Basic Information:

  VIRBase ID:  

HHID00013871

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1305:  MIMAT0005893          CHAMP1:  NM_001164145     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1305	CHAMP1
miRBase Accession/Entrez ID	MIMAT0005893	283489
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	C13orf8//CAMP//CHAMP//MRD40//ZNF828

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1305	rs1391055872 chr4:182169359    G/A rs1460502740 chr4:182169360    A/G rs190183451 chr4:182169358    G/A rs760149578 chr4:182169357    G/T rs774577022 chr4:182169356    T/C rs911409575 chr4:182169355    A/C rs911409575 chr4:182169355    A/G rs931724077 chr4:182169352    C/G rs971149992 chr4:182169361    G/A rs985999312 chr4:182169354    A/G rs1192955520 chr4:182169349    A/G rs1240810346 chr4:182169350    C/A rs1240810346 chr4:182169350    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CHAMP1	chr13:115082968(+) A-I      intronic chr13:115082958(+) A-I      intronic chr13:115082618(+) A-I      intronic chr13:115082915(+) A-I      intronic chr13:115082846(+) A-I      intronic chr13:115082839(+) A-I      intronic chr13:115082774(+) A-I      intronic chr13:115082682(+) A-I      intronic chr13:115082676(+) A-I      intronic chr13:115082659(+) A-I      intronic chr13:115082658(+) A-I      intronic chr13:115082654(+) A-I      intronic chr13:115082622(+) A-I      intronic chr13:115082610(+) A-I      intronic chr13:115082597(+) A-I      intronic chr13:115082593(+) A-I      intronic chr13:115082592(+) A-I      intronic chr13:115082548(+) A-I      intronic chr13:115082851(+) A-I      intronic chr13:115082525(+) A-I      intronic chr13:115082867(+) A-I      intronic chr13:115081412(+) A-I      intronic chr13:115083044(+) A-I      intronic chr13:115082988(+) A-I      intronic chr13:115082984(+) A-I      intronic chr13:115083111(+) A-I      intronic chr13:115082976(+) A-I      intronic chr13:115083024(+) A-I      intronic chr13:115082045(+) A-I      intronic chr13:115082949(+) A-I      intronic chr13:115081669(+) A-I      intronic chr13:115082894(+) A-I      intronic chr13:115082899(+) A-I      intronic chr13:115081739(+) A-I      intronic chr13:115087774(+) A-I      intronic chr13:115082634(+) A-I      intronic chr13:115082992(+) A-I      intronic chr13:115082693(+) A-I      intronic chr13:115083106(+) A-I      intronic chr13:115083877(+) A-I      intronic chr13:115082762(+) A-I      intronic chr13:115082956(+) A-I      intronic chr13:115082573(+) A-I      intronic chr13:115082845(+) A-I      intronic chr13:115081386(+) A-I      intronic chr13:115082919(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CHAMP1	chr13:115089309-115089310(+) m6A 5'UTR       24284625//25456834//24981863//22575960//22608085 chr13:115089334-115089335(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr13:115089343-115089344(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr13:115089390-115089391(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr13:115089568-115089569(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr13:115089582-115089583(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr13:115089598-115089599(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr13:115089615-115089616(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr13:115089623-115089624(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr13:115089655-115089656(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr13:115089685-115089686(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr13:115089716-115089717(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr13:115089724-115089725(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr13:115089757-115089758(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr13:115089790-115089791(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr13:115089821-115089822(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr13:115089850-115089851(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr13:115089874-115089875(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr13:115089910-115089911(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr13:115089934-115089935(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr13:115089943-115089944(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr13:115089994-115089995(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr13:115090022-115090023(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr13:115090081-115090082(+) m6A CDS       24284625//24209618//25456834//24981863//22575960 chr13:115090090-115090091(+) m6A CDS       24284625//24209618//25456834//24981863//22575960 chr13:115090133-115090134(+) m6A CDS       24284625//24209618//25456834//24981863//22575960 chr13:115090180-115090181(+) m6A CDS       24284625//24209618//25456834//24981863//22575960 chr13:115090222-115090223(+) m6A CDS       24284625//24209618//25456834//22575960 chr13:115090255-115090256(+) m6A CDS       24284625//24209618//25456834//22575960 chr13:115090312-115090313(+) m6A CDS       24284625//24209618//25456834//24981863//22575960 chr13:115090330-115090331(+) m6A CDS       24284625//24209618//25456834//24981863//22575960 chr13:115090354-115090355(+) m6A CDS       24284625//24209618//25456834//24981863//22575960 chr13:115090363-115090364(+) m6A CDS       24284625//24209618//25456834//24981863//22575960 chr13:115090387-115090388(+) m6A CDS       24284625//24209618//25456834//24981863//22575960 chr13:115090396-115090397(+) m6A CDS       24284625//24209618//25456834//24981863//22575960 chr13:115090504-115090505(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr13:115090514-115090515(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr13:115090537-115090538(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr13:115090579-115090580(+) m6A CDS       24284625//24209618//25456834//24981863//22575960 chr13:115090639-115090640(+) m6A CDS       24284625 chr13:115090688-115090689(+) m6A CDS       24284625 chr13:115090786-115090787(+) m6A CDS       24284625//24981863 chr13:115090802-115090803(+) m6A CDS       24284625//24209618//24981863//22575960 chr13:115090810-115090811(+) m6A CDS       24284625//24209618//24981863//22575960 chr13:115090897-115090898(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr13:115090925-115090926(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr13:115091002-115091003(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr13:115091059-115091060(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr13:115091113-115091114(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr13:115091134-115091135(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr13:115091181-115091182(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr13:115091231-115091232(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr13:115091322-115091323(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr13:115091331-115091332(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr13:115091662-115091663(+) m6A CDS       24981863//26404942//22608085 chr13:115091728-115091729(+) m6A CDS       24981863//26404942//22608085 chr13:115091798-115091799(+) m6A 3'UTR       22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1305	Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	CHAMP1	Exosome Blood     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-1305	Panobinostat       6918837 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Paclitaxel       36314 Sorafenib       216239 5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120 Dovitinib       135398510 Crizotinib       11626560

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1305
Interactor2: CHAMP1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).