Detail Information

Basic Information:


  VIRBase ID:  

HHID00013612

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1305:           TTC13:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-1305 TTC13
miRBase
Accession/Entrez ID		 MIMAT0005893 79573
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - -

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-1305
rs1391055872 chr4:182169359    G/A
rs1460502740 chr4:182169360    A/G
rs190183451 chr4:182169358    G/A
rs760149578 chr4:182169357    G/T
rs774577022 chr4:182169356    T/C
rs911409575 chr4:182169355    A/C
rs911409575 chr4:182169355    A/G
rs931724077 chr4:182169352    C/G
rs971149992 chr4:182169361    G/A
rs985999312 chr4:182169354    A/G
rs1192955520 chr4:182169349    A/G
rs1240810346 chr4:182169350    C/A
rs1240810346 chr4:182169350    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TTC13
chr1:231045994(-) A-I      intronic
chr1:231084374(-) A-I      intronic
chr1:231094520(-) A-I      intronic
chr1:231084296(-) A-I      intronic
chr1:231065071(-) A-I      intronic
chr1:231077165(-) A-I      intronic
chr1:231065129(-) A-I      intronic
chr1:231065133(-) A-I      intronic
chr1:231065199(-) A-I      intronic
chr1:231077322(-) A-I      intronic
chr1:231070977(-) A-I      intronic
chr1:231077096(-) A-I      intronic
chr1:231094519(-) A-I      intronic
chr1:231065146(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TTC13
chr1:231065129(-) A-I intron -    15258596
chr1:231065133(-) A-I intron -    15258596
chr1:231065146(-) A-I intron -    15258596
chr1:231065199(-) A-I intron -    15258596
chr1:231094519(-) A-G intron -    22484847
chr1:231094520(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TTC13
chr1:231048454-231048455(-) m6A CDS//exon       27773535
chr1:231048469-231048470(-) m6A CDS//exon       27773535
chr1:231048475-231048476(-) m6A CDS//exon       27773535
chr1:231051941-231051942(-) m6A CDS//exon       27773535
chr1:231051986-231051987(-) m6A CDS//exon       27773535
chr1:231052010-231052011(-) m6A CDS//exon       27773535
chr1:231060616-231060617(-) m6A CDS       -
chr1:231060638-231060639(-) m6A CDS       -
chr1:231060668-231060669(-) m6A CDS       -
chr1:231071923-231071924(-) m6A CDS//exon//intron       -
chr1:231071933-231071934(-) m6A CDS//exon//intron       -
chr1:231071959-231071960(-) m6A CDS//exon//intron       -
chr1:231071966-231071967(-) m6A CDS//exon//intron       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-1305
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
TTC13
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Membrane HCC cell line (HepG2)|K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-1305
Panobinostat       6918837
Irinotecan       60838
Topotecan       60700
l-685,458       5479543
Palbociclib       5330286
Paclitaxel       36314
Sorafenib       216239
5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120
Dovitinib       135398510
Crizotinib       11626560

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-1305
Interactor2: TTC13

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT//miRDB//Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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