Basic Information:

  VIRBase ID:  

HHID00013728

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1305:  MIMAT0005893          FCHO2:  NM_138782     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1305	FCHO2
miRBase Accession/Entrez ID	MIMAT0005893	115548
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1305	rs1391055872 chr4:182169359    G/A rs1460502740 chr4:182169360    A/G rs190183451 chr4:182169358    G/A rs760149578 chr4:182169357    G/T rs774577022 chr4:182169356    T/C rs911409575 chr4:182169355    A/C rs911409575 chr4:182169355    A/G rs931724077 chr4:182169352    C/G rs971149992 chr4:182169361    G/A rs985999312 chr4:182169354    A/G rs1192955520 chr4:182169349    A/G rs1240810346 chr4:182169350    C/A rs1240810346 chr4:182169350    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	FCHO2	chr5:72310742(+) A-I      intronic chr5:72310728(+) A-I      intronic chr5:72310677(+) A-I      intronic chr5:72310172(+) A-I      intronic chr5:72310147(+) A-I      intronic chr5:72309642(+) A-I      intronic chr5:72309614(+) A-I      intronic chr5:72308335(+) A-I      intronic chr5:72308325(+) A-I      intronic chr5:72308299(+) A-I      intronic chr5:72308284(+) A-I      intronic chr5:72306606(+) A-I      intronic chr5:72306557(+) A-I      intronic chr5:72306542(+) A-I      intronic chr5:72299832(+) A-I      intronic chr5:72297669(+) A-I      intronic chr5:72297667(+) A-I      intronic chr5:72379599(+) A-I      intronic chr5:72297233(+) A-I      intronic chr5:72296361(+) A-I      intronic chr5:72294683(+) A-I      intronic chr5:72292030(+) A-I      intronic chr5:72292019(+) A-I      intronic chr5:72291985(+) A-I      intronic chr5:72291249(+) A-I      intronic chr5:72291131(+) A-I      intronic chr5:72291122(+) A-I      intronic chr5:72283331(+) A-I      intronic chr5:72283310(+) A-I      intronic chr5:72283304(+) A-I      intronic chr5:72283189(+) A-I      intronic chr5:72283187(+) A-I      intronic chr5:72262934(+) A-I      intronic chr5:72259509(+) A-I      intronic chr5:72255736(+) A-I      intronic chr5:72255732(+) A-I      intronic chr5:72255719(+) A-I      intronic chr5:72255079(+) A-I      intronic chr5:72306503(+) A-I      intronic chr5:72306528(+) A-I      intronic chr5:72310291(+) A-I      intronic chr5:72310297(+) A-I      intronic chr5:72310326(+) A-I      intronic chr5:72310337(+) A-I      intronic chr5:72319327(+) A-I      intronic chr5:72319339(+) A-I      intronic chr5:72319342(+) A-I      intronic chr5:72319345(+) A-I      intronic chr5:72319347(+) A-I      intronic chr5:72319358(+) A-I      intronic chr5:72319369(+) A-I      intronic chr5:72319376(+) A-I      intronic chr5:72323769(+) A-I      intronic chr5:72323770(+) A-I      intronic chr5:72323775(+) A-I      intronic chr5:72323791(+) A-I      intronic chr5:72381082(+) A-I      intronic chr5:72381088(+) A-I      intronic chr5:72381096(+) A-I      intronic chr5:72380923(+) A-I      intronic chr5:72380345(+) A-I      intronic chr5:72306477(+) A-I      intronic chr5:72299725(+) A-I      intronic chr5:72299719(+) A-I      intronic chr5:72299716(+) A-I      intronic chr5:72299713(+) A-I      intronic chr5:72299710(+) A-I      intronic chr5:72263064(+) A-I      intronic chr5:72263063(+) A-I      intronic chr5:72263057(+) A-I      intronic chr5:72263025(+) A-I      intronic chr5:72263021(+) A-I      intronic chr5:72263006(+) A-I      intronic chr5:72263002(+) A-I      intronic chr5:72381017(+) A-I      intronic chr5:72381018(+) A-I      intronic chr5:72292020(+) A-I      intronic chr5:72381874(+) A-I      intronic chr5:72323911(+) A-I      intronic chr5:72323895(+) A-I      intronic chr5:72379648(+) A-I      intronic chr5:72379639(+) A-I      intronic chr5:72379634(+) A-I      intronic chr5:72379622(+) A-I      intronic chr5:72379612(+) A-I      intronic chr5:72379598(+) A-I      intronic chr5:72379518(+) A-I      intronic chr5:72379517(+) A-I      intronic chr5:72375027(+) A-I      intronic chr5:72374985(+) A-I      intronic chr5:72373410(+) A-I      intronic chr5:72367933(+) A-I      intronic chr5:72344910(+) A-I      intronic chr5:72344095(+) A-I      intronic chr5:72344093(+) A-I      intronic chr5:72344021(+) A-I      intronic chr5:72343665(+) A-I      intronic chr5:72332224(+) A-I      intronic chr5:72331391(+) A-I      intronic chr5:72331383(+) A-I      intronic chr5:72331361(+) A-I      intronic chr5:72306490(+) A-I      intronic chr5:72323819(+) A-I      intronic chr5:72310257(+) A-I      intronic chr5:72323763(+) A-I      intronic chr5:72323761(+) A-I      intronic chr5:72320471(+) A-I      intronic chr5:72320431(+) A-I      