Basic Information:

  VIRBase ID:  

HHID00013907

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1305:  MIMAT0005893          NCR3LG1:  NM_001202439     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1305	NCR3LG1
miRBase Accession/Entrez ID	MIMAT0005893	374383
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	B7-H6//B7H6//DKFZp686O24166

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1305	rs1391055872 chr4:182169359    G/A rs1460502740 chr4:182169360    A/G rs190183451 chr4:182169358    G/A rs760149578 chr4:182169357    G/T rs774577022 chr4:182169356    T/C rs911409575 chr4:182169355    A/C rs911409575 chr4:182169355    A/G rs931724077 chr4:182169352    C/G rs971149992 chr4:182169361    G/A rs985999312 chr4:182169354    A/G rs1192955520 chr4:182169349    A/G rs1240810346 chr4:182169350    C/A rs1240810346 chr4:182169350    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	NCR3LG1	chr11:17376797(+) A-I      intronic chr11:17376758(+) A-I      intronic chr11:17377538(+) A-I      intronic chr11:17377486(+) A-I      intronic chr11:17377537(+) A-I      intronic chr11:17377457(+) A-I      intronic chr11:17389495(+) A-I      intronic chr11:17377444(+) A-I      intronic chr11:17377431(+) A-I      intronic chr11:17377412(+) A-I      intronic chr11:17377409(+) A-I      intronic chr11:17376766(+) A-I      intronic chr11:17377850(+) A-I      intronic chr11:17376864(+) A-I      intronic chr11:17376685(+) A-I      intronic chr11:17381715(+) A-I      intronic chr11:17377487(+) A-I      intronic chr11:17377370(+) A-I      intronic chr11:17376784(+) A-I      intronic chr11:17376762(+) A-I      intronic chr11:17377550(+) A-I      intronic chr11:17377401(+) A-I      intronic chr11:17377462(+) A-I      intronic chr11:17376782(+) A-I      intronic chr11:17376898(+) A-I      intronic chr11:17376914(+) A-I      intronic chr11:17377393(+) A-I      intronic chr11:17377548(+) A-I      intronic chr11:17377376(+) A-I      intronic chr11:17377891(+) A-I      intronic chr11:17377484(+) A-I      intronic chr11:17377569(+) A-I      intronic chr11:17376692(+) A-I      intronic chr11:17376765(+) A-I      intronic chr11:17376779(+) A-I      intronic chr11:17377531(+) A-I      intronic chr11:17390314(+) A-I      intronic chr11:17376741(+) A-I      intronic chr11:17376823(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	NCR3LG1	chr11:17398771(+) A-I intron -    21960545 chr11:17398814(+) A-I intron -    21960545 chr11:17377484(+) A-G intron -    22484847 chr11:17398771(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	NCR3LG1	chr11:17388795-17388796(+) m6A CDS       24284625 chr11:17388803-17388804(+) m6A CDS       24284625 chr11:17390415-17390416(+) m6A CDS       24284625 chr11:17390424-17390425(+) m6A CDS       24284625 chr11:17390474-17390475(+) m6A CDS       24284625//22608085 chr11:17393602-17393603(+) m6A CDS       24284625//24981863//22608085 chr11:17393610-17393611(+) m6A CDS       24284625//24981863//22608085 chr11:17393627-17393628(+) m6A CDS       24284625//24981863//22608085 chr11:17393914-17393915(+) m6A CDS       24284625 chr11:17393929-17393930(+) m6A CDS       24284625 chr11:17393983-17393984(+) m6A CDS       24284625 chr11:17394070-17394071(+) m6A 3'UTR       24284625 chr11:17394111-17394112(+) m6A 3'UTR       24284625 chr11:17394132-17394133(+) m6A 3'UTR       24284625 chr11:17394182-17394183(+) m6A 3'UTR       24284625 chr11:17394847-17394848(+) m6A 3'UTR       24284625 chr11:17394894-17394895(+) m6A 3'UTR       24284625 chr11:17394914-17394915(+) m6A 3'UTR       24284625 chr11:17395242-17395243(+) m6A 3'UTR       - chr11:17395288-17395289(+) m6A 3'UTR       - chr11:17395394-17395395(+) m6A 3'UTR       - chr11:17397233-17397234(+) m6A 3'UTR       24981863 chr11:17397280-17397281(+) m6A 3'UTR       24981863 chr11:17397292-17397293(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1305	Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	NCR3LG1	Exosome Blood     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HeLa-S3 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-1305	Panobinostat       6918837 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Paclitaxel       36314 Sorafenib       216239 5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120 Dovitinib       135398510 Crizotinib       11626560

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1305
Interactor2: NCR3LG1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).