Detail Information

Basic Information:


  VIRBase ID:  

HHID00013522

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1305:           ENAH:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-1305 ENAH
miRBase
Accession/Entrez ID		 MIMAT0005893 55740
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ENA//MENA//NDPP1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-1305
rs1391055872 chr4:182169359    G/A
rs1460502740 chr4:182169360    A/G
rs190183451 chr4:182169358    G/A
rs760149578 chr4:182169357    G/T
rs774577022 chr4:182169356    T/C
rs911409575 chr4:182169355    A/C
rs911409575 chr4:182169355    A/G
rs931724077 chr4:182169352    C/G
rs971149992 chr4:182169361    G/A
rs985999312 chr4:182169354    A/G
rs1192955520 chr4:182169349    A/G
rs1240810346 chr4:182169350    C/A
rs1240810346 chr4:182169350    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ENAH
chr1:225678975(-) A-I      3'UTR
chr1:225678987(-) A-I      3'UTR
chr1:225679885(-) A-I      3'UTR
chr1:225679932(-) A-I      3'UTR
chr1:225679934(-) A-I      3'UTR
chr1:225820883(-) A-I      intronic
chr1:225807097(-) A-I      intronic
chr1:225820823(-) A-I      intronic
chr1:225797535(-) A-I      intronic
chr1:225826043(-) A-I      intronic
chr1:225797560(-) A-I      intronic
chr1:225797534(-) A-I      intronic
chr1:225797530(-) A-I      intronic
chr1:225797566(-) A-I      intronic
chr1:225797568(-) A-I      intronic
chr1:225797512(-) A-I      intronic
chr1:225819193(-) A-I      intronic
chr1:225819199(-) A-I      intronic
chr1:225819213(-) A-I      intronic
chr1:225826049(-) A-I      intronic
chr1:225826079(-) A-I      intronic
chr1:225826080(-) A-I      intronic
chr1:225819214(-) A-I      intronic
chr1:225820893(-) A-I      intronic
chr1:225820909(-) A-I      intronic
chr1:225820915(-) A-I      intronic
chr1:225819224(-) A-I      intronic
chr1:225808036(-) A-I      intronic
chr1:225820866(-) A-I      intronic
chr1:225820869(-) A-I      intronic
chr1:225820873(-) A-I      intronic
chr1:225820877(-) A-I      intronic
chr1:225808595(-) A-I      intronic
chr1:225810473(-) A-I      intronic
chr1:225810353(-) A-I      intronic
chr1:225678952(-) A-I      3'UTR
chr1:225678095(-) A-I      3'UTR
chr1:225678109(-) A-I      3'UTR
chr1:225739977(-) A-I      intronic
chr1:225678878(-) A-I      3'UTR
chr1:225690127(-) A-I      intronic
chr1:225678919(-) A-I      3'UTR
chr1:225701546(-) A-I      intronic
chr1:225701550(-) A-I      intronic
chr1:225678939(-) A-I      3'UTR
chr1:225701570(-) A-I      intronic
chr1:225701622(-) A-I      intronic
chr1:225701652(-) A-I      intronic
chr1:225678954(-) A-I      3'UTR
chr1:225679015(-) A-I      3'UTR
chr1:225701977(-) A-I      intronic
chr1:225679023(-) A-I      3'UTR
chr1:225702104(-) A-I      intronic
chr1:225679024(-) A-I      3'UTR
chr1:225679033(-) A-I      3'UTR
chr1:225679043(-) A-I      3'UTR
chr1:225679046(-) A-I      3'UTR
chr1:225729698(-) A-I      intronic
chr1:225679048(-) A-I      3'UTR
chr1:225729706(-) A-I      intronic
chr1:225730609(-) A-I      intronic
chr1:225730621(-) A-I      intronic
chr1:225679061(-) A-I      3'UTR
chr1:225679852(-) A-I      3'UTR
chr1:225679912(-) A-I      3'UTR
chr1:225679916(-) A-I      3'UTR
chr1:225730637(-) A-I      intronic
chr1:225730638(-) A-I      intronic
chr1:225679926(-) A-I      3'UTR
chr1:225736812(-) A-I      intronic
chr1:225739967(-) A-I      intronic
chr1:225678175(-) A-I      3'UTR
chr1:225702123(-) A-I      intronic
chr1:225740112(-) A-I      intronic
chr1:225829540(-) A-I      intronic
