Basic Information:

  VIRBase ID:  

HHID00013774

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1305:  MIMAT0005893          APOBEC3D:  NM_152426     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1305	APOBEC3D
miRBase Accession/Entrez ID	MIMAT0005893	140564
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	A3D//A3DE//APOBEC3DE//APOBEC3E//ARP6

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1305	rs1391055872 chr4:182169359    G/A rs1460502740 chr4:182169360    A/G rs190183451 chr4:182169358    G/A rs760149578 chr4:182169357    G/T rs774577022 chr4:182169356    T/C rs911409575 chr4:182169355    A/C rs911409575 chr4:182169355    A/G rs931724077 chr4:182169352    C/G rs971149992 chr4:182169361    G/A rs985999312 chr4:182169354    A/G rs1192955520 chr4:182169349    A/G rs1240810346 chr4:182169350    C/A rs1240810346 chr4:182169350    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	APOBEC3D	chr22:39427060(+) A-I      intronic chr22:39422886(+) A-I      intronic chr22:39429095(+) A-I      3'UTR chr22:39422857(+) A-I      intronic chr22:39422882(+) A-I      intronic chr22:39422922(+) A-I      intronic chr22:39422936(+) A-I      intronic chr22:39424686(+) A-I      intronic chr22:39424789(+) A-I      intronic chr22:39424842(+) A-I      intronic chr22:39424862(+) A-I      intronic chr22:39424868(+) A-I      intronic chr22:39425720(+) A-I      intronic chr22:39425683(+) A-I      intronic chr22:39425788(+) A-I      intronic chr22:39426985(+) A-I      intronic chr22:39426995(+) A-I      intronic chr22:39427073(+) A-I      intronic chr22:39427106(+) A-I      intronic chr22:39428673(+) A-I      3'UTR chr22:39428985(+) A-I      3'UTR chr22:39428907(+) A-I      3'UTR chr22:39428903(+) A-I      3'UTR chr22:39428698(+) A-I      3'UTR chr22:39429073(+) A-I      3'UTR chr22:39429070(+) A-I      3'UTR chr22:39429039(+) A-I      3'UTR chr22:39429107(+) A-I      3'UTR chr22:39429168(+) A-I      3'UTR chr22:39428680(+) A-I      3'UTR chr22:39428734(+) A-I      3'UTR chr22:39429047(+) A-I      3'UTR chr22:39429010(+) A-I      3'UTR chr22:39422801(+) A-I      intronic chr22:39427465(+) A-I      intronic chr22:39422860(+) A-I      intronic chr22:39427364(+) A-I      intronic chr22:39427028(+) A-I      intronic chr22:39422781(+) A-I      intronic chr22:39424763(+) A-I      intronic chr22:39424865(+) A-I      intronic chr22:39424753(+) A-I      intronic chr22:39427078(+) A-I      intronic chr22:39422874(+) A-I      intronic chr22:39422939(+) A-I      intronic chr22:39427428(+) A-I      intronic chr22:39429065(+) A-I      3'UTR chr22:39428829(+) A-I      3'UTR chr22:39429011(+) A-I      3'UTR chr22:39428679(+) A-I      3'UTR chr22:39428737(+) A-I      3'UTR chr22:39429072(+) A-I      3'UTR chr22:39428739(+) A-I      3'UTR chr22:39429063(+) A-I      3'UTR chr22:39417252(+) A-I      5'UTR chr22:39428655(+) A-I      3'UTR chr22:39429142(+) A-I      3'UTR chr22:39429150(+) A-I      3'UTR chr22:39428647(+) A-I      3'UTR chr22:39417242(+) A-I      5'UTR chr22:39429198(+) A-I      3'UTR chr22:39429101(+) A-I      3'UTR chr22:39429079(+) A-I      3'UTR chr22:39429111(+) A-I      3'UTR chr22:39428699(+) A-I      3'UTR chr22:39428727(+) A-I      3'UTR chr22:39422898(+) A-I      intronic chr22:39426980(+) A-I      intronic chr22:39422930(+) A-I      intronic chr22:39424628(+) A-I      intronic chr22:39425796(+) A-I      intronic chr22:39422861(+) A-I      intronic chr22:39424879(+) A-I      intronic chr22:39425703(+) A-I      intronic chr22:39424829(+) A-I      intronic chr22:39427034(+) A-I      intronic chr22:39427024(+) A-I      intronic chr22:39427050(+) A-I      intronic chr22:39424793(+) A-I      intronic chr22:39427454(+) A-I      intronic chr22:39424783(+) A-I      intronic chr22:39426923(+) A-I      intronic chr22:39422921(+) A-I      intronic chr22:39424819(+) A-I      intronic chr22:39422838(+) A-I      intronic chr22:39425760(+) A-I      intronic chr22:39426924(+) A-I      intronic chr22:39426904(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	APOBEC3D	chr22:39428727(+) A-I exon 3'UTR    15258596   //22327324 chr22:39428737(+) A-I exon 3'UTR    15258596 chr22:39428739(+) A-I exon 3'UTR    15258596 chr22:39428854(+) A-I exon 3'UTR    15258596   //22327324 chr22:39422861(+) A-I intron -    22327324 chr22:39422883(+) A-I intron -    22327324 chr22:39424628(+) A-I intron -    22327324 chr22:39424819(+) A-I intron -    22327324 