Detail Information

Basic Information:


  VIRBase ID:  

HHID00014209

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365a-5p:           MOCS2:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-365a-5p MOCS2
miRBase
Accession/Entrez ID		 MIMAT0009199 4338
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - MCBPE//MOCO1//MOCODB//MPTS

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-365a-5p
rs1166908611 chr16:14309308    T/C
rs1368596991 chr16:14309314    G/A
rs1380926089 chr16:14309318    A/G
rs1396179427 chr16:14309310    G/C
rs1428928383 chr16:14309320    G/A
rs773834113 chr16:14309301    G/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR MOCS2
chr5:52398558(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MOCS2
chr5:52391529-52391530(-) m6A 3'UTR       27773535
chr5:52391542-52391543(-) m6A 3'UTR       27773535
chr5:52393415-52393416(-) m6A 3'UTR       27773535
chr5:52393915-52393916(-) m6A 3'UTR//exon       27773535
chr5:52393921-52393922(-) m6A 3'UTR//exon       27773535
chr5:52393967-52393968(-) m6A 3'UTR//exon       27773535
chr5:52393996-52393997(-) m6A 3'UTR//exon       27773535
chr5:52394174-52394175(-) m6A 3'UTR//exon       24981863//26404942//27773535
chr5:52394226-52394227(-) m6A 3'UTR//exon       24981863//27773535
chr5:52394244-52394245(-) m6A 3'UTR//exon       24981863//27773535
chr5:52394308-52394309(-) m6A 3'UTR//exon       24981863//27773535
chr5:52394390-52394391(-) m6A 3'UTR//exon       27773535
chr5:52405166-52405167(-) m6A 5'UTR//intron       24981863
chr5:52405284-52405285(-) m6A 5'UTR//intron       24981863
chr5:52405314-52405315(-) m6A 5'UTR//intron       24981863//27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-365a-5p
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
MOCS2
Exosome Blood     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-365a-5p
Interactor2: MOCS2

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence miRDB//Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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