intronic chr5:72319290(+) A-I      intronic chr5:72312094(+) A-I      intronic chr5:72310823(+) A-I      intronic chr5:72310809(+) A-I      intronic chr5:72310738(+) A-I      intronic chr5:72310757(+) A-I      intronic chr5:72381072(+) A-I      intronic chr5:72306448(+) A-I      intronic chr5:72331551(+) A-I      intronic chr5:72295852(+) A-I      intronic chr5:72319416(+) A-I      intronic chr5:72321427(+) A-I      intronic chr5:72380967(+) A-I      intronic chr5:72311229(+) A-I      intronic chr5:72378840(+) A-I      intronic chr5:72354037(+) A-I      intronic chr5:72297146(+) A-I      intronic chr5:72330989(+) A-I      intronic chr5:72291222(+) A-I      intronic chr5:72319273(+) A-I      intronic chr5:72381055(+) A-I      intronic chr5:72375026(+) A-I      intronic chr5:72299754(+) A-I      intronic chr5:72344216(+) A-I      intronic chr5:72298961(+) A-I      intronic chr5:72299795(+) A-I      intronic chr5:72319265(+) A-I      intronic chr5:72381065(+) A-I      intronic chr5:72310261(+) A-I      intronic chr5:72308315(+) A-I      intronic chr5:72296080(+) A-I      intronic chr5:72297003(+) A-I      intronic chr5:72344183(+) A-I      intronic chr5:72281172(+) A-I      intronic chr5:72335634(+) A-I      intronic chr5:72306479(+) A-I      intronic chr5:72284154(+) A-I      intronic chr5:72379445(+) A-I      intronic chr5:72263022(+) A-I      intronic chr5:72310788(+) A-I      intronic chr5:72343943(+) A-I      intronic chr5:72299755(+) A-I      intronic chr5:72367956(+) A-I      intronic chr5:72335624(+) A-I      intronic chr5:72297179(+) A-I      intronic chr5:72306526(+) A-I      intronic chr5:72347567(+) A-I      intronic chr5:72381899(+) A-I      intronic chr5:72255078(+) A-I      intronic chr5:72380154(+) A-I      intronic chr5:72296175(+) A-I      intronic chr5:72367959(+) A-I      intronic chr5:72310362(+) A-I      intronic chr5:72297152(+) A-I      intronic chr5:72381411(+) A-I      intronic chr5:72284144(+) A-I      intronic chr5:72373457(+) A-I      intronic chr5:72344169(+) A-I      intronic chr5:72306561(+) A-I      intronic chr5:72323783(+) A-I      intronic chr5:72306527(+) A-I      intronic chr5:72291141(+) A-I      intronic chr5:72294059(+) A-I      intronic chr5:72284850(+) A-I      intronic chr5:72323870(+) A-I      intronic chr5:72306581(+) A-I      intronic chr5:72335690(+) A-I      intronic chr5:72373428(+) A-I      intronic chr5:72280646(+) A-I      intronic chr5:72299615(+) A-I      intronic chr5:72323844(+) A-I      intronic chr5:72310727(+) A-I      intronic chr5:72297643(+) A-I      intronic chr5:72310787(+) A-I      intronic chr5:72284956(+) A-I      intronic chr5:72306632(+) A-I      intronic chr5:72309581(+) A-I      intronic chr5:72331565(+) A-I      intronic chr5:72284854(+) A-I      intronic chr5:72306584(+) A-I      intronic chr5:72381552(+) A-I      intronic chr5:72381547(+) A-I      intronic chr5:72284778(+) A-I      intronic chr5:72308186(+) A-I      intronic chr5:72381121(+) A-I      intronic chr5:72344267(+) A-I      intronic chr5:72291187(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	FCHO2	chr5:72293198(+) A-I intron -    22327324 chr5:72293209(+) A-I intron -    22327324 chr5:72292453(+) A-I intron -    21960545 chr5:72295854(+) A-I intron -    21960545 chr5:72284144(+) A-G intron -    22484847 chr5:72284154(+) A-G intron -    22484847 chr5:72291200(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	FCHO2	chr5:72251823-72251824(+) m1A 5'UTR       26863196//26863410 chr5:72251902-72251903(+) m6A 5'UTR       24981863 chr5:72264368-72264369(+) m6A CDS       24981863 chr5:72264374-72264375(+) m6A CDS       24981863 chr5:72264392-72264393(+) m6A CDS       24981863 chr5:72286335-72286336(+) m6A CDS       24981863 chr5:72286424-72286425(+) m6A CDS       24981863 chr5:72286559-72286560(+) m6A CDS       24981863 chr5:72286577-72286578(+) m6A CDS       24981863 chr5:72286642-72286643(+) m6A CDS       24981863 chr5:72302309-72302310(+) m6A CDS       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1305	Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	FCHO2	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Insoluble cytoplasm K562 cells     - Membrane K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-1305	Panobinostat       6918837 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Paclitaxel       36314 Sorafenib       216239 5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120 Dovitinib       135398510 Crizotinib       11626560

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1305
Interactor2: FCHO2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).