chr1:225687255(-) A-I      intronic
chr1:225825603(-) A-I      intronic
chr1:225740113(-) A-I      intronic
chr1:225825591(-) A-I      intronic
chr1:225825050(-) A-I      intronic
chr1:225740923(-) A-I      intronic
chr1:225825047(-) A-I      intronic
chr1:225825009(-) A-I      intronic
chr1:225821025(-) A-I      intronic
chr1:225821024(-) A-I      intronic
chr1:225820821(-) A-I      intronic
chr1:225820812(-) A-I      intronic
chr1:225746433(-) A-I      intronic
chr1:225820810(-) A-I      intronic
chr1:225813356(-) A-I      intronic
chr1:225675920(-) A-I      3'UTR
chr1:225675925(-) A-I      3'UTR
chr1:225750641(-) A-I      intronic
chr1:225751914(-) A-I      intronic
chr1:225751915(-) A-I      intronic
chr1:225751919(-) A-I      intronic
chr1:225675957(-) A-I      3'UTR
chr1:225677406(-) A-I      3'UTR
chr1:225677429(-) A-I      3'UTR
chr1:225677434(-) A-I      3'UTR
chr1:225677439(-) A-I      3'UTR
chr1:225677479(-) A-I      3'UTR
chr1:225677542(-) A-I      3'UTR
chr1:225677551(-) A-I      3'UTR
chr1:225677589(-) A-I      3'UTR
chr1:225779295(-) A-I      intronic
chr1:225779310(-) A-I      intronic
chr1:225797435(-) A-I      intronic
chr1:225677594(-) A-I      3'UTR
chr1:225797469(-) A-I      intronic
chr1:225677604(-) A-I      3'UTR
chr1:225677643(-) A-I      3'UTR
chr1:225678053(-) A-I      3'UTR
chr1:225807053(-) A-I      intronic
chr1:225687262(-) A-I      intronic
chr1:225807082(-) A-I      intronic
chr1:225678058(-) A-I      3'UTR
chr1:225809092(-) A-I      intronic
chr1:225812080(-) A-I      intronic
chr1:225812091(-) A-I      intronic
chr1:225813279(-) A-I      intronic
chr1:225813321(-) A-I      intronic
chr1:225813355(-) A-I      intronic
chr1:225687274(-) A-I      intronic
chr1:225678083(-) A-I      3'UTR
chr1:225810105(-) A-I      intronic
chr1:225825013(-) A-I      intronic
chr1:225701899(-) A-I      intronic
chr1:225796396(-) A-I      intronic
chr1:225821031(-) A-I      intronic
chr1:225694069(-) A-I      intronic
chr1:225739911(-) A-I      intronic
chr1:225678192(-) A-I      3'UTR
chr1:225678153(-) A-I      3'UTR
chr1:225679902(-) A-I      3'UTR
chr1:225736824(-) A-I      intronic
chr1:225679814(-) A-I      3'UTR
chr1:225678163(-) A-I      3'UTR
chr1:225748125(-) A-I      intronic
chr1:225678219(-) A-I      3'UTR
chr1:225678112(-) A-I      3'UTR
chr1:225677568(-) A-I      3'UTR
chr1:225679118(-) A-I      3'UTR
chr1:225789033(-) A-I      intronic
chr1:225678107(-) A-I      3'UTR
chr1:225677407(-) A-I      3'UTR
chr1:225748332(-) A-I      intronic
chr1:225819194(-) A-I      intronic
chr1:225678910(-) A-I      3'UTR
chr1:225679876(-) A-I      3'UTR
chr1:225678229(-) A-I      3'UTR
chr1:225678949(-) A-I      3'UTR
chr1:225813382(-) A-I      intronic
chr1:225678940(-) A-I      3'UTR
chr1:225804545(-) A-I      intronic
chr1:225677485(-) A-I      3'UTR
chr1:225788290(-) A-I      intronic
chr1:225813317(-) A-I      intronic
chr1:225702099(-) A-I      intronic
chr1:225828704(-) A-I      intronic
chr1:225678166(-) A-I      3'UTR
chr1:225679126(-) A-I      3'UTR
chr1:225677588(-) A-I      3'UTR
chr1:225679989(-) A-I      3'UTR
chr1:225826157(-) A-I      intronic
chr1:225694088(-) A-I      intronic
chr1:225810055(-) A-I      intronic
chr1:225749818(-) A-I      intronic
chr1:225826069(-) A-I      intronic
chr1:225678935(-) A-I      3'UTR
chr1:225676015(-) A-I      3'UTR
chr1:225779410(-) A-I      intronic
chr1:225678167(-) A-I      3'UTR
chr1:225678951(-) A-I      3'UTR
chr1:225829601(-) A-I      intronic
chr1:225779405(-) A-I      intronic
