Basic Information:

  VIRBase ID:  

HHID00013527

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1305:  MIMAT0005893          RIOK2:  NM_001159749     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1305	RIOK2
miRBase Accession/Entrez ID	MIMAT0005893	55781
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	RIO2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1305	rs1391055872 chr4:182169359    G/A rs1460502740 chr4:182169360    A/G rs190183451 chr4:182169358    G/A rs760149578 chr4:182169357    G/T rs774577022 chr4:182169356    T/C rs911409575 chr4:182169355    A/C rs911409575 chr4:182169355    A/G rs931724077 chr4:182169352    C/G rs971149992 chr4:182169361    G/A rs985999312 chr4:182169354    A/G rs1192955520 chr4:182169349    A/G rs1240810346 chr4:182169350    C/A rs1240810346 chr4:182169350    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RIOK2	chr5:96499795(-) A-I      intronic chr5:96499721(-) A-I      intronic chr5:96499823(-) A-I      intronic chr5:96499729(-) A-I      intronic chr5:96499761(-) A-I      intronic chr5:96499809(-) A-I      intronic chr5:96499820(-) A-I      intronic chr5:96499822(-) A-I      intronic chr5:96499846(-) A-I      intronic chr5:96499847(-) A-I      intronic chr5:96499876(-) A-I      intronic chr5:96500083(-) A-I      intronic chr5:96500093(-) A-I      intronic chr5:96512076(-) A-I      intronic chr5:96500122(-) A-I      intronic chr5:96500123(-) A-I      intronic chr5:96499668(-) A-I      intronic chr5:96510755(-) A-I      intronic chr5:96512183(-) A-I      intronic chr5:96512184(-) A-I      intronic chr5:96512315(-) A-I      intronic chr5:96512216(-) A-I      intronic chr5:96499773(-) A-I      intronic chr5:96499767(-) A-I      intronic chr5:96499704(-) A-I      intronic chr5:96499705(-) A-I      intronic chr5:96499712(-) A-I      intronic chr5:96499725(-) A-I      intronic chr5:96499669(-) A-I      intronic chr5:96499699(-) A-I      intronic chr5:96500118(-) A-I      intronic chr5:96512152(-) A-I      intronic chr5:96500119(-) A-I      intronic chr5:96499765(-) A-I      intronic chr5:96499735(-) A-I      intronic chr5:96512153(-) A-I      intronic chr5:96512160(-) A-I      intronic chr5:96510748(-) A-I      intronic chr5:96512148(-) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RIOK2	chr5:96496573-96496574(-) m6A 3'UTR       27773535 chr5:96496586-96496587(-) m6A 3'UTR       27773535 chr5:96496644-96496645(-) m6A 3'UTR       27773535 chr5:96498816-96498817(-) m6A CDS       27773535 chr5:96498890-96498891(-) m6A CDS       27773535 chr5:96498917-96498918(-) m6A CDS       27773535 chr5:96498926-96498927(-) m6A CDS       27773535 chr5:96500681-96500682(-) m6A 3'UTR//intron       27773535 chr5:96500807-96500808(-) m6A CDS       27773535 chr5:96500813-96500814(-) m6A CDS       27773535 chr5:96502032-96502033(-) m6A CDS//intron       27773535 chr5:96502478-96502479(-) m6A 3'UTR//intron       27773535 chr5:96503163-96503164(-) m6A CDS//intron       27773535//22608085 chr5:96503300-96503301(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr5:96503305-96503306(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr5:96503338-96503339(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr5:96503431-96503432(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22608085 chr5:96503445-96503446(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22608085 chr5:96503452-96503453(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22608085 chr5:96503497-96503498(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22608085 chr5:96503585-96503586(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22608085 chr5:96503625-96503626(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22608085 chr5:96503686-96503687(-) m6A CDS       24284625//24981863//27773535//22608085 chr5:96518821-96518822(-) m6A CDS//intron       24981863 chr5:96518906-96518907(-) m6A 5'UTR       25456834//24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1305	Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	RIOK2	Chromatin K562 cells     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Nucleus K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-1305	Panobinostat       6918837 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Paclitaxel       36314 Sorafenib       216239 5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120 Dovitinib       135398510 Crizotinib       11626560

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1305
Interactor2: RIOK2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).