Detail Information

Basic Information:


  VIRBase ID:  

HHID00013679

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1305:           COL25A1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-1305 COL25A1
miRBase
Accession/Entrez ID		 MIMAT0005893 84570
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - AMY//CFEOM5//CLAC//CLAC-P//CLACP

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-1305
rs1391055872 chr4:182169359    G/A
rs1460502740 chr4:182169360    A/G
rs190183451 chr4:182169358    G/A
rs760149578 chr4:182169357    G/T
rs774577022 chr4:182169356    T/C
rs911409575 chr4:182169355    A/C
rs911409575 chr4:182169355    A/G
rs931724077 chr4:182169352    C/G
rs971149992 chr4:182169361    G/A
rs985999312 chr4:182169354    A/G
rs1192955520 chr4:182169349    A/G
rs1240810346 chr4:182169350    C/A
rs1240810346 chr4:182169350    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR COL25A1
chr4:109756910(-) A-I      intronic
chr4:109756787(-) A-I      intronic
chr4:109749479(-) A-I      intronic
chr4:109749451(-) A-I      intronic
chr4:109758123(-) A-I      intronic
chr4:109758148(-) A-I      intronic
chr4:110003717(-) A-I      intronic
chr4:110003700(-) A-I      intronic
chr4:109758152(-) A-I      intronic
chr4:109758159(-) A-I      intronic
chr4:109850866(-) A-I      intronic
chr4:109758175(-) A-I      intronic
chr4:109758178(-) A-I      intronic
chr4:109758229(-) A-I      intronic
chr4:109925914(-) A-I      intronic
chr4:109925886(-) A-I      intronic
chr4:109925820(-) A-I      intronic
chr4:109924165(-) A-I      intronic
chr4:109758069(-) A-I      intronic
chr4:109926320(-) A-I      intronic
chr4:109926270(-) A-I      intronic
chr4:110003693(-) A-I      intronic
chr4:110003688(-) A-I      intronic
chr4:110003678(-) A-I      intronic
chr4:110003677(-) A-I      intronic
chr4:109925975(-) A-I      intronic
chr4:109924833(-) A-I      intronic
chr4:109924845(-) A-I      intronic
chr4:109924873(-) A-I      intronic
chr4:109887925(-) A-I      intronic
chr4:109764229(-) A-I      intronic
chr4:109924835(-) A-I      intronic
chr4:110018686(-) A-I      intronic
chr4:109935432(-) A-I      intronic
chr4:110205457(-) A-I      intronic
chr4:110205469(-) A-I      intronic
chr4:110201966(-) A-I      intronic
chr4:110181831(-) A-I      intronic
chr4:110181790(-) A-I      intronic
chr4:110181776(-) A-I      intronic
chr4:110086765(-) A-I      intronic
chr4:110086751(-) A-I      intronic
chr4:110028124(-) A-I      intronic
chr4:109756848(-) A-I      intronic
chr4:109756912(-) A-I      intronic
chr4:109756913(-) A-I      intronic
chr4:109757104(-) A-I      intronic
chr4:109757229(-) A-I      intronic
chr4:109757231(-) A-I      intronic
chr4:109758032(-) A-I      intronic
chr4:109758043(-) A-I      intronic
chr4:110025477(-) A-I      intronic
chr4:110205481(-) A-I      intronic
chr4:109935406(-) A-I      intronic
chr4:110205550(-) A-I      intronic
chr4:110205545(-) A-I      intronic
chr4:110205505(-) A-I      intronic
chr4:110205498(-) A-I      intronic
chr4:110025326(-) A-I      intronic
chr4:110025466(-) A-I      intronic
chr4:110003718(-) A-I      intronic
chr4:110205459(-) A-I      intronic
chr4:110204652(-) A-I      intronic
chr4:110205494(-) A-I      intronic
chr4:109758113(-) A-I      intronic
chr4:109928168(-) A-I      intronic
chr4:109928148(-) A-I      intronic
chr4:109928101(-) A-I      intronic
chr4:109926414(-) A-I      intronic
chr4:109926394(-) A-I      intronic
chr4:109926348(-) A-I      intronic
chr4:109991191(-) A-I      intronic
chr4:109757166(-) A-I      intronic
chr4:109757766(-) A-I      intronic
chr4:110201896(-) A-I      intronic
chr4:109859769(-) A-I      intronic
chr4:110131029(-) A-I      intronic
chr4:110066996(-) A-I      intronic