chr1:225677488(-) A-I      3'UTR
chr1:225678254(-) A-I      3'UTR
chr1:225677466(-) A-I      3'UTR
chr1:225831465(-) A-I      intronic
chr1:225701634(-) A-I      intronic
chr1:225812171(-) A-I      intronic
chr1:225730566(-) A-I      intronic
chr1:225829478(-) A-I      intronic
chr1:225829338(-) A-I      intronic
chr1:225679948(-) A-I      3'UTR
chr1:225677599(-) A-I      3'UTR
chr1:225678137(-) A-I      3'UTR
chr1:225812410(-) A-I      intronic
chr1:225678118(-) A-I      3'UTR
chr1:225679101(-) A-I      3'UTR
chr1:225826136(-) A-I      intronic
chr1:225678865(-) A-I      3'UTR
chr1:225677645(-) A-I      3'UTR
chr1:225833529(-) A-I      intronic
chr1:225819154(-) A-I      intronic
chr1:225730533(-) A-I      intronic
chr1:225749804(-) A-I      intronic
chr1:225679117(-) A-I      3'UTR
chr1:225678214(-) A-I      3'UTR
chr1:225729787(-) A-I      intronic
chr1:225797638(-) A-I      intronic
chr1:225675993(-) A-I      3'UTR
chr1:225677425(-) A-I      3'UTR
chr1:225709231(-) A-I      intronic
chr1:225677569(-) A-I      3'UTR
chr1:225679890(-) A-I      3'UTR
chr1:225729617(-) A-I      intronic
chr1:225730538(-) A-I      intronic
chr1:225779367(-) A-I      intronic
chr1:225729816(-) A-I      intronic
chr1:225677386(-) A-I      3'UTR
chr1:225807244(-) A-I      intronic
chr1:225829787(-) A-I      intronic
chr1:225808128(-) A-I      intronic
chr1:225826064(-) A-I      intronic
chr1:225679925(-) A-I      3'UTR
chr1:225810047(-) A-I      intronic
chr1:225678932(-) A-I      3'UTR
chr1:225678911(-) A-I      3'UTR
chr1:225678915(-) A-I      3'UTR
chr1:225797434(-) A-I      intronic
chr1:225678981(-) A-I      3'UTR
chr1:225701639(-) A-I      intronic
chr1:225687252(-) A-I      intronic
chr1:225677529(-) A-I      3'UTR
chr1:225678151(-) A-I      3'UTR
chr1:225752248(-) A-I      intronic
chr1:225768567(-) A-I      intronic
chr1:225677556(-) A-I      3'UTR
chr1:225701437(-) A-I      intronic
chr1:225678997(-) A-I      3'UTR
chr1:225729810(-) A-I      intronic
chr1:225810031(-) A-I      intronic
chr1:225826025(-) A-I      intronic
chr1:225797562(-) A-I      intronic
chr1:225825999(-) A-I      intronic
chr1:225779385(-) A-I      intronic
chr1:225806988(-) A-I      intronic
chr1:225768457(-) A-I      intronic
chr1:225677394(-) A-I      3'UTR
chr1:225801793(-) A-I      intronic
chr1:225812178(-) A-I      intronic
chr1:225825616(-) A-I      intronic
chr1:225675966(-) A-I      3'UTR
chr1:225677388(-) A-I      3'UTR
chr1:225797439(-) A-I      intronic
chr1:225679038(-) A-I      3'UTR
chr1:225678213(-) A-I      3'UTR
chr1:225829466(-) A-I      intronic
chr1:225678958(-) A-I      3'UTR
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ENAH
chr1:225679814(-) A-I exon 3'UTR    15258596
chr1:225679890(-) A-I exon 3'UTR    15258596
chr1:225679989(-) A-I exon 3'UTR    15258596
chr1:225678109(-) A-I exon 3'UTR    21960545
chr1:225678153(-) A-I exon 3'UTR    21960545
chr1:225678254(-) A-I exon 3'UTR    21960545
chr1:225702158(-) A-I intron -    21960545
chr1:225748334(-) A-I intron -    21960545
chr1:225751915(-) A-I intron -    21960545
chr1:225751919(-) A-I intron -    21960545
chr1:225751955(-) A-I intron -    21960545
chr1:225769605(-) A-I intron -    21960545
chr1:225788235(-) A-I intron -    21960545
chr1:225808128(-) A-I intron -    21960545
chr1:225808225(-) A-I intron -    21960545
chr1:225810105(-) A-I intron -    21960545
chr1:225812171(-) A-I intron -    21960545
chr1:225812194(-) A-I intron -    21960545
chr1:225813317(-) A-I intron -    21960545
