Detail Information

Basic Information:


  VIRBase ID:  

HHID00014075

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365a-5p:           CSNK1E:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-365a-5p CSNK1E
miRBase
Accession/Entrez ID		 MIMAT0009199 1454
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CKIe//CKIepsilon//HCKIE

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-365a-5p
rs1166908611 chr16:14309308    T/C
rs1368596991 chr16:14309314    G/A
rs1380926089 chr16:14309318    A/G
rs1396179427 chr16:14309310    G/C
rs1428928383 chr16:14309320    G/A
rs773834113 chr16:14309301    G/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CSNK1E
chr22:38698594(-) A-I      intronic
chr22:38698568(-) A-I      intronic
chr22:38698544(-) A-I      intronic
chr22:38698553(-) A-I      intronic
chr22:38698592(-) A-I      intronic
chr22:38697627(-) A-I      intronic
chr22:38697520(-) A-I      intronic
chr22:38705654(-) A-I      intronic
chr22:38705536(-) A-I      intronic
chr22:38703869(-) A-I      intronic
chr22:38703068(-) A-I      intronic
chr22:38703048(-) A-I      intronic
chr22:38698629(-) A-I      intronic
chr22:38698607(-) A-I      intronic
chr22:38698604(-) A-I      intronic
chr22:38698567(-) A-I      intronic
chr22:38697578(-) A-I      intronic
chr22:38703113(-) A-I      intronic
chr22:38703435(-) A-I      intronic
chr22:38702481(-) A-I      intronic
chr22:38697490(-) A-I      intronic
chr22:38703405(-) A-I      intronic
chr22:38703093(-) A-I      intronic
chr22:38697605(-) A-I      intronic
chr22:38697612(-) A-I      intronic
chr22:38703825(-) A-I      intronic
chr22:38703100(-) A-I      intronic
chr22:38697614(-) A-I      intronic
chr22:38703004(-) A-I      intronic
chr22:38705542(-) A-I      intronic
chr22:38698664(-) A-I      intronic
chr22:38703967(-) A-I      intronic
chr22:38703028(-) A-I      intronic
chr22:38708232(-) A-I      intronic
chr22:38697632(-) A-I      intronic
chr22:38703839(-) A-I      intronic
chr22:38703990(-) A-I      intronic
chr22:38697712(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED CSNK1E
chr22:38687998(-) A-G intron -    22484847
chr22:38688131(-) A-G intron -    22484847
chr22:38693017(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CSNK1E
chr22:38686756-38686757(-) m6A 3'UTR       24981863//27773535//22608085
chr22:38686799-38686800(-) m6A 3'UTR       24981863//27773535//22608085
chr22:38686807-38686808(-) m6A 3'UTR       24981863//27773535//22608085
chr22:38686822-38686823(-) m6A 3'UTR       24981863//27773535//22608085
chr22:38687115-38687116(-) m6A 3'UTR       24284625
chr22:38687250-38687251(-) m6A 3'UTR       24284625
chr22:38687318-38687319(-) m6A 3'UTR       24284625//27773535
chr22:38687852-38687853(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27371828//22608085
chr22:38687864-38687865(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27371828//22608085
chr22:38687875-38687876(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27371828//22608085
chr22:38687888-38687889(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27371828//22608085
chr22:38687985-38687986(-) m6A 3'UTR//intron       24284625//27773535//22608085
chr22:38688240-38688241(-) m6A 3'UTR//intron       -
chr22:38688305-38688306(-) m6A 3'UTR//intron       -
chr22:38688321-38688322(-) m6A 3'UTR//intron       -
chr22:38688481-38688482(-) m6A 3'UTR//intron       -
chr22:38688516-38688517(-) m6A 3'UTR//intron       -
chr22:38688575-38688576(-) m6A 3'UTR//intron       -
chr22:38688593-38688594(-) m6A 3'UTR//intron       -
chr22:38690157-38690158(-) m6A 3'UTR//CDS//exon       -
chr22:38690495-38690496(-) m6A 3'UTR//CDS//exon       27773536//22575960
chr22:38690511-38690512(-) m6A 3'UTR//CDS//exon       22575960
chr22:38691396-38691397(-) m6A 3'UTR//intron       24284625//22575960
chr22:38692298-38692299(-) m6A 3'UTR//intron       24284625//25456834//24981863//27773535//22575960//22608085
chr22:38692434-38692435(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr22:38692439-38692440(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr22:38692484-38692485(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr22:38692497-38692498(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr22:38692535-38692536(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr22:38692725-38692726(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr22:38692766-38692767(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr22:38692796-38692797(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr22:38692876-38692877(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr22:38692955-38692956(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr22:38692972-38692973(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr22:38692995-38692996(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr22:38693090-38693091(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr22:38693156-38693157(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr22:38693624-38693625(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr22:38693633-38693634(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr22:38693639-38693640(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr22:38693664-38693665(-) m6A 3'UTR//intron       24284625//25456834//24981863//27773535//27371828//22575960//22608085
chr22:38693680-38693681(-) m6A 3'UTR//intron       24284625//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr22:38693742-38693743(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085
chr22:38693909-38693910(-) m6A 3'UTR//intron       24284625//25456834//24981863//27371828//22575960
chr22:38693929-38693930(-) m6A 3'UTR//intron       24284625//25456834//24981863//27371828//22575960
chr22:38694155-38694156(-) m6A 3'UTR//CDS//intron       24284625//22575960
chr22:38694671-38694672(-) m6A exon//intron       24284625//25456834//24981863//27371828//27773536//22575960//22608085
chr22:38694755-38694756(-) m6A exon//intron       24284625//25456834//24981863//27371828//27773536//22575960//22608085
chr22:38694803-38694804(-) m6A CDS//exon       24284625//27773535//22575960//22608085
chr22:38696778-38696779(-) m6A CDS//exon       24284625//27773535//22575960
chr22:38696784-38696785(-) m6A CDS//exon       24284625//27773535//22575960
chr22:38696925-38696926(-) m6A CDS//exon       24284625//27773535//22575960
chr22:38698929-38698930(-) m6A CDS//exon       24284625//27773535//22575960
chr22:38699199-38699200(-) m6A CDS       24284625//24209618//22575960
chr22:38710122-38710123(-) Am CDS       -
chr22:38710142-38710143(-) m6A CDS       24284625//24209618//22575960
chr22:38712728-38712729(-) m6A 5'UTR//intron       24284625//24209618//27371828
chr22:38712770-38712771(-) m6A 5'UTR//intron       -
chr22:38714028-38714029(-) m1A 5'UTR//intron       26863410
chr22:38732602-38732603(-) m6A intron       -
chr22:38732661-38732662(-) m6A 5'UTR       -
chr22:38740289-38740290(-) m6A intron       22608085
chr22:38740340-38740341(-) m6A intron       22608085
chr22:38740399-38740400(-) m6A intron       22608085
chr22:38746877-38746878(-) m6A intron       27773535
chr22:38746981-38746982(-) m6A intron       27773535
chr22:38747001-38747002(-) m6A intron       27773535
chr22:38756687-38756688(-) m6A intron       22608085
chr22:38756732-38756733(-) m6A intron       22608085
chr22:38776987-38776988(-) m6A 5'UTR       -
chr22:38777938-38777939(-) m6A intron       -
chr22:38794519-38794520(-) m6A 5'UTR       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-365a-5p
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
CSNK1E
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-365a-5p
Interactor2: CSNK1E

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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