Detail Information

Basic Information:


  VIRBase ID:  

HHID00013807

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1305:           TMEM161B:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-1305 TMEM161B
miRBase
Accession/Entrez ID		 MIMAT0005893 153396
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - FLB3342//PRO1313

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-1305
rs1391055872 chr4:182169359    G/A
rs1460502740 chr4:182169360    A/G
rs190183451 chr4:182169358    G/A
rs760149578 chr4:182169357    G/T
rs774577022 chr4:182169356    T/C
rs911409575 chr4:182169355    A/C
rs911409575 chr4:182169355    A/G
rs931724077 chr4:182169352    C/G
rs971149992 chr4:182169361    G/A
rs985999312 chr4:182169354    A/G
rs1192955520 chr4:182169349    A/G
rs1240810346 chr4:182169350    C/A
rs1240810346 chr4:182169350    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TMEM161B
chr5:87525678(-) A-I      intronic
chr5:87525658(-) A-I      intronic
chr5:87517234(-) A-I      intronic
chr5:87507510(-) A-I      intronic
chr5:87517264(-) A-I      intronic
chr5:87517954(-) A-I      intronic
chr5:87525740(-) A-I      intronic
chr5:87530671(-) A-I      intronic
chr5:87517153(-) A-I      intronic
chr5:87517240(-) A-I      intronic
chr5:87518024(-) A-I      intronic
chr5:87528664(-) A-I      intronic
chr5:87522897(-) A-I      intronic
chr5:87517181(-) A-I      intronic
chr5:87525684(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TMEM161B
chr5:87517240(-) A-G intron -    22484847
chr5:87517264(-) A-G intron -    22484847
chr5:87525684(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TMEM161B
chr5:87485541-87485542(-) m6A 3'UTR       27773535
chr5:87491557-87491558(-) Y 3'UTR//intron       26075521
chr5:87491917-87491918(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr5:87491951-87491952(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr5:87492079-87492080(-) Y 3'UTR//CDS//intron       26075521
chr5:87492120-87492121(-) m6A 3'UTR//CDS//intron       24284625//24981863//27773535//22608085
chr5:87564589-87564590(-) m6A 5'UTR//exon//intron       24981863
chr5:87564611-87564612(-) m6A 5'UTR//exon       24981863
chr5:87564650-87564651(-) m6A 5'UTR//exon       24981863
chr5:87564693-87564694(-) m6A exon       25456834//24981863
chr5:87565183-87565184(-) m6A exon       24284625//24981863//22608085
chr5:87565200-87565201(-) m6A exon       24284625//24981863//22608085
chr5:87565266-87565267(-) m6A exon       24284625

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-1305
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
TMEM161B
Chromatin K562 cells     -
Cytosol K562 cells     -
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-1305
Panobinostat       6918837
Irinotecan       60838
Topotecan       60700
l-685,458       5479543
Palbociclib       5330286
Paclitaxel       36314
Sorafenib       216239
5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120
Dovitinib       135398510
Crizotinib       11626560

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-1305
Interactor2: TMEM161B

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

Starting a new search, please wait ...