chr22:39424865(+) A-I intron -    22327324 chr22:39426868(+) A-I intron -    22327324 chr22:39426980(+) A-I intron -    22327324 chr22:39428716(+) A-I intron -    22327324 chr22:39429068(+) A-I intron -    21960545   //22327324 chr22:39429101(+) A-I intron -    22327324 chr22:39429125(+) A-I intron -    22327324 chr22:39429150(+) A-I intron -    22327324 chr22:39429166(+) A-I intron -    22327324 chr22:39428727(+) A-G intron -    21725310   //22484847 chr22:39428854(+) A-G intron -    21725310   //22484847 chr22:39422861(+) A-G intron -    22484847 chr22:39422882(+) A-T intron -    22484847 chr22:39422883(+) A-G intron -    22484847 chr22:39422896(+) A-G intron -    22484847 chr22:39422921(+) A-G intron -    22484847 chr22:39422930(+) A-G intron -    22484847 chr22:39422939(+) A-G intron -    22484847 chr22:39424628(+) A-G intron -    22484847 chr22:39424753(+) A-G intron -    22484847 chr22:39424763(+) A-G intron -    22484847 chr22:39424783(+) A-G intron -    22484847 chr22:39424793(+) A-G intron -    22484847 chr22:39424819(+) A-G intron -    22484847 chr22:39424865(+) A-G intron -    22484847 chr22:39424875(+) A-G intron -    22484847 chr22:39424879(+) A-G intron -    22484847 chr22:39425742(+) A-G intron -    22484847 chr22:39425760(+) A-G intron -    22484847 chr22:39425799(+) A-G intron -    22484847 chr22:39425825(+) A-G intron -    22484847 chr22:39425884(+) A-G intron -    22484847 chr22:39426980(+) A-G intron -    22484847 chr22:39427024(+) A-G intron -    22484847 chr22:39427028(+) A-G intron -    22484847 chr22:39427051(+) A-G intron -    22484847 chr22:39427078(+) A-G intron -    22484847 chr22:39427454(+) A-G intron -    22484847 chr22:39428716(+) A-G intron -    22484847 chr22:39429065(+) A-G intron -    22484847 chr22:39429068(+) A-G intron -    22484847 chr22:39429069(+) A-G intron -    22484847 chr22:39429079(+) A-G intron -    22484847 chr22:39429101(+) A-G intron -    22484847 chr22:39429125(+) A-G intron -    22484847 chr22:39429150(+) A-G intron -    22484847 chr22:39429166(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	APOBEC3D	chr22:39411601-39411602(+) m6A intron       24284625//24209618//24981863//26404942//22575960//22608085 chr22:39411649-39411650(+) m6A intron       24284625//24981863//26404942//22575960//22608085 chr22:39414467-39414468(+) m6A intron       24284625 chr22:39414565-39414566(+) m6A intron       24284625//25456834//24981863 chr22:39414620-39414621(+) m6A intron       24284625//25456834//24981863 chr22:39414692-39414693(+) m6A intron       24284625//24981863 chr22:39414787-39414788(+) m6A intron       24981863 chr22:39414942-39414943(+) m6A intron       25456834//24981863 chr22:39414961-39414962(+) m6A intron       25456834//24981863 chr22:39414986-39414987(+) m6A intron       25456834//24981863 chr22:39415015-39415016(+) m6A intron       24981863 chr22:39415026-39415027(+) m6A intron       24981863 chr22:39415053-39415054(+) m6A intron       24981863 chr22:39415070-39415071(+) m6A intron       25456834//24981863 chr22:39415127-39415128(+) m6A intron       25456834//24981863//22608085 chr22:39415188-39415189(+) m6A intron       24284625//25456834//24981863//22608085 chr22:39415214-39415215(+) m6A intron       24284625//25456834//24981863//22608085 chr22:39415234-39415235(+) m6A intron       24284625//25456834//24981863//22608085 chr22:39415280-39415281(+) m6A intron       24284625//24981863//22608085 chr22:39415315-39415316(+) m6A intron       24284625//24981863//22608085 chr22:39415370-39415371(+) m6A intron       24981863 chr22:39429133-39429134(+) m6A 3'UTR       25456834 chr22:39429167-39429168(+) m6A 3'UTR       25456834 chr22:39429186-39429187(+) m6A 3'UTR       25456834 chr22:39429211-39429212(+) m6A 3'UTR       25456834

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1305	Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	APOBEC3D	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Exosome Blood     - Nucleus Nasopharyngeal carcinoma cells     20498841

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-1305	Panobinostat       6918837 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Paclitaxel       36314 Sorafenib       216239 5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120 Dovitinib       135398510 Crizotinib       11626560

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1305
Interactor2: APOBEC3D

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).