Basic Information:

  VIRBase ID:  

HHID00014179

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365a-5p:  MIMAT0009199          IREB2:  NM_001320941     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-365a-5p	IREB2
miRBase Accession/Entrez ID	MIMAT0009199	3658
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ACO3//IRE-BP 2//IRE-BP2//IRP2//IRP2AD//NDCAMA

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-365a-5p	rs1166908611 chr16:14309308    T/C rs1368596991 chr16:14309314    G/A rs1380926089 chr16:14309318    A/G rs1396179427 chr16:14309310    G/C rs1428928383 chr16:14309320    G/A rs773834113 chr16:14309301    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	IREB2	chr15:78773086(+) A-I      intronic chr15:78773129(+) A-I      intronic chr15:78759814(+) A-I      intronic chr15:78759756(+) A-I      intronic chr15:78759477(+) A-I      intronic chr15:78755708(+) A-I      intronic chr15:78755703(+) A-I      intronic chr15:78755702(+) A-I      intronic chr15:78755526(+) A-I      intronic chr15:78750885(+) A-I      intronic chr15:78750832(+) A-I      intronic chr15:78748973(+) A-I      intronic chr15:78748853(+) A-I      intronic chr15:78782114(+) A-I      intronic chr15:78782105(+) A-I      intronic chr15:78781444(+) A-I      intronic chr15:78779148(+) A-I      intronic chr15:78779115(+) A-I      intronic chr15:78779035(+) A-I      intronic chr15:78779031(+) A-I      intronic chr15:78778694(+) A-I      intronic chr15:78775229(+) A-I      intronic chr15:78775207(+) A-I      intronic chr15:78774429(+) A-I      intronic chr15:78774425(+) A-I      intronic chr15:78774028(+) A-I      intronic chr15:78773853(+) A-I      intronic chr15:78773625(+) A-I      intronic chr15:78773600(+) A-I      intronic chr15:78773240(+) A-I      intronic chr15:78773220(+) A-I      intronic chr15:78773127(+) A-I      intronic chr15:78772994(+) A-I      intronic chr15:78772988(+) A-I      intronic chr15:78772208(+) A-I      intronic chr15:78771536(+) A-I      intronic chr15:78770929(+) A-I      intronic chr15:78770866(+) A-I      intronic chr15:78763590(+) A-I      intronic chr15:78762007(+) A-I      intronic chr15:78761958(+) A-I      intronic chr15:78761944(+) A-I      intronic chr15:78761938(+) A-I      intronic chr15:78761806(+) A-I      intronic chr15:78761800(+) A-I      intronic chr15:78760281(+) A-I      intronic chr15:78760225(+) A-I      intronic chr15:78759848(+) A-I      intronic chr15:78759846(+) A-I      intronic chr15:78761915(+) A-I      intronic chr15:78759501(+) A-I      intronic chr15:78764970(+) A-I      intronic chr15:78782127(+) A-I      intronic chr15:78759441(+) A-I      intronic chr15:78748957(+) A-I      intronic chr15:78771344(+) A-I      intronic chr15:78773837(+) A-I      intronic chr15:78782553(+) A-I      intronic chr15:78763418(+) A-I      intronic chr15:78761986(+) A-I      intronic chr15:78761865(+) A-I      intronic chr15:78773356(+) A-I      intronic chr15:78760679(+) A-I      intronic chr15:78751240(+) A-I      intronic chr15:78773526(+) A-I      intronic chr15:78756080(+) A-I      intronic chr15:78779091(+) A-I      intronic chr15:78775115(+) A-I      intronic chr15:78761945(+) A-I      intronic chr15:78759912(+) A-I      intronic chr15:78759458(+) A-I      intronic chr15:78778853(+) A-I      intronic chr15:78759890(+) A-I      intronic chr15:78748878(+) A-I      intronic chr15:78781306(+) A-I      intronic chr15:78760649(+) A-I      intronic chr15:78760431(+) A-I      intronic chr15:78772156(+) A-I      intronic chr15:78788661(+) A-I      intronic chr15:78744993(+) A-I      intronic chr15:78759304(+) A-I      intronic chr15:78759869(+) A-I      intronic chr15:78747825(+) A-I      intronic chr15:78772126(+) A-I      intronic chr15:78759437(+) A-I      intronic chr15:78773762(+) A-I      intronic chr15:78778804(+) A-I      intronic chr15:78778794(+) A-I      intronic chr15:78773293(+) A-I      intronic chr15:78743400(+) A-I      intronic chr15:78747221(+) A-I      intronic chr15:78773140(+) A-I      intronic chr15:78774414(+) A-I      intronic chr15:78763301(+) A-I      intronic chr15:78781330(+) A-I      intronic chr15:78763586(+) A-I      intronic chr15:78763531(+) A-I      intronic chr15:78782497(+) A-I      intronic chr15:78760014(+) A-I      intronic chr15:78773519(+) A-I      intronic chr15:78771328(+) A-I      intronic chr15:78748880(+) A-I      intronic chr15:78747136(+) A-I      intronic chr15:78778748(+) A-I      intronic chr15:78747103(+) A-I      intronic chr15:78745289(+) A-I      intronic chr15:78756079(+) A-I      intronic chr15:78763622(+) A-I      intronic chr15:78781333(+) A-I      intronic chr15:78773424(+) A-I      intronic chr15:78763154(+) A-I      intronic chr15:78763483(+) A-I      intronic chr15:78760848(+) A-I      intronic chr15:78772116(+) A-I      