Basic Information:

  VIRBase ID:  

HHID00014012

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365a-5p:  MIMAT0009199          ANGPT2:  NM_001386335     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-365a-5p	ANGPT2
miRBase Accession/Entrez ID	MIMAT0009199	285
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	AGPT2//ANG2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-365a-5p	rs1166908611 chr16:14309308    T/C rs1368596991 chr16:14309314    G/A rs1380926089 chr16:14309318    A/G rs1396179427 chr16:14309310    G/C rs1428928383 chr16:14309320    G/A rs773834113 chr16:14309301    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ANGPT2	chr8:6381248(-) A-I      intronic chr8:6381226(-) A-I      intronic chr8:6381285(-) A-I      intronic chr8:6364530(-) A-I      intronic chr8:6364526(-) A-I      intronic chr8:6381249(-) A-I      intronic chr8:6381242(-) A-I      intronic chr8:6371817(-) A-I      intronic chr8:6381288(-) A-I      intronic chr8:6371808(-) A-I      intronic chr8:6364506(-) A-I      intronic chr8:6381239(-) A-I      intronic chr8:6364502(-) A-I      intronic chr8:6379764(-) A-I      intronic chr8:6364515(-) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ANGPT2	chr8:6360078-6360079(-) m6A 3'UTR       - chr8:6360132-6360133(-) m6A 3'UTR       - chr8:6360152-6360153(-) m6A 3'UTR       - chr8:6360243-6360244(-) m6A 3'UTR       - chr8:6360276-6360277(-) m6A 3'UTR       27773535 chr8:6360281-6360282(-) m6A 3'UTR       27773535 chr8:6360353-6360354(-) m6A 3'UTR       27773535 chr8:6360372-6360373(-) m6A 3'UTR       27773535 chr8:6360390-6360391(-) m6A 3'UTR       27773535 chr8:6360395-6360396(-) m6A 3'UTR       27773535 chr8:6360415-6360416(-) m6A 3'UTR       27773535 chr8:6360422-6360423(-) m6A 3'UTR       27773535 chr8:6360433-6360434(-) m6A 3'UTR       27773535 chr8:6360451-6360452(-) m6A 3'UTR       27773535 chr8:6360465-6360466(-) m6A 3'UTR       - chr8:6360494-6360495(-) m6A 3'UTR       - chr8:6360576-6360577(-) m6A 3'UTR       - chr8:6360589-6360590(-) m6A 3'UTR       - chr8:6360599-6360600(-) m6A 3'UTR       - chr8:6360620-6360621(-) m6A 3'UTR       - chr8:6420189-6420190(-) m6A CDS       - chr8:6420201-6420202(-) m6A CDS       - chr8:6420303-6420304(-) m6A CDS       - chr8:6420375-6420376(-) m6A CDS       - chr8:6420514-6420515(-) m6A 5'UTR       25456834 chr8:6420566-6420567(-) m6A 5'UTR       25456834 chr8:6420580-6420581(-) m6A 5'UTR       25456834 chr8:6420615-6420616(-) m6A 5'UTR       25456834 chr8:6420629-6420630(-) m6A 5'UTR       25456834 chr8:6420677-6420678(-) m6A 5'UTR       25456834 chr8:6420728-6420729(-) m6A 5'UTR       - chr8:6420735-6420736(-) m6A 5'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-365a-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	ANGPT2	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-365a-5p
Interactor2: ANGPT2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).