chr4:109757972(-) A-I      intronic
chr4:109757984(-) A-I      intronic
chr4:109756987(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase COL25A1
chr4:109732746-109732747(-) m6A 3'UTR       22608085
chr4:109732766-109732767(-) m6A 3'UTR       22608085
chr4:109733885-109733886(-) m6A 3'UTR       22608085
chr4:109733945-109733946(-) m6A 3'UTR       24981863//22608085
chr4:109734029-109734030(-) m6A 3'UTR       25456834//24981863//22608085
chr4:109734159-109734160(-) m6A 3'UTR       25456834//24981863//22608085
chr4:109734182-109734183(-) m6A 3'UTR       24981863//22608085
chr4:109734189-109734190(-) m6A 3'UTR       24981863//22608085
chr4:109734198-109734199(-) m6A 3'UTR       24981863//22608085
chr4:109734261-109734262(-) m6A 3'UTR       24981863//22608085
chr4:109734274-109734275(-) m6A 3'UTR       24981863//22608085
chr4:109734508-109734509(-) m6A 3'UTR       24981863//22608085
chr4:109734571-109734572(-) m6A 3'UTR       24981863//22608085
chr4:109734601-109734602(-) m6A 3'UTR       24981863//22608085
chr4:109734708-109734709(-) m6A 3'UTR       24981863//22608085
chr4:109734756-109734757(-) m6A 3'UTR       24981863//22608085
chr4:109734825-109734826(-) m6A 3'UTR       24981863//22608085
chr4:109734896-109734897(-) m6A 3'UTR       22608085
chr4:109767309-109767310(-) m6A CDS//intron       -
chr4:109767343-109767344(-) m6A CDS       -
chr4:109767352-109767353(-) m6A CDS       -
chr4:109767372-109767373(-) m6A CDS       -
chr4:109773406-109773407(-) m6A CDS       -
chr4:109773415-109773416(-) m6A CDS       -
chr4:109773424-109773425(-) m6A CDS       -
chr4:109780842-109780843(-) m6A CDS       27773536
chr4:109782088-109782089(-) m6A CDS       27773536
chr4:109782104-109782105(-) m6A CDS       27773536
chr4:109783679-109783680(-) m6A CDS//intron       27773536
chr4:109783695-109783696(-) m6A CDS//intron       27773536
chr4:109784480-109784481(-) m6A CDS       27773536
chr4:109784495-109784496(-) m6A CDS       27773536
chr4:109790248-109790249(-) m6A CDS       27773536
chr4:109790273-109790274(-) m6A CDS       27773536
chr4:109790300-109790301(-) m6A CDS       27773536
chr4:109858975-109858976(-) m6A 5'UTR//CDS//intron       27773536
chr4:109858993-109858994(-) m6A 5'UTR//CDS//intron       27773536
chr4:109861734-109861735(-) m6A 5'UTR//CDS//intron       27773536
chr4:109861772-109861773(-) m6A 5'UTR//CDS//intron       27773536
chr4:110223009-110223010(-) m6A CDS       27773536
chr4:110223087-110223088(-) m6A CDS       27773536
chr4:110223103-110223104(-) m6A CDS       27773536//22608085
chr4:110223119-110223120(-) m6A CDS       27773536//22608085
chr4:110223265-110223266(-) m6A 5'UTR//intron       25456834//24981863//27773536//22608085
chr4:110223270-110223271(-) m6A 5'UTR//intron       25456834//24981863//27773536//22608085
chr4:110223527-110223528(-) m6A 5'UTR//intron       27773536
chr4:110223635-110223636(-) m6A 5'UTR//intron       22608085
chr4:110223655-110223656(-) m6A 5'UTR       22608085
chr4:110223673-110223674(-) m6A 5'UTR       22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-1305
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
COL25A1
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-1305
Panobinostat       6918837
Irinotecan       60838
Topotecan       60700
l-685,458       5479543
Palbociclib       5330286
Paclitaxel       36314
Sorafenib       216239
5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120
Dovitinib       135398510
Crizotinib       11626560

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-1305
Interactor2: COL25A1

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT//miRDB//Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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