Basic Information:

  VIRBase ID:  

HHID00013512

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1305:  MIMAT0005893          VPS50:  NM_017667     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1305	VPS50
miRBase Accession/Entrez ID	MIMAT0005893	55610
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CCDC132//VPS54L

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1305	rs1391055872 chr4:182169359    G/A rs1460502740 chr4:182169360    A/G rs190183451 chr4:182169358    G/A rs760149578 chr4:182169357    G/T rs774577022 chr4:182169356    T/C rs911409575 chr4:182169355    A/C rs911409575 chr4:182169355    A/G rs931724077 chr4:182169352    C/G rs971149992 chr4:182169361    G/A rs985999312 chr4:182169354    A/G rs1192955520 chr4:182169349    A/G rs1240810346 chr4:182169350    C/A rs1240810346 chr4:182169350    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	VPS50	chr7:92890155(+) A-I      intronic chr7:92890149(+) A-I      intronic chr7:92890213(+) A-I      intronic chr7:92890801(+) A-I      intronic chr7:92890802(+) A-I      intronic chr7:92890812(+) A-I      intronic chr7:92890830(+) A-I      intronic chr7:92890838(+) A-I      intronic chr7:92890182(+) A-I      intronic chr7:92890879(+) A-I      intronic chr7:92890843(+) A-I      intronic chr7:92890869(+) A-I      intronic chr7:92890840(+) A-I      intronic chr7:92890160(+) A-I      intronic chr7:92890191(+) A-I      intronic chr7:92890039(+) A-I      intronic chr7:92949951(+) A-I      intronic chr7:92891013(+) A-I      intronic chr7:92890135(+) A-I      intronic chr7:92866295(+) A-I      intronic chr7:92890188(+) A-I      intronic chr7:92890735(+) A-I      intronic chr7:92949720(+) A-I      NonSyn:Thr->Ala

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	VPS50	chr7:92938203-92938204(+) m6A 3'UTR//CDS//exon       24981863 chr7:92938214-92938215(+) m6A 3'UTR//CDS//exon       24981863 chr7:92987699-92987700(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085 chr7:92987705-92987706(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085 chr7:92987731-92987732(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085 chr7:92987751-92987752(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr7:92987849-92987850(+) m6A 3'UTR//exon       24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1305	Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	VPS50	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-1305	Panobinostat       6918837 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Paclitaxel       36314 Sorafenib       216239 5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120 Dovitinib       135398510 Crizotinib       11626560

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1305
Interactor2: VPS50

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).