Basic Information:

  VIRBase ID:  

HHID00014247

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365a-5p:  MIMAT0009199          PIK3CA:  NM_006218     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-365a-5p	PIK3CA
miRBase Accession/Entrez ID	MIMAT0009199	5290
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CLAPO//CLOVE//CWS5//MCAP//MCM//MCMTC//p110-alpha//PI3K//PI3K-alpha

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-365a-5p	rs1166908611 chr16:14309308    T/C rs1368596991 chr16:14309314    G/A rs1380926089 chr16:14309318    A/G rs1396179427 chr16:14309310    G/C rs1428928383 chr16:14309320    G/A rs773834113 chr16:14309301    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PIK3CA	chr3:178923987(+) A-I      intronic chr3:178922873(+) A-I      intronic chr3:178922863(+) A-I      intronic chr3:178922645(+) A-I      intronic chr3:178922642(+) A-I      intronic chr3:178922611(+) A-I      intronic chr3:178914968(+) A-I      intronic chr3:178914966(+) A-I      intronic chr3:178878548(+) A-I      intronic chr3:178909646(+) A-I      intronic chr3:178909631(+) A-I      intronic chr3:178909623(+) A-I      intronic chr3:178892138(+) A-I      intronic chr3:178892139(+) A-I      intronic chr3:178895200(+) A-I      intronic chr3:178895778(+) A-I      intronic chr3:178895794(+) A-I      intronic chr3:178895795(+) A-I      intronic chr3:178922843(+) A-I      intronic chr3:178907008(+) A-I      intronic chr3:178922844(+) A-I      intronic chr3:178922855(+) A-I      intronic chr3:178922886(+) A-I      intronic chr3:178906821(+) A-I      intronic chr3:178905215(+) A-I      intronic chr3:178880199(+) A-I      intronic chr3:178883249(+) A-I      intronic chr3:178891619(+) A-I      intronic chr3:178891670(+) A-I      intronic chr3:178892081(+) A-I      intronic chr3:178895201(+) A-I      intronic chr3:178895218(+) A-I      intronic chr3:178925721(+) A-I      intronic chr3:178905205(+) A-I      intronic chr3:178905179(+) A-I      intronic chr3:178905146(+) A-I      intronic chr3:178905138(+) A-I      intronic chr3:178895766(+) A-I      intronic chr3:178892095(+) A-I      intronic chr3:178950775(+) A-I      intronic chr3:178950811(+) A-I      intronic chr3:178950844(+) A-I      intronic chr3:178950875(+) A-I      intronic chr3:178895734(+) A-I      intronic chr3:178878471(+) A-I      intronic chr3:178925689(+) A-I      intronic chr3:178892080(+) A-I      intronic chr3:178924722(+) A-I      intronic chr3:178924055(+) A-I      intronic chr3:178950726(+) A-I      intronic chr3:178950715(+) A-I      intronic chr3:178929961(+) A-I      intronic chr3:178929925(+) A-I      intronic chr3:178929896(+) A-I      intronic chr3:178929859(+) A-I      intronic chr3:178929857(+) A-I      intronic chr3:178929852(+) A-I      intronic chr3:178929844(+) A-I      intronic chr3:178929272(+) A-I      intronic chr3:178895827(+) A-I      intronic chr3:178891563(+) A-I      intronic chr3:178950827(+) A-I      intronic chr3:178920018(+) A-I      intronic chr3:178924583(+) A-I      intronic chr3:178905688(+) A-I      intronic chr3:178892203(+) A-I      intronic chr3:178930144(+) A-I      intronic chr3:178883231(+) A-I      intronic chr3:178895335(+) A-I      intronic chr3:178923946(+) A-I      intronic chr3:178892020(+) A-I      intronic chr3:178950750(+) A-I      intronic chr3:178891246(+) A-I      intronic chr3:178895375(+) A-I      intronic chr3:178895845(+) A-I      intronic chr3:178891615(+) A-I      intronic chr3:178895242(+) A-I      intronic chr3:178925582(+) A-I      intronic chr3:178891654(+) A-I      intronic chr3:178900315(+) A-I      intronic chr3:178895171(+) A-I      intronic chr3:178892004(+) A-I      intronic chr3:178891571(+) A-I      intronic chr3:178930307(+) A-I      intronic chr3:178939731(+) A-I      intronic chr3:178895986(+) A-I      intronic chr3:178948457(+) A-I      intronic chr3:178930490(+) A-I      intronic chr3:178930497(+) A-I      intronic chr3:178879299(+) A-I      intronic chr3:178905555(+) A-I      intronic chr3:178948288(+) A-I      intronic chr3:178892129(+) A-I      intronic chr3:178924585(+) A-I      intronic chr3:178891531(+) A-I      intronic chr3:178905071(+) A-I      intronic chr3:178948400(+) A-I      intronic chr3:178892112(+) A-I      intronic chr3:178883212(+) A-I      intronic chr3:178919610(+) A-I      intronic chr3:178882400(+) A-I      intronic chr3:178923905(+) A-I      intronic chr3:178891982(+) A-I      intronic chr3:178891256(+) A-I      intronic chr3:178925740(+) A-I      intronic chr3:178895181(+) A-I      intronic chr3:178892073(+) A-I      intronic chr3:178950749(+) A-I      intronic chr3:178922593(+) A-I      intronic chr3:178905687(+) A-I      intronic chr3:178905705(+) A-I      intronic chr3:178891252(+) A-I      intronic chr3:178925488(+) A-I      intronic chr3:178924030(+) A-I      intronic