Basic Information:

  VIRBase ID:  

HHID00014293

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365a-5p:  MIMAT0009199          RPL8:  NM_001317771     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-365a-5p	RPL8
miRBase Accession/Entrez ID	MIMAT0009199	6132
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	L8

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-365a-5p	rs1166908611 chr16:14309308    T/C rs1368596991 chr16:14309314    G/A rs1380926089 chr16:14309318    A/G rs1396179427 chr16:14309310    G/C rs1428928383 chr16:14309320    G/A rs773834113 chr16:14309301    G/C

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RPL8	chr8:146015192-146015193(-) m6A 3'UTR//CDS//exon       27773535//22575960 chr8:146015211-146015212(-) m6A 3'UTR//CDS//exon       27773535//22575960 chr8:146015217-146015218(-) m6A 3'UTR//CDS//exon       27773535//22575960 chr8:146015235-146015236(-) m6A 3'UTR//CDS//exon       27773535//22575960 chr8:146015773-146015774(-) m6A 3'UTR//CDS//exon       27773535//22575960 chr8:146015823-146015824(-) m6A 3'UTR//CDS//exon       27773535//22575960 chr8:146016597-146016598(-) m6A exon//intron       22575960 chr8:146016618-146016619(-) m6A exon//intron       22575960 chr8:146016724-146016725(-) m6A CDS//exon//intron       27773535//22575960 chr8:146016733-146016734(-) m6A CDS//exon//intron       27773535//22575960 chr8:146016765-146016766(-) m6A CDS//exon//intron       27773535//22575960 chr8:146016795-146016796(-) m6A CDS//exon//intron       27773535//22575960 chr8:146017297-146017298(-) m6A CDS//exon//intron       22575960 chr8:146017492-146017493(-) Cm CDS//exon//intron       - chr8:146017493-146017494(-) m6A CDS//exon//intron       22575960 chr8:146017523-146017524(-) m6A 5'UTR//exon//intron       22575960 chr8:146017673-146017674(-) m6A 5'UTR//intron       25456834//24981863//27371828//27773536//22575960 chr8:146017679-146017680(-) m6A 5'UTR//intron       25456834//24981863//27371828//27773536//22575960 chr8:146017753-146017754(-) m6A 5'UTR//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-365a-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	RPL8	Chromatin K562 cells     - Cytosol K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells     - Ribosome-free cytosol Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-365a-5p
Interactor2: RPL8

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).