chr1:225813382(-) A-I intron -    21960545
chr1:225822974(-) A-I intron -    21960545
chr1:225823011(-) A-I intron -    21960545
chr1:225823020(-) A-I intron -    21960545
chr1:225825009(-) A-I intron -    21960545
chr1:225825013(-) A-I intron -    21960545
chr1:225825568(-) A-I intron -    21960545
chr1:225825591(-) A-I intron -    21960545
chr1:225825616(-) A-I intron -    21960545

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ENAH
chr1:225674550-225674551(-) m6A 3'UTR       27773535//22608085
chr1:225674692-225674693(-) m6A 3'UTR       24284625//27773535//22608085
chr1:225674721-225674722(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr1:225674739-225674740(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr1:225674925-225674926(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22608085
chr1:225674951-225674952(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22575960//22608085
chr1:225674986-225674987(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22575960//22608085
chr1:225675004-225675005(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22575960//22608085
chr1:225675026-225675027(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22575960//22608085
chr1:225675032-225675033(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22575960//22608085
chr1:225675039-225675040(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22575960//22608085
chr1:225675095-225675096(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22608085
chr1:225675116-225675117(-) m6A 3'UTR       24284625//25456834//27773535//22608085
chr1:225681853-225681854(-) m6A 3'UTR       27773535
chr1:225681902-225681903(-) m6A 3'UTR       27773535
chr1:225685196-225685197(-) m6A 3'UTR//exon       24284625//24981863//27773535//22575960//22608085
chr1:225685317-225685318(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22575960//22608085
chr1:225685342-225685343(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22575960//22608085
chr1:225685362-225685363(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr1:225685398-225685399(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr1:225685421-225685422(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr1:225685451-225685452(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr1:225685471-225685472(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr1:225685500-225685501(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr1:225688717-225688718(-) m6A CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085
chr1:225688771-225688772(-) m6A CDS//exon       24981863//27773535//22608085
chr1:225688826-225688827(-) m6A exon//intron       27773535
chr1:225695692-225695693(-) m6A CDS//exon       27773535
chr1:225695705-225695706(-) m6A CDS//exon       27773535
chr1:225696098-225696099(-) m6A exon//intron       27773535
chr1:225696154-225696155(-) m6A exon//intron       27773535
chr1:225696190-225696191(-) m6A exon//intron       27773535
chr1:225700365-225700366(-) m6A CDS//exon       24209618//24981863//27773535
chr1:225700376-225700377(-) m6A CDS//exon       24209618//24981863//27773535
chr1:225700381-225700382(-) m6A CDS//exon       24209618//24981863//27773535
chr1:225700631-225700632(-) m6A CDS//exon       24209618//27773535
chr1:225700654-225700655(-) m6A CDS//exon       24209618//27773535
chr1:225700671-225700672(-) m6A CDS//exon       24209618//27773535
chr1:225702315-225702316(-) m6A CDS//exon       24209618//27773535
chr1:225702342-225702343(-) m6A CDS//exon       24209618//27773535