chr3:178895321(+) A-I      intronic chr3:178948382(+) A-I      intronic chr3:178930250(+) A-I      intronic chr3:178895951(+) A-I      intronic chr3:178922594(+) A-I      intronic chr3:178929258(+) A-I      intronic chr3:178883283(+) A-I      intronic chr3:178950909(+) A-I      intronic chr3:178950908(+) A-I      intronic chr3:178909694(+) A-I      intronic chr3:178900358(+) A-I      intronic chr3:178905064(+) A-I      intronic chr3:178895362(+) A-I      intronic chr3:178891078(+) A-I      intronic chr3:178895284(+) A-I      intronic chr3:178895381(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PIK3CA	chr3:178878561(+) A-I intron -    19478186 chr3:178878370(+) A-I intron -    21960545 chr3:178878469(+) A-I intron -    21960545 chr3:178879299(+) A-G intron -    22484847 chr3:178891165(+) A-G intron -    22484847 chr3:178891531(+) A-G intron -    22484847 chr3:178891563(+) A-G intron -    22484847 chr3:178891571(+) A-G intron -    22484847 chr3:178891579(+) A-G intron -    22484847 chr3:178891615(+) A-G intron -    22484847 chr3:178891644(+) A-G intron -    22484847 chr3:178891654(+) A-G intron -    22484847 chr3:178891681(+) A-G intron -    22484847 chr3:178892003(+) A-G intron -    22484847 chr3:178892004(+) A-G intron -    22484847 chr3:178892020(+) A-G intron -    22484847 chr3:178892073(+) A-G intron -    22484847 chr3:178892075(+) A-G intron -    22484847 chr3:178892112(+) A-G intron -    22484847 chr3:178892129(+) A-G intron -    22484847 chr3:178892199(+) A-G intron -    22484847 chr3:178892203(+) A-G intron -    22484847 chr3:178895242(+) A-G intron -    22484847 chr3:178895281(+) A-G intron -    22484847 chr3:178895301(+) A-G intron -    22484847 chr3:178895321(+) A-G intron -    22484847 chr3:178895335(+) A-G intron -    22484847 chr3:178895381(+) A-G intron -    22484847 chr3:178895772(+) A-G intron -    22484847 chr3:178895827(+) A-G intron -    22484847 chr3:178895986(+) A-G intron -    22484847 chr3:178900254(+) A-G intron -    22484847 chr3:178900315(+) A-G intron -    22484847 chr3:178905064(+) A-G intron -    22484847 chr3:178905555(+) A-G intron -    22484847 chr3:178915058(+) C-A intron -    22484847 chr3:178924445(+) A-G intron -    22484847 chr3:178925582(+) A-G intron -    22484847 chr3:178925694(+) A-G intron -    22484847 chr3:178929258(+) A-G intron -    22484847 chr3:178929895(+) A-G intron -    22484847 chr3:178930307(+) A-G intron -    22484847 chr3:178948294(+) A-G intron -    22484847 chr3:178948457(+) A-G intron -    22484847 chr3:178950694(+) A-G intron -    22484847 chr3:178950749(+) A-G intron -    22484847 chr3:178950827(+) A-G intron -    22484847 chr3:178878545(+) A-G intron -    22484847 chr3:178878561(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PIK3CA	chr3:178916593-178916594(+) m6A 5'UTR       24284625//22608085 chr3:178916610-178916611(+) m6A 5'UTR       24284625//22608085 chr3:178916639-178916640(+) m6A CDS       24284625//24209618//24981863//22608085 chr3:178916756-178916757(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr3:178916868-178916869(+) m6A CDS       24209618//24981863//22608085 chr3:178916921-178916922(+) m6A CDS       24981863 chr3:178919168-178919169(+) m6A CDS       24981863 chr3:178948147-178948148(+) m6A CDS       22608085 chr3:178951980-178951981(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr3:178952017-178952018(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr3:178952035-178952036(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr3:178952067-178952068(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr3:178952098-178952099(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:178952133-178952134(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr3:178952147-178952148(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr3:178952224-178952225(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr3:178952255-178952256(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr3:178952279-178952280(+) m6A 3'UTR       24284625//24981863//22575960//22608085 chr3:178952321-178952322(+) m6A 3'UTR       24284625//24981863//22608085 chr3:178952342-178952343(+) m6A 3'UTR       24284625//24981863//22608085 chr3:178953288-178953289(+) m6A 3'UTR       27773535 chr3:178953409-178953410(+) m6A 3'UTR       24981863 chr3:178953430-178953431(+) m6A 3'UTR       24981863 chr3:178954468-178954469(+) m6A 3'UTR       27773535 chr3:178954856-178954857(+) m6A 3'UTR       27773535 chr3:178955864-178955865(+) m6A 3'UTR       27773535 chr3:178957731-178957732(+) m6A 3'UTR       27773535 chr3:178957805-178957806(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-365a-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	PIK3CA	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-365a-5p
Interactor2: PIK3CA

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).