Basic Information:

  VIRBase ID:  

HHID00013771

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1305:  MIMAT0005893          UBXN2B:  NR_156456     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1305	UBXN2B
miRBase Accession/Entrez ID	MIMAT0005893	137886
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	p37

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1305	rs1391055872 chr4:182169359    G/A rs1460502740 chr4:182169360    A/G rs190183451 chr4:182169358    G/A rs760149578 chr4:182169357    G/T rs774577022 chr4:182169356    T/C rs911409575 chr4:182169355    A/C rs911409575 chr4:182169355    A/G rs931724077 chr4:182169352    C/G rs971149992 chr4:182169361    G/A rs985999312 chr4:182169354    A/G rs1192955520 chr4:182169349    A/G rs1240810346 chr4:182169350    C/A rs1240810346 chr4:182169350    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	UBXN2B	chr8:59345203(+) A-I      intronic chr8:59337741(+) A-I      intronic chr8:59337699(+) A-I      intronic chr8:59338892(+) A-I      intronic chr8:59339908(+) A-I      intronic chr8:59339936(+) A-I      intronic chr8:59339948(+) A-I      intronic chr8:59343779(+) A-I      intronic chr8:59343787(+) A-I      intronic chr8:59356088(+) A-I      intronic chr8:59345172(+) A-I      intronic chr8:59337690(+) A-I      intronic chr8:59345202(+) A-I      intronic chr8:59332238(+) A-I      intronic chr8:59345215(+) A-I      intronic chr8:59346237(+) A-I      intronic chr8:59346240(+) A-I      intronic chr8:59337670(+) A-I      intronic chr8:59338883(+) A-I      intronic chr8:59356096(+) A-I      intronic chr8:59356102(+) A-I      intronic chr8:59356113(+) A-I      intronic chr8:59337664(+) A-I      intronic chr8:59338827(+) A-I      intronic chr8:59332228(+) A-I      intronic chr8:59338870(+) A-I      intronic chr8:59360807(+) A-I      3'UTR chr8:59360789(+) A-I      3'UTR chr8:59360797(+) A-I      3'UTR chr8:59360826(+) A-I      3'UTR chr8:59339827(+) A-I      intronic chr8:59346313(+) A-I      intronic chr8:59339859(+) A-I      intronic chr8:59339901(+) A-I      intronic chr8:59356090(+) A-I      intronic chr8:59346152(+) A-I      intronic chr8:59339029(+) A-I      intronic chr8:59343788(+) A-I      intronic chr8:59339764(+) A-I      intronic chr8:59353833(+) A-I      intronic chr8:59353762(+) A-I      intronic chr8:59359497(+) A-I      intronic chr8:59339880(+) A-I      intronic chr8:59330677(+) A-I      intronic chr8:59330787(+) A-I      intronic chr8:59343830(+) A-I      intronic chr8:59343811(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	UBXN2B	chr8:59339764(+) A-G intron -    22484847 chr8:59343788(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	UBXN2B	chr8:59325878-59325879(+) m6A exon//intron       24209618//25456834//24981863 chr8:59325890-59325891(+) m6A exon//intron       24209618//24981863 chr8:59325898-59325899(+) m6A exon//intron       24209618//24981863 chr8:59329467-59329468(+) m6A CDS//exon       24981863 chr8:59360168-59360169(+) m6A 3'UTR       24284625//24981863//22608085 chr8:59360188-59360189(+) m6A 3'UTR       24284625//24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1305	Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	UBXN2B	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome-free cytosol Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-1305	Panobinostat       6918837 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Paclitaxel       36314 Sorafenib       216239 5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120 Dovitinib       135398510 Crizotinib       11626560

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1305
Interactor2: UBXN2B

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).