Basic Information:

  VIRBase ID:  

HHID00013736

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1305:  MIMAT0005893          WDR17:  NM_170710     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1305	WDR17
miRBase Accession/Entrez ID	MIMAT0005893	116966
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1305	rs1391055872 chr4:182169359    G/A rs1460502740 chr4:182169360    A/G rs190183451 chr4:182169358    G/A rs760149578 chr4:182169357    G/T rs774577022 chr4:182169356    T/C rs911409575 chr4:182169355    A/C rs911409575 chr4:182169355    A/G rs931724077 chr4:182169352    C/G rs971149992 chr4:182169361    G/A rs985999312 chr4:182169354    A/G rs1192955520 chr4:182169349    A/G rs1240810346 chr4:182169350    C/A rs1240810346 chr4:182169350    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	WDR17	chr4:177067459(+) A-I      intronic chr4:177067436(+) A-I      intronic chr4:177067410(+) A-I      intronic chr4:176992674(+) A-I      intronic chr4:176992713(+) A-I      intronic chr4:177029989(+) A-I      intronic chr4:177073265(+) A-I      intronic chr4:177073271(+) A-I      intronic chr4:176989495(+) A-I      ncRNA chr4:177064538(+) A-I      intronic chr4:176997028(+) A-I      intronic chr4:177076796(+) A-I      intronic chr4:177064775(+) A-I      intronic chr4:176989593(+) A-I      intronic chr4:176997036(+) A-I      intronic chr4:176989575(+) A-I      intronic chr4:177064774(+) A-I      intronic chr4:177073343(+) A-I      intronic chr4:177064587(+) A-I      intronic chr4:177064633(+) A-I      intronic chr4:177064131(+) A-I      intronic chr4:177064087(+) A-I      intronic chr4:177064135(+) A-I      intronic chr4:177064812(+) A-I      intronic chr4:177064732(+) A-I      intronic chr4:176997102(+) A-I      intronic chr4:177074073(+) A-I      intronic chr4:177064079(+) A-I      intronic chr4:177073544(+) A-I      intronic chr4:177073347(+) A-I      intronic chr4:176996983(+) A-I      intronic chr4:177009554(+) A-I      intronic chr4:176992639(+) A-I      intronic chr4:177076765(+) A-I      intronic chr4:177091567(+) A-I      intronic chr4:177064755(+) A-I      intronic chr4:177064577(+) A-I      intronic chr4:177073464(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	WDR17	chr4:177100938-177100939(+) m6A 3'UTR       24981863 chr4:177100968-177100969(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1305	Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	WDR17	Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-1305	Panobinostat       6918837 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Paclitaxel       36314 Sorafenib       216239 5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120 Dovitinib       135398510 Crizotinib       11626560

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1305
Interactor2: WDR17

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).