Detail Information

Basic Information:


  VIRBase ID:  

HHID00014175

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365a-5p:           IL2RA:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-365a-5p IL2RA
miRBase
Accession/Entrez ID		 MIMAT0009199 3559
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CD25//IDDM10//IL2R//IMD41//p55//TCGFR

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-365a-5p
rs1166908611 chr16:14309308    T/C
rs1368596991 chr16:14309314    G/A
rs1380926089 chr16:14309318    A/G
rs1396179427 chr16:14309310    G/C
rs1428928383 chr16:14309320    G/A
rs773834113 chr16:14309301    G/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR IL2RA
chr10:6092355(-) A-I      intronic
chr10:6092371(-) A-I      intronic
chr10:6092374(-) A-I      intronic
chr10:6092397(-) A-I      intronic
chr10:6093485(-) A-I      intronic
chr10:6092459(-) A-I      intronic
chr10:6096946(-) A-I      intronic
chr10:6093629(-) A-I      intronic
chr10:6093770(-) A-I      intronic
chr10:6058564(-) A-I      intronic
chr10:6070875(-) A-I      intronic
chr10:6070886(-) A-I      intronic
chr10:6096876(-) A-I      intronic
chr10:6071736(-) A-I      intronic
chr10:6071837(-) A-I      intronic
chr10:6071891(-) A-I      intronic
chr10:6096933(-) A-I      intronic
chr10:6071935(-) A-I      intronic
chr10:6092343(-) A-I      intronic
chr10:6096877(-) A-I      intronic
chr10:6098532(-) A-I      intronic
chr10:6095708(-) A-I      intronic
chr10:6085539(-) A-I      intronic
chr10:6075096(-) A-I      intronic
chr10:6075169(-) A-I      intronic
chr10:6055917(-) A-I      intronic
chr10:6070876(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase IL2RA
chr10:6053305-6053306(-) m6A 3'UTR       -
chr10:6053318-6053319(-) m6A 3'UTR       -
chr10:6053481-6053482(-) m6A 3'UTR       -
chr10:6053509-6053510(-) m6A 3'UTR       -
chr10:6054576-6054577(-) m6A 3'UTR       27371828
chr10:6054681-6054682(-) m6A 3'UTR       27371828
chr10:6054732-6054733(-) m6A 3'UTR       27371828
chr10:6054793-6054794(-) m6A 3'UTR       27371828
chr10:6054821-6054822(-) m6A 3'UTR       27371828
chr10:6054830-6054831(-) m6A 3'UTR       27371828
chr10:6063642-6063643(-) m6A CDS//intron       27371828
chr10:6066223-6066224(-) m6A CDS       27371828
chr10:6066257-6066258(-) m6A CDS       27371828
chr10:6066273-6066274(-) m6A CDS       27371828
chr10:6067909-6067910(-) m6A CDS       27371828
chr10:6067919-6067920(-) m6A CDS       27371828
chr10:6104087-6104088(-) m6A CDS       27371828
chr10:6104155-6104156(-) m6A 5'UTR       27371828
chr10:6104232-6104233(-) m6A 5'UTR       27371828
chr10:6104258-6104259(-) m6A 5'UTR       27371828
chr10:6104267-6104268(-) m6A 5'UTR       27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-365a-5p
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
IL2RA
Exosome Blood     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-365a-5p
Interactor2: IL2RA

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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