Basic Information:

  VIRBase ID:  

HHID00013441

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1305:  MIMAT0005893          GSKIP:  NM_001271905     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1305	GSKIP
miRBase Accession/Entrez ID	MIMAT0005893	51527
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	C14orf129//HSPC210

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1305	rs1391055872 chr4:182169359    G/A rs1460502740 chr4:182169360    A/G rs190183451 chr4:182169358    G/A rs760149578 chr4:182169357    G/T rs774577022 chr4:182169356    T/C rs911409575 chr4:182169355    A/C rs911409575 chr4:182169355    A/G rs931724077 chr4:182169352    C/G rs971149992 chr4:182169361    G/A rs985999312 chr4:182169354    A/G rs1192955520 chr4:182169349    A/G rs1240810346 chr4:182169350    C/A rs1240810346 chr4:182169350    C/T

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	GSKIP	chr14:96829823-96829824(+) m1A 5'UTR       26863410 chr14:96829884-96829885(+) m1A 5'UTR//exon       26863196//26863410 chr14:96830369-96830370(+) m6A 5'UTR//intron       25456834 chr14:96830443-96830444(+) m6A 5'UTR//intron       24209618 chr14:96830456-96830457(+) m6A 5'UTR//intron       24209618 chr14:96830759-96830760(+) m6A 5'UTR//intron       24209618//25456834//24981863//22608085 chr14:96830765-96830766(+) m6A 5'UTR//intron       24209618//25456834//24981863//22608085 chr14:96830778-96830779(+) m6A 5'UTR//intron       24209618//25456834//24981863//22608085 chr14:96830899-96830900(+) m6A 5'UTR//intron       24284625//22608085 chr14:96830940-96830941(+) m6A 5'UTR//intron       - chr14:96830996-96830997(+) m6A 5'UTR//intron       24981863 chr14:96831097-96831098(+) m6A 5'UTR//intron       25456834//24981863//22608085 chr14:96831119-96831120(+) m6A 5'UTR//intron       25456834//24981863//22608085 chr14:96831204-96831205(+) m6A 5'UTR//intron       24284625//25456834//24981863//22608085 chr14:96831311-96831312(+) m6A 5'UTR//intron       22608085 chr14:96831324-96831325(+) m6A 5'UTR//intron       22608085 chr14:96845319-96845320(+) m6A 5'UTR//intron       24981863 chr14:96845346-96845347(+) m6A 5'UTR//intron       24981863 chr14:96848590-96848591(+) m6A CDS       25456834//24981863//22608085 chr14:96848665-96848666(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr14:96848678-96848679(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr14:96848791-96848792(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr14:96848804-96848805(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr14:96848820-96848821(+) m6A CDS       24284625//24209618//24981863//22608085 chr14:96851050-96851051(+) Y intron       25219674 chr14:96851901-96851902(+) m6A CDS       24284625//24209618//24981863//22608085 chr14:96851916-96851917(+) m6A CDS       24284625//24209618//24981863//22608085 chr14:96851987-96851988(+) m6A CDS       24284625//25456834//24981863//26404942//22608085 chr14:96852011-96852012(+) m6A CDS       24284625//25456834//24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1305	Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	GSKIP	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-1305	Panobinostat       6918837 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Paclitaxel       36314 Sorafenib       216239 5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120 Dovitinib       135398510 Crizotinib       11626560

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1305
Interactor2: GSKIP

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).