Basic Information:

  VIRBase ID:  

HHID00014106

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365a-5p:  MIMAT0009199          EPOR:  NR_033663     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-365a-5p	EPOR
miRBase Accession/Entrez ID	MIMAT0009199	2057
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	EPO-R

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-365a-5p	rs1166908611 chr16:14309308    T/C rs1368596991 chr16:14309314    G/A rs1380926089 chr16:14309318    A/G rs1396179427 chr16:14309310    G/C rs1428928383 chr16:14309320    G/A rs773834113 chr16:14309301    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	EPOR	chr19:11490108(-) A-I      intronic chr19:11490129(-) A-I      intronic chr19:11490053(-) A-I      intronic chr19:11489767(-) A-I      intronic chr19:11490580(-) A-I      intronic chr19:11490572(-) A-I      intronic chr19:11490570(-) A-I      intronic chr19:11490066(-) A-I      intronic chr19:11490244(-) A-I      intronic chr19:11490248(-) A-I      intronic chr19:11490055(-) A-I      intronic chr19:11490109(-) A-I      intronic chr19:11490090(-) A-I      intronic chr19:11490054(-) A-I      intronic chr19:11490571(-) A-I      intronic chr19:11490139(-) A-I      intronic chr19:11490150(-) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	EPOR	chr19:11488286-11488287(-) m6A 3'UTR       27773535 chr19:11488413-11488414(-) m6A 3'UTR       27773535 chr19:11488514-11488515(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22608085 chr19:11488588-11488589(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr19:11488597-11488598(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr19:11488604-11488605(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr19:11488614-11488615(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr19:11488657-11488658(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr19:11488714-11488715(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr19:11488771-11488772(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr19:11488868-11488869(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr19:11488897-11488898(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr19:11489008-11489009(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22608085 chr19:11489035-11489036(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr19:11489050-11489051(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr19:11489071-11489072(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr19:11489141-11489142(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22608085 chr19:11489209-11489210(-) m6A 3'UTR//CDS//exon       24284625//25456834//27371828//22608085 chr19:11489310-11489311(-) m6A CDS//exon//intron       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-365a-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	EPOR	Chromatin K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-365a-5p
Interactor2: EPOR

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).