Basic Information:

  VIRBase ID:  

HHID00014243

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365a-5p:  MIMAT0009199          PGAM1:  NM_002629     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-365a-5p	PGAM1
miRBase Accession/Entrez ID	MIMAT0009199	5223
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	HEL-S-35//PGAM-B//PGAMA

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-365a-5p	rs1166908611 chr16:14309308    T/C rs1368596991 chr16:14309314    G/A rs1380926089 chr16:14309318    A/G rs1396179427 chr16:14309310    G/C rs1428928383 chr16:14309320    G/A rs773834113 chr16:14309301    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PGAM1	chr10:99189706(+) A-I      intronic chr10:99188884(+) A-I      intronic chr10:99189647(+) A-I      intronic chr10:99189651(+) A-I      intronic chr10:99189813(+) A-I      intronic chr10:99188925(+) A-I      intronic chr10:99189650(+) A-I      intronic chr10:99189812(+) A-I      intronic chr10:99189748(+) A-I      intronic chr10:99189724(+) A-I      intronic chr10:99189682(+) A-I      intronic chr10:99189809(+) A-I      intronic chr10:99189715(+) A-I      intronic chr10:99189758(+) A-I      intronic chr10:99189617(+) A-I      intronic chr10:99189662(+) A-I      intronic chr10:99189627(+) A-I      intronic chr10:99189649(+) A-I      intronic chr10:99189744(+) A-I      intronic chr10:99189123(+) A-I      intronic chr10:99188930(+) A-I      intronic chr10:99189753(+) A-I      intronic chr10:99191594(+) A-I      intronic chr10:99189652(+) A-I      intronic chr10:99189656(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PGAM1	chr10:99189617(+) A-I intron -    22327324 chr10:99189656(+) A-I intron -    22327324 chr10:99189812(+) A-I intron -    22327324 chr10:99189617(+) A-G intron -    22484847 chr10:99189652(+) A-G intron -    22484847 chr10:99189656(+) A-G intron -    22484847 chr10:99189809(+) A-G intron -    22484847 chr10:99189812(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PGAM1	chr10:99185951-99185952(+) m6A 5'UTR       25456834//24981863//22608085 chr10:99185968-99185969(+) m6A 5'UTR       25456834//24981863//22608085 chr10:99186078-99186079(+) m6A CDS//exon       25456834//24981863 chr10:99186113-99186114(+) m6A CDS//exon       24981863//22575960 chr10:99186122-99186123(+) m6A CDS//exon       24981863//22575960 chr10:99190191-99190192(+) m6A CDS//exon       - chr10:99190200-99190201(+) m6A CDS//exon       - chr10:99190302-99190303(+) m6A CDS//exon       - chr10:99190727-99190728(+) m6A CDS//exon       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-365a-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	PGAM1	Chromatin K562 cells     - Cytosol K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-365a-5p
Interactor2: PGAM1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).