Detail Information

Basic Information:


  VIRBase ID:  

HHID00013618

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1305:           PLEKHF2:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-1305 PLEKHF2
miRBase
Accession/Entrez ID		 MIMAT0005893 79666
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - EAPF//PHAFIN2//ZFYVE18

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-1305
rs1391055872 chr4:182169359    G/A
rs1460502740 chr4:182169360    A/G
rs190183451 chr4:182169358    G/A
rs760149578 chr4:182169357    G/T
rs774577022 chr4:182169356    T/C
rs911409575 chr4:182169355    A/C
rs911409575 chr4:182169355    A/G
rs931724077 chr4:182169352    C/G
rs971149992 chr4:182169361    G/A
rs985999312 chr4:182169354    A/G
rs1192955520 chr4:182169349    A/G
rs1240810346 chr4:182169350    C/A
rs1240810346 chr4:182169350    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PLEKHF2
chr8:96157024(+) A-I      intronic
chr8:96156821(+) A-I      intronic
chr8:96157726(+) A-I      intronic
chr8:96154717(+) A-I      intronic
chr8:96157732(+) A-I      intronic
chr8:96157120(+) A-I      intronic
chr8:96157721(+) A-I      intronic
chr8:96167873(+) A-I      3'UTR
chr8:96157012(+) A-I      intronic
chr8:96154718(+) A-I      intronic
chr8:96156974(+) A-I      intronic
chr8:96151667(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED PLEKHF2
chr8:96156975(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PLEKHF2
chr8:96146137-96146138(+) m6A 5'UTR       24981863
chr8:96146212-96146213(+) m6A 5'UTR       24209618//24981863//22608085
chr8:96146319-96146320(+) m6A 5'UTR//intron       22608085
chr8:96166291-96166292(+) m6A CDS       24284625//24209618//24981863//22575960//22608085
chr8:96166330-96166331(+) m6A CDS       24284625//24209618//24981863//22575960//22608085
chr8:96166499-96166500(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:96166555-96166556(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr8:96166581-96166582(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr8:96166689-96166690(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr8:96166703-96166704(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr8:96166915-96166916(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr8:96166945-96166946(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr8:96167024-96167025(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr8:96167137-96167138(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-1305
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
PLEKHF2
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleoplasm K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-1305
Panobinostat       6918837
Irinotecan       60838
Topotecan       60700
l-685,458       5479543
Palbociclib       5330286
Paclitaxel       36314
Sorafenib       216239
5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120
Dovitinib       135398510
Crizotinib       11626560

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-1305
Interactor2: PLEKHF2

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT//Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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