Detail Information

Basic Information:


  VIRBase ID:  

HHID00014097

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365a-5p:           PHC2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-365a-5p PHC2
miRBase
Accession/Entrez ID		 MIMAT0009199 1912
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - EDR2//HPH2//PH2

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-365a-5p
rs1166908611 chr16:14309308    T/C
rs1368596991 chr16:14309314    G/A
rs1380926089 chr16:14309318    A/G
rs1396179427 chr16:14309310    G/C
rs1428928383 chr16:14309320    G/A
rs773834113 chr16:14309301    G/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PHC2
chr1:33813297(-) A-I      intronic
chr1:33813967(-) A-I      intronic
chr1:33801686(-) A-I      intronic
chr1:33801763(-) A-I      intronic
chr1:33801662(-) A-I      intronic
chr1:33801338(-) A-I      intronic
chr1:33801373(-) A-I      intronic
chr1:33801379(-) A-I      intronic
chr1:33801401(-) A-I      intronic
chr1:33801419(-) A-I      intronic
chr1:33801439(-) A-I      intronic
chr1:33801456(-) A-I      intronic
chr1:33801657(-) A-I      intronic
chr1:33801722(-) A-I      intronic
chr1:33801727(-) A-I      intronic
chr1:33808989(-) A-I      intronic
chr1:33808882(-) A-I      intronic
chr1:33801846(-) A-I      intronic
chr1:33801793(-) A-I      intronic
chr1:33801783(-) A-I      intronic
chr1:33794090(-) A-I      intronic
chr1:33801760(-) A-I      intronic
chr1:33801418(-) A-I      intronic
chr1:33792396(-) A-I      intronic
chr1:33810303(-) A-I      intronic
chr1:33801495(-) A-I      intronic
chr1:33801258(-) A-I      intronic
chr1:33801728(-) A-I      intronic
chr1:33801675(-) A-I      intronic
chr1:33801432(-) A-I      intronic
chr1:33801259(-) A-I      intronic
chr1:33801862(-) A-I      intronic
chr1:33801389(-) A-I      intronic
chr1:33801758(-) A-I      intronic
chr1:33801333(-) A-I      intronic
chr1:33794096(-) A-I      intronic
chr1:33792434(-) A-I      intronic
chr1:33810351(-) A-I      intronic
chr1:33801309(-) A-I      intronic
chr1:33808971(-) A-I      intronic
chr1:33801335(-) A-I      intronic
chr1:33801679(-) A-I      intronic
chr1:33801650(-) A-I      intronic
chr1:33792351(-) A-I      intronic
chr1:33810409(-) A-I      intronic
chr1:33801738(-) A-I      intronic
chr1:33801754(-) A-I      intronic
chr1:33801836(-) A-I      intronic
chr1:33801767(-) A-I      intronic
chr1:33794060(-) A-I      intronic
chr1:33794092(-) A-I      intronic
chr1:33801714(-) A-I      intronic
chr1:33801854(-) A-I      intronic
chr1:33801784(-) A-I      intronic
chr1:33810329(-) A-I      intronic
chr1:33809433(-) A-I      intronic
chr1:33801415(-) A-I      intronic
chr1:33801296(-) A-I      intronic
chr1:33801857(-) A-I      intronic
chr1:33801344(-) A-I      intronic
chr1:33808962(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED PHC2
chr1:33801495(-) A-G intron -    22484847
chr1:33801650(-) A-G intron -    22484847
chr1:33801714(-) A-G intron -    22484847
chr1:33801738(-) A-G intron -    22484847
chr1:33801758(-) A-G intron -    22484847
chr1:33808962(-) A-G intron -    22484847
chr1:33808971(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PHC2
chr1:33789274-33789275(-) m6A 3'UTR//exon       27773535
chr1:33789505-33789506(-) m6A 3'UTR//exon       24284625
chr1:33789522-33789523(-) m6A 3'UTR//exon       -
chr1:33789680-33789681(-) m6A 3'UTR//exon       27773535
chr1:33789777-33789778(-) m6A 3'UTR//exon       27773535
chr1:33789802-33789803(-) m6A 3'UTR//exon       27773535
chr1:33789856-33789857(-) m6A 3'UTR//exon       27773535
chr1:33790406-33790407(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:33790472-33790473(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:33790526-33790527(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr1:33790547-33790548(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr1:33794543-33794544(-) m6A CDS//exon       27773535
chr1:33794559-33794560(-) m6A CDS//exon       27773535
chr1:33794589-33794590(-) m6A CDS//exon       27773535
chr1:33794648-33794649(-) m6A CDS//exon       27773535
chr1:33794685-33794686(-) m6A CDS//exon       27773535
chr1:33795768-33795769(-) m6A CDS//exon       27773535
chr1:33795782-33795783(-) m6A CDS//exon       27773535
chr1:33797936-33797937(-) m6A CDS//exon       27773535
chr1:33799449-33799450(-) m6A exon//intron       27773535
chr1:33799476-33799477(-) m6A exon//intron       27773535
chr1:33799753-33799754(-) m6A CDS//exon//intron       -
chr1:33799774-33799775(-) m6A CDS//exon//intron       -
chr1:33799823-33799824(-) m6A CDS//exon       -
chr1:33799890-33799891(-) m6A 5'UTR//CDS//exon       24209618
chr1:33800831-33800832(-) m6A exon//intron       24209618
chr1:33800839-33800840(-) m6A exon//intron       24209618
chr1:33815200-33815201(-) m6A 5'UTR//exon//intron       24209618
chr1:33815271-33815272(-) m6A 5'UTR//exon//intron       24209618
chr1:33818863-33818864(-) m6A exon//intron       27773535
chr1:33818874-33818875(-) m6A exon//intron       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-365a-5p
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
PHC2
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-365a-5p
Interactor2: PHC2

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT//Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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