Basic Information:

  VIRBase ID:  

HHID00013347

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1305:  MIMAT0005893          NNT:  NM_001331026     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1305	NNT
miRBase Accession/Entrez ID	MIMAT0005893	23530
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	GCCD4

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1305	rs1391055872 chr4:182169359    G/A rs1460502740 chr4:182169360    A/G rs190183451 chr4:182169358    G/A rs760149578 chr4:182169357    G/T rs774577022 chr4:182169356    T/C rs911409575 chr4:182169355    A/C rs911409575 chr4:182169355    A/G rs931724077 chr4:182169352    C/G rs971149992 chr4:182169361    G/A rs985999312 chr4:182169354    A/G rs1192955520 chr4:182169349    A/G rs1240810346 chr4:182169350    C/A rs1240810346 chr4:182169350    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	NNT	chr5:43681711(+) A-I      intronic chr5:43681619(+) A-I      intronic chr5:43681627(+) A-I      intronic chr5:43681631(+) A-I      intronic chr5:43681702(+) A-I      intronic chr5:43605524(+) A-I      intronic chr5:43681113(+) A-I      intronic chr5:43681170(+) A-I      intronic chr5:43681251(+) A-I      intronic chr5:43681287(+) A-I      intronic chr5:43605471(+) A-I      intronic chr5:43681519(+) A-I      intronic chr5:43681540(+) A-I      intronic chr5:43681580(+) A-I      intronic chr5:43604818(+) A-I      intronic chr5:43681177(+) A-I      intronic chr5:43681107(+) A-I      intronic chr5:43604886(+) A-I      intronic chr5:43681108(+) A-I      intronic chr5:43681570(+) A-I      intronic chr5:43604835(+) A-I      intronic chr5:43681160(+) A-I      intronic chr5:43681606(+) A-I      intronic chr5:43681531(+) A-I      intronic chr5:43604891(+) A-I      intronic chr5:43608313(+) A-I      intronic chr5:43681196(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	NNT	chr5:43659697(+) G-A intron -    22484847 chr5:43681107(+) A-G intron -    22484847 chr5:43681108(+) A-G intron -    22484847 chr5:43681160(+) A-G intron -    22484847 chr5:43681177(+) A-G intron -    22484847 chr5:43681196(+) A-G intron -    22484847 chr5:43681531(+) A-G intron -    22484847 chr5:43681570(+) A-G intron -    22484847 chr5:43681676(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	NNT	chr5:43602900-43602901(+) m6A 5'UTR//intron       24284625 chr5:43602912-43602913(+) m6A 5'UTR//intron       24284625 chr5:43602966-43602967(+) m6A 5'UTR//intron       24284625 chr5:43616006-43616007(+) m6A CDS       - chr5:43628321-43628322(+) Y CDS       26075521 chr5:43644411-43644412(+) m6A CDS       24981863 chr5:43644737-43644738(+) m6A CDS       24981863 chr5:43704557-43704558(+) m6A 3'UTR       24284625//24981863//22608085 chr5:43704625-43704626(+) m6A 3'UTR       24284625//24981863//22608085 chr5:43704646-43704647(+) m6A 3'UTR       24284625//24981863//22608085 chr5:43704842-43704843(+) m6A 3'UTR       22575960 chr5:43704864-43704865(+) m6A 3'UTR       22575960 chr5:43704905-43704906(+) m6A 3'UTR       22575960 chr5:43704962-43704963(+) m6A 3'UTR       22575960 chr5:43704972-43704973(+) m6A 3'UTR       22575960 chr5:43705108-43705109(+) m6A 3'UTR       24981863 chr5:43705136-43705137(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1305	Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	NNT	Chromatin K562 cells     - Cytosol K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-1305	Panobinostat       6918837 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Paclitaxel       36314 Sorafenib       216239 5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120 Dovitinib       135398510 Crizotinib       11626560

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1305
Interactor2: NNT

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).