Detail Information

Basic Information:


  VIRBase ID:  

HHID00013660

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1305:           TM2D2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-1305 TM2D2
miRBase
Accession/Entrez ID		 MIMAT0005893 83877
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - BLP1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-1305
rs1391055872 chr4:182169359    G/A
rs1460502740 chr4:182169360    A/G
rs190183451 chr4:182169358    G/A
rs760149578 chr4:182169357    G/T
rs774577022 chr4:182169356    T/C
rs911409575 chr4:182169355    A/C
rs911409575 chr4:182169355    A/G
rs931724077 chr4:182169352    C/G
rs971149992 chr4:182169361    G/A
rs985999312 chr4:182169354    A/G
rs1192955520 chr4:182169349    A/G
rs1240810346 chr4:182169350    C/A
rs1240810346 chr4:182169350    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TM2D2
chr8:38847876(-) A-I      3'UTR

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TM2D2
chr8:38846478-38846479(-) m6A 3'UTR       27773535
chr8:38846548-38846549(-) m6A 3'UTR       27773535
chr8:38846557-38846558(-) m6A 3'UTR       27773535
chr8:38846585-38846586(-) m6A 3'UTR       24981863//27773535
chr8:38847273-38847274(-) m6A 3'UTR       27773535
chr8:38847412-38847413(-) m6A 3'UTR       27773535
chr8:38847455-38847456(-) m6A 3'UTR       27773535
chr8:38847460-38847461(-) m6A 3'UTR       27773535
chr8:38847525-38847526(-) m6A 3'UTR       27773535
chr8:38847742-38847743(-) m6A 3'UTR       27773535
chr8:38847778-38847779(-) m6A 3'UTR       24981863
chr8:38847788-38847789(-) m6A 3'UTR       24981863
chr8:38847872-38847873(-) m6A 3'UTR       24981863
chr8:38847908-38847909(-) m6A 3'UTR       24981863
chr8:38848033-38848034(-) m6A 3'UTR       27773535
chr8:38848261-38848262(-) m6A 3'UTR       24981863//27773535//22608085
chr8:38848288-38848289(-) m6A 3'UTR       24981863//27773535//22608085
chr8:38848425-38848426(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr8:38848509-38848510(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22608085
chr8:38848605-38848606(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:38848700-38848701(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr8:38848759-38848760(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr8:38848777-38848778(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr8:38848940-38848941(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr8:38848982-38848983(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr8:38849054-38849055(-) m6A CDS//exon       24284625//24209618//24981863//27773535//22608085
chr8:38851074-38851075(-) m6A CDS//exon       24284625//24209618//24981863//27773535//22608085
chr8:38851094-38851095(-) m6A CDS//exon       24284625//24209618//22608085
chr8:38851149-38851150(-) m6A CDS//exon       24209618
chr8:38852857-38852858(-) m6A CDS//exon       26404942//27773535
chr8:38852897-38852898(-) m6A CDS//exon       26404942//27773535
chr8:38852923-38852924(-) m6A CDS//exon       26404942//27773535
chr8:38852963-38852964(-) m6A CDS//intron       27773535
chr8:38852979-38852980(-) m6A CDS//intron       27773535
chr8:38853026-38853027(-) m6A 5'UTR//intron       24981863//27773535//22608085
chr8:38853036-38853037(-) m6A 5'UTR//intron       24981863//27773535//22608085
chr8:38853041-38853042(-) m6A 5'UTR//intron       24981863//27773535//22608085
chr8:38853139-38853140(-) m6A 5'UTR//exon//intron       24284625//24981863//27773535//22608085
chr8:38853146-38853147(-) m6A 5'UTR//intron       24284625//24981863//27773535//22608085
chr8:38853151-38853152(-) m6A 5'UTR//intron       24284625//24981863//27773535//22608085
chr8:38853180-38853181(-) m6A 5'UTR//intron       24284625//24981863//27773535//22608085
chr8:38853245-38853246(-) m6A 5'UTR//intron       24981863//27773535//22608085
chr8:38853277-38853278(-) m6A 5'UTR//intron       24981863//27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-1305
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
TM2D2
Chromatin K562 cells     -
Exosome Blood     -
Nucleus HCC cell line (HepG2)     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-1305
Panobinostat       6918837
Irinotecan       60838
Topotecan       60700
l-685,458       5479543
Palbociclib       5330286
Paclitaxel       36314
Sorafenib       216239
5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120
Dovitinib       135398510
Crizotinib       11626560

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-1305
Interactor2: TM2D2

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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