Basic Information:

  VIRBase ID:  

HHID00013646

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1305:  MIMAT0005893          CEP44:  NM_001040157     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1305	CEP44
miRBase Accession/Entrez ID	MIMAT0005893	80817
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	KIAA1712//PS1TP3

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1305	rs1391055872 chr4:182169359    G/A rs1460502740 chr4:182169360    A/G rs190183451 chr4:182169358    G/A rs760149578 chr4:182169357    G/T rs774577022 chr4:182169356    T/C rs911409575 chr4:182169355    A/C rs911409575 chr4:182169355    A/G rs931724077 chr4:182169352    C/G rs971149992 chr4:182169361    G/A rs985999312 chr4:182169354    A/G rs1192955520 chr4:182169349    A/G rs1240810346 chr4:182169350    C/A rs1240810346 chr4:182169350    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CEP44	chr4:175233559(+) A-I      intronic chr4:175251408(+) A-I      intronic chr4:175250337(+) A-I      intronic chr4:175250202(+) A-I      intronic chr4:175250159(+) A-I      intronic chr4:175246597(+) A-I      intronic chr4:175233496(+) A-I      intronic chr4:175233488(+) A-I      intronic chr4:175226462(+) A-I      intronic chr4:175239356(+) A-I      3'UTR chr4:175239332(+) A-I      3'UTR chr4:175239314(+) A-I      3'UTR chr4:175239315(+) A-I      3'UTR chr4:175246771(+) A-I      intronic chr4:175246623(+) A-I      intronic chr4:175250153(+) A-I      intronic chr4:175246691(+) A-I      intronic chr4:175250227(+) A-I      intronic chr4:175250231(+) A-I      intronic chr4:175240147(+) A-I      3'UTR chr4:175250116(+) A-I      intronic chr4:175246549(+) A-I      intronic chr4:175246664(+) A-I      intronic chr4:175246761(+) A-I      intronic chr4:175250299(+) A-I      intronic chr4:175251384(+) A-I      intronic chr4:175250237(+) A-I      intronic chr4:175233502(+) A-I      intronic chr4:175250198(+) A-I      intronic chr4:175211273(+) A-I      intronic chr4:175236858(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CEP44	chr4:175246549(+) A-I intron -    22327324 chr4:175239285(+) G-A intron -    22484847 chr4:175246549(+) A-G intron -    22484847 chr4:175246664(+) A-G intron -    22484847 chr4:175246691(+) A-G intron -    22484847 chr4:175246771(+) A-G intron -    22484847 chr4:175250116(+) A-G intron -    22484847 chr4:175250151(+) A-G intron -    22484847 chr4:175250153(+) A-G intron -    22484847 chr4:175250227(+) A-G intron -    22484847 chr4:175250299(+) A-G intron -    22484847 chr4:175250336(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CEP44	chr4:175204946-175204947(+) m6A 5'UTR       24981863 chr4:175204972-175204973(+) m6A 5'UTR       24981863 chr4:175205111-175205112(+) m6A 5'UTR//intron       24981863 chr4:175205198-175205199(+) m6A 5'UTR//intron       24209618//24981863//22608085 chr4:175238495-175238496(+) m6A CDS//intron       24981863 chr4:175238872-175238873(+) m6A 3'UTR//intron       24981863 chr4:175238896-175238897(+) m6A 3'UTR//intron       24981863 chr4:175238910-175238911(+) m6A 3'UTR//intron       24981863 chr4:175240837-175240838(+) Y 3'UTR//intron       26075521 chr4:175252883-175252884(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1305	Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	CEP44	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HCC cell line (HepG2)|K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-1305	Panobinostat       6918837 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Paclitaxel       36314 Sorafenib       216239 5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120 Dovitinib       135398510 Crizotinib       11626560

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1305
Interactor2: CEP44

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).