Detail Information

Basic Information:


  VIRBase ID:  

HHID00014290

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365a-5p:           RORC:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-365a-5p RORC
miRBase
Accession/Entrez ID		 MIMAT0009199 6097
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - IMD42//NR1F3//RORG//RZR-GAMMA//RZRG//TOR

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-365a-5p
rs1166908611 chr16:14309308    T/C
rs1368596991 chr16:14309314    G/A
rs1380926089 chr16:14309318    A/G
rs1396179427 chr16:14309310    G/C
rs1428928383 chr16:14309320    G/A
rs773834113 chr16:14309301    G/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR RORC
chr1:151801372(-) A-I      intronic
chr1:151801379(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase RORC
chr1:151779117-151779118(-) m6A 3'UTR       24284625//22575960
chr1:151779125-151779126(-) m6A 3'UTR       24284625//22575960
chr1:151779153-151779154(-) m6A 3'UTR       24284625//22575960
chr1:151779163-151779164(-) m6A 3'UTR       24284625//22575960
chr1:151779186-151779187(-) m6A 3'UTR       24284625//22575960
chr1:151779217-151779218(-) m6A 3'UTR       24284625//22575960
chr1:151779243-151779244(-) m6A 3'UTR       24284625//22575960
chr1:151779249-151779250(-) m6A 3'UTR       24284625//22575960
chr1:151779262-151779263(-) m6A 3'UTR       24284625//22575960
chr1:151779295-151779296(-) m6A 3'UTR       24284625//22575960
chr1:151779461-151779462(-) m6A 3'UTR//exon       24284625
chr1:151779484-151779485(-) m6A 3'UTR//exon       24284625
chr1:151779633-151779634(-) m6A 3'UTR//exon       27371828
chr1:151779639-151779640(-) m6A 3'UTR//exon       27371828
chr1:151779650-151779651(-) m6A 3'UTR//exon       27371828
chr1:151779742-151779743(-) m6A 3'UTR//exon       24284625//25456834//27371828
chr1:151779770-151779771(-) m6A 3'UTR//exon       24284625//25456834//27371828
chr1:151779856-151779857(-) m6A 3'UTR//exon       24284625//25456834//27371828
chr1:151779892-151779893(-) m6A 3'UTR//exon       24284625//25456834//27371828
chr1:151779934-151779935(-) m6A 3'UTR//exon       24284625//25456834//27371828
chr1:151779976-151779977(-) m6A CDS//exon       24284625//25456834//27371828
chr1:151787494-151787495(-) m6A CDS       24284625
chr1:151787509-151787510(-) m6A CDS       24284625
chr1:151789195-151789196(-) m6A CDS       24284625
chr1:151789222-151789223(-) m6A CDS       24284625
chr1:151789719-151789720(-) m6A CDS       27371828
chr1:151798447-151798448(-) m6A 5'UTR//intron       27371828
chr1:151798467-151798468(-) m6A 5'UTR//intron       27371828
chr1:151801913-151801914(-) m6A CDS       27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-365a-5p
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
RORC
Exosome Blood     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-365a-5p
Interactor2: RORC

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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