Detail Information

Basic Information:


  VIRBase ID:  

HHID00013481

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1305:           GID8:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-1305 GID8
miRBase
Accession/Entrez ID		 MIMAT0005893 54994
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - C20orf11//TWA1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-1305
rs1391055872 chr4:182169359    G/A
rs1460502740 chr4:182169360    A/G
rs190183451 chr4:182169358    G/A
rs760149578 chr4:182169357    G/T
rs774577022 chr4:182169356    T/C
rs911409575 chr4:182169355    A/C
rs911409575 chr4:182169355    A/G
rs931724077 chr4:182169352    C/G
rs971149992 chr4:182169361    G/A
rs985999312 chr4:182169354    A/G
rs1192955520 chr4:182169349    A/G
rs1240810346 chr4:182169350    C/A
rs1240810346 chr4:182169350    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR GID8
chr20:61571854(+) A-I      intronic
chr20:61570395(+) A-I      intronic
chr20:61573565(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase GID8
chr20:61572871-61572872(+) m6A CDS       24981863
chr20:61572936-61572937(+) m6A CDS       24981863
chr20:61572942-61572943(+) m6A CDS       24981863
chr20:61572957-61572958(+) m6A CDS       24981863
chr20:61574424-61574425(+) Am CDS       -
chr20:61574882-61574883(+) m6A CDS       24981863
chr20:61575015-61575016(+) m6A CDS       24284625//24209618//22575960//22608085
chr20:61576149-61576150(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr20:61576167-61576168(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr20:61576196-61576197(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr20:61576229-61576230(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr20:61576310-61576311(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr20:61576359-61576360(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr20:61576436-61576437(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr20:61576659-61576660(+) m6A 3'UTR       24284625//24209618//24981863
chr20:61576908-61576909(+) m6A 3'UTR       24209618
chr20:61576931-61576932(+) m6A 3'UTR       24209618
chr20:61577311-61577312(+) m6A 3'UTR       -
chr20:61577380-61577381(+) m6A 3'UTR       -
chr20:61577443-61577444(+) m6A 3'UTR       -
chr20:61577700-61577701(+) m6A 3'UTR       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-1305
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
GID8
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Insoluble cytoplasm K562 cells     -
Membrane HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-1305
Panobinostat       6918837
Irinotecan       60838
Topotecan       60700
l-685,458       5479543
Palbociclib       5330286
Paclitaxel       36314
Sorafenib       216239
5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120
Dovitinib       135398510
Crizotinib       11626560

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-1305
Interactor2: GID8

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT//Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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