      intronic chr15:34002322(+) A-I      intronic chr15:34142418(+) A-I      intronic chr15:34004267(+) A-I      intronic chr15:34098973(+) A-I      intronic chr15:34098612(+) A-I      intronic chr15:33865090(+) A-I      intronic chr15:34142495(+) A-I      intronic chr15:33808737(+) A-I      intronic chr15:34039743(+) A-I      intronic chr15:33629002(+) A-I      intronic chr15:33630353(+) A-I      intronic chr15:33903597(+) A-I      intronic chr15:33663745(+) A-I      intronic chr15:34002609(+) A-I      intronic chr15:34039175(+) A-I      intronic chr15:34005844(+) A-I      intronic chr15:33629003(+) A-I      intronic chr15:34038753(+) A-I      intronic chr15:34142327(+) A-I      intronic chr15:34004201(+) A-I      intronic chr15:33633263(+) A-I      intronic chr15:34099173(+) A-I      intronic chr15:33633475(+) A-I      intronic chr15:34098652(+) A-I      intronic chr15:33732307(+) A-I      intronic chr15:34098598(+) A-I      intronic chr15:34142462(+) A-I      intronic chr15:34002814(+) A-I      intronic chr15:33630420(+) A-I      intronic chr15:34118063(+) A-I      intronic chr15:34002011(+) A-I      intronic chr15:34002321(+) A-I      intronic chr15:34002319(+) A-I      intronic chr15:34038766(+) A-I      intronic chr15:34098616(+) A-I      intronic chr15:34004296(+) A-I      intronic chr15:34098621(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RYR3	chr15:33603294-33603295(+) m6A CDS       - chr15:34130189-34130190(+) m6A CDS       27773535 chr15:34130227-34130228(+) m6A CDS       27773535 chr15:34130258-34130259(+) m6A CDS       27773535 chr15:34130854-34130855(+) m6A CDS       - chr15:34130969-34130970(+) m6A CDS       - chr15:34131113-34131114(+) m6A CDS       24981863//27773535 chr15:34134087-34134088(+) m6A CDS       24981863//27773535 chr15:34134093-34134094(+) m6A CDS       24981863//27773535 chr15:34134125-34134126(+) m6A CDS       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-365a-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	RYR3	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-365a-5p
Interactor2: RYR3

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).