intronic chr15:78748953(+) A-I      intronic chr15:78759913(+) A-I      intronic chr15:78773409(+) A-I      intronic chr15:78763246(+) A-I      intronic chr15:78745073(+) A-I      intronic chr15:78778876(+) A-I      intronic chr15:78747862(+) A-I      intronic chr15:78748772(+) A-I      intronic chr15:78773331(+) A-I      intronic chr15:78744994(+) A-I      intronic chr15:78760407(+) A-I      intronic chr15:78747067(+) A-I      intronic chr15:78790248(+) A-I      intronic chr15:78760233(+) A-I      intronic chr15:78759445(+) A-I      intronic chr15:78779129(+) A-I      intronic chr15:78774451(+) A-I      intronic chr15:78759473(+) A-I      intronic chr15:78773791(+) A-I      intronic chr15:78770023(+) A-I      intronic chr15:78747169(+) A-I      intronic chr15:78774329(+) A-I      intronic chr15:78779201(+) A-I      intronic chr15:78771576(+) A-I      intronic chr15:78771051(+) A-I      intronic chr15:78759939(+) A-I      intronic chr15:78774390(+) A-I      intronic chr15:78771320(+) A-I      intronic chr15:78747279(+) A-I      intronic chr15:78747839(+) A-I      intronic chr15:78763534(+) A-I      intronic chr15:78773832(+) A-I      intronic chr15:78773120(+) A-I      intronic chr15:78771023(+) A-I      intronic chr15:78763407(+) A-I      intronic chr15:78773471(+) A-I      intronic chr15:78774473(+) A-I      intronic chr15:78760655(+) A-I      intronic chr15:78781290(+) A-I      intronic chr15:78770930(+) A-I      intronic chr15:78776205(+) A-I      intronic chr15:78760238(+) A-I      intronic chr15:78773470(+) A-I      intronic chr15:78761985(+) A-I      intronic chr15:78779192(+) A-I      intronic chr15:78759303(+) A-I      intronic chr15:78759873(+) A-I      intronic chr15:78748888(+) A-I      intronic chr15:78760019(+) A-I      intronic chr15:78761954(+) A-I      intronic chr15:78755519(+) A-I      intronic chr15:78778788(+) A-I      intronic chr15:78781443(+) A-I      intronic chr15:78773536(+) A-I      intronic chr15:78747260(+) A-I      intronic chr15:78773164(+) A-I      intronic chr15:78763106(+) A-I      intronic chr15:78759295(+) A-I      intronic chr15:78761807(+) A-I      intronic chr15:78747175(+) A-I      intronic chr15:78779124(+) A-I      intronic chr15:78761971(+) A-I      intronic chr15:78760715(+) A-I      intronic chr15:78759500(+) A-I      intronic chr15:78773128(+) A-I      intronic chr15:78781307(+) A-I      intronic chr15:78764971(+) A-I      intronic chr15:78747110(+) A-I      intronic chr15:78772834(+) A-I      intronic chr15:78773230(+) A-I      intronic chr15:78747162(+) A-I      intronic chr15:78792378(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	IREB2	chr15:78747279(+) A-G intron -    22484847 chr15:78761807(+) A-G intron -    22484847 chr15:78763407(+) A-G intron -    22484847 chr15:78773230(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	IREB2	chr15:78730519-78730520(+) m6A 5'UTR//intron       24981863 chr15:78762914-78762915(+) Gm 3'UTR//CDS//exon//intron       - chr15:78789596-78789597(+) m6A 3'UTR//CDS       24284625//24981863//22608085 chr15:78789622-78789623(+) m6A 3'UTR//CDS       24284625//24981863//22575960//22608085 chr15:78790442-78790443(+) m6A 3'UTR//CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr15:78790459-78790460(+) m6A 3'UTR//CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr15:78790542-78790543(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr15:78790723-78790724(+) m6A 3'UTR       24284625//24981863//27773535//22608085 chr15:78790759-78790760(+) m6A 3'UTR       24284625//24981863//27773535//22608085 chr15:78790845-78790846(+) m6A 3'UTR       24209618//24981863//22608085 chr15:78790906-78790907(+) m6A 3'UTR       24981863//22608085 chr15:78790946-78790947(+) m6A 3'UTR       24981863//22608085 chr15:78790986-78790987(+) m6A 3'UTR       24981863//22608085 chr15:78791863-78791864(+) m6A 3'UTR       24981863//22608085 chr15:78791871-78791872(+) m6A 3'UTR       24981863//22608085 chr15:78791885-78791886(+) m6A 3'UTR       24981863//22608085 chr15:78791895-78791896(+) m6A 3'UTR       24981863//22608085 chr15:78791949-78791950(+) m6A 3'UTR       24981863//22608085 chr15:78791961-78791962(+) m6A 3'UTR       24981863//22608085 chr15:78792096-78792097(+) m6A 3'UTR       - chr15:78792183-78792184(+) m6A 3'UTR       - chr15:78793351-78793352(+) Y 3'UTR       26075521 chr15:78793567-78793568(+) m6A 3'UTR       27773535 chr15:78793623-78793624(+) m6A 3'UTR       27773535 chr15:78793658-78793659(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-365a-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	IREB2	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Colon cancer cells     24393600 Nucleus HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-365a-5p
Interactor2: IREB2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).