Basic Information:

  VIRBase ID:  

HHID00014004

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365a-5p:  MIMAT0009199          ADPRH:  NM_001291949     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-365a-5p	ADPRH
miRBase Accession/Entrez ID	MIMAT0009199	141
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ARH1//hARH1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-365a-5p	rs1166908611 chr16:14309308    T/C rs1368596991 chr16:14309314    G/A rs1380926089 chr16:14309318    A/G rs1396179427 chr16:14309310    G/C rs1428928383 chr16:14309320    G/A rs773834113 chr16:14309301    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ADPRH	chr3:119303362(+) A-I      intronic chr3:119303299(+) A-I      intronic chr3:119303290(+) A-I      intronic chr3:119303274(+) A-I      intronic chr3:119303258(+) A-I      intronic chr3:119302774(+) A-I      intronic chr3:119302764(+) A-I      intronic chr3:119302724(+) A-I      intronic chr3:119302718(+) A-I      intronic chr3:119302705(+) A-I      intronic chr3:119301526(+) A-I      intronic chr3:119300070(+) A-I      intronic chr3:119301466(+) A-I      intronic chr3:119303263(+) A-I      intronic chr3:119303400(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ADPRH	chr3:119302024(+) T-C intron -    22484847 chr3:119302042(+) T-C intron -    22484847 chr3:119303263(+) A-G intron -    22484847 chr3:119303288(+) T-C intron -    22484847 chr3:119303328(+) T-C intron -    22484847 chr3:119304535(+) T-C intron -    22484847 chr3:119304561(+) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ADPRH	chr3:119298573-119298574(+) m6A 5'UTR//exon       24981863 chr3:119299165-119299166(+) m6A 5'UTR//intron       - chr3:119299218-119299219(+) m6A 5'UTR//intron       - chr3:119299471-119299472(+) m6A 5'UTR//intron       - chr3:119299476-119299477(+) m6A 5'UTR//intron       - chr3:119300980-119300981(+) m6A 5'UTR//intron       - chr3:119301012-119301013(+) m6A 5'UTR//intron       - chr3:119301281-119301282(+) m6A CDS//intron       - chr3:119301293-119301294(+) m6A CDS//intron       - chr3:119305278-119305279(+) m6A CDS//exon       - chr3:119305390-119305391(+) m6A CDS//exon       - chr3:119305414-119305415(+) m6A CDS//exon       - chr3:119306323-119306324(+) m6A CDS//exon       - chr3:119306346-119306347(+) m6A CDS//exon       - chr3:119306510-119306511(+) m6A CDS//exon       - chr3:119306555-119306556(+) m6A CDS//exon       - chr3:119306640-119306641(+) m6A CDS//exon       - chr3:119306654-119306655(+) m6A CDS//exon       - chr3:119308496-119308497(+) m6A 3'UTR       - chr3:119308585-119308586(+) m6A 3'UTR       - chr3:119308593-119308594(+) m6A 3'UTR       - chr3:119308609-119308610(+) m6A 3'UTR       - chr3:119308740-119308741(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-365a-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	ADPRH	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-365a-5p
Interactor2: ADPRH

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).