chr1:225702361-225702362(-) m6A CDS//exon       24209618//27773535
chr1:225702588-225702589(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//27773536
chr1:225702722-225702723(-) m6A exon//intron       24209618//27773535//27773536
chr1:225702746-225702747(-) m6A exon//intron       27773535
chr1:225702756-225702757(-) m6A exon//intron       27773535
chr1:225702782-225702783(-) m6A exon//intron       27773535
chr1:225704912-225704913(-) m6A CDS       24209618//27773536
chr1:225704962-225704963(-) m6A CDS       24209618//25456834//24981863//27773535//27371828//27773536//22575960
chr1:225704977-225704978(-) m6A CDS       24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr1:225704987-225704988(-) m6A CDS       24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr1:225705391-225705392(-) m6A CDS//intron       24284625//24981863//27773535
chr1:225705415-225705416(-) m6A CDS//intron       24284625//24981863//27773535
chr1:225705421-225705422(-) m6A CDS//intron       24284625//24981863//27773535
chr1:225705679-225705680(-) m6A CDS//intron       24981863//27773535
chr1:225706883-225706884(-) m6A CDS//intron       24209618//25456834//24981863//27773535//27773536//22608085
chr1:225706939-225706940(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr1:225706990-225706991(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr1:225707014-225707015(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr1:225707036-225707037(-) Tm CDS//exon       -
chr1:225707116-225707117(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr1:225707134-225707135(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr1:225707140-225707141(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr1:225707254-225707255(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr1:225718318-225718319(-) m6A CDS//exon       24981863//27773535//27371828
chr1:225718323-225718324(-) m6A CDS//exon       24981863//27773535//27371828
chr1:225723237-225723238(-) m6A CDS//intron       27773535
chr1:225742610-225742611(-) m6A CDS//exon       27773535
chr1:225742624-225742625(-) Y CDS//exon       26075521
chr1:225742704-225742705(-) m6A CDS//exon       27773535
chr1:225742730-225742731(-) m6A CDS//exon       27773535
chr1:225742774-225742775(-) m6A CDS//exon       26404942//27773535
chr1:225754957-225754958(-) m6A CDS//exon       26404942//27773535
chr1:225755112-225755113(-) m6A CDS//exon       27773535
chr1:225840459-225840460(-) m6A 5'UTR       24284625//27773536
chr1:225840505-225840506(-) m6A 5'UTR       24284625//27773536
chr1:225840638-225840639(-) m6A 5'UTR       24284625//24209618//25456834//27371828//27773536//22575960
chr1:225840673-225840674(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27371828//27773536//22575960

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-1305
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
ENAH
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Exosome Blood     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus HeLa-S3 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-1305
Panobinostat       6918837
Irinotecan       60838
Topotecan       60700
l-685,458       5479543
Palbociclib       5330286
Paclitaxel       36314
Sorafenib       216239
5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120
Dovitinib       135398510
Crizotinib       11626560

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-1305
Interactor2: ENAH

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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