Basic Information:

  VIRBase ID:  

HHID00013300

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1305:  MIMAT0005893          WWP1:  NM_007013     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1305	WWP1
miRBase Accession/Entrez ID	MIMAT0005893	11059
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	AIP5//hSDRP1//Tiul1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1305	rs1391055872 chr4:182169359    G/A rs1460502740 chr4:182169360    A/G rs190183451 chr4:182169358    G/A rs760149578 chr4:182169357    G/T rs774577022 chr4:182169356    T/C rs911409575 chr4:182169355    A/C rs911409575 chr4:182169355    A/G rs931724077 chr4:182169352    C/G rs971149992 chr4:182169361    G/A rs985999312 chr4:182169354    A/G rs1192955520 chr4:182169349    A/G rs1240810346 chr4:182169350    C/A rs1240810346 chr4:182169350    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	WWP1	chr8:87415586(+) A-I      intronic chr8:87476035(+) A-I      intronic chr8:87399845(+) A-I      intronic chr8:87476050(+) A-I      intronic chr8:87476043(+) A-I      intronic chr8:87394824(+) A-I      intronic chr8:87415573(+) A-I      intronic chr8:87370805(+) A-I      intronic chr8:87394837(+) A-I      intronic chr8:87394839(+) A-I      intronic chr8:87476040(+) A-I      intronic chr8:87477690(+) A-I      intronic chr8:87399987(+) A-I      intronic chr8:87387104(+) A-I      intronic chr8:87414534(+) A-I      intronic chr8:87476028(+) A-I      intronic chr8:87475732(+) A-I      intronic chr8:87475697(+) A-I      intronic chr8:87475685(+) A-I      intronic chr8:87363626(+) A-I      intronic chr8:87363624(+) A-I      intronic chr8:87399982(+) A-I      intronic chr8:87363611(+) A-I      intronic chr8:87387131(+) A-I      intronic chr8:87475653(+) A-I      intronic chr8:87463358(+) A-I      intronic chr8:87463264(+) A-I      intronic chr8:87463263(+) A-I      intronic chr8:87415556(+) A-I      intronic chr8:87463262(+) A-I      intronic chr8:87459535(+) A-I      intronic chr8:87442767(+) A-I      intronic chr8:87387177(+) A-I      intronic chr8:87388669(+) A-I      intronic chr8:87421537(+) A-I      intronic chr8:87421592(+) A-I      intronic chr8:87421602(+) A-I      intronic chr8:87421855(+) A-I      intronic chr8:87394766(+) A-I      intronic chr8:87399975(+) A-I      intronic chr8:87399962(+) A-I      intronic chr8:87399872(+) A-I      intronic chr8:87399854(+) A-I      intronic chr8:87476848(+) A-I      intronic chr8:87406775(+) A-I      intronic chr8:87406758(+) A-I      intronic chr8:87395851(+) A-I      intronic chr8:87476815(+) A-I      intronic chr8:87476163(+) A-I      intronic chr8:87476159(+) A-I      intronic chr8:87476128(+) A-I      intronic chr8:87399926(+) A-I      intronic chr8:87421969(+) A-I      intronic chr8:87442565(+) A-I      intronic chr8:87421970(+) A-I      intronic chr8:87421995(+) A-I      intronic chr8:87476034(+) A-I      intronic chr8:87421947(+) A-I      intronic chr8:87421943(+) A-I      intronic chr8:87421940(+) A-I      intronic chr8:87421939(+) A-I      intronic chr8:87476884(+) A-I      intronic chr8:87476849(+) A-I      intronic chr8:87477702(+) A-I      intronic chr8:87399805(+) A-I      intronic chr8:87395860(+) A-I      intronic chr8:87394877(+) A-I      intronic chr8:87477704(+) A-I      intronic chr8:87394856(+) A-I      intronic chr8:87394787(+) A-I      intronic chr8:87394775(+) A-I      intronic chr8:87409064(+) A-I      intronic chr8:87421543(+) A-I      intronic chr8:87405657(+) A-I      intronic chr8:87442697(+) A-I      intronic chr8:87421516(+) A-I      intronic chr8:87422009(+) A-I      intronic chr8:87463385(+) A-I      intronic chr8:87371006(+) A-I      intronic chr8:87476824(+) A-I      intronic chr8:87376888(+) A-I      intronic chr8:87442639(+) A-I      intronic chr8:87398545(+) A-I      intronic chr8:87463186(+) A-I      intronic chr8:87399871(+) A-I      intronic chr8:87399936(+) A-I      intronic chr8:87399881(+) A-I      intronic chr8:87372024(+) A-I      intronic chr8:87451685(+) A-I      intronic chr8:87476205(+) A-I      intronic chr8:87442596(+) A-I      intronic chr8:87376924(+) A-I      intronic chr8:87475616(+) A-I      intronic chr8:87476928(+) A-I      intronic chr8:87477703(+) A-I      intronic chr8:87476125(+) A-I      intronic chr8:87476277(+) A-I      intronic chr8:87451686(+) A-I      intronic chr8:87451318(+) A-I      intronic chr8:87376885(+) A-I      intronic chr8:87399868(+) A-I      intronic chr8:87442359(+) A-I      intronic chr8:87475636(+) A-I      intronic chr8:87421888(+) A-I      intronic chr8:87399958(+) A-I      intronic chr8:87476179(+) A-I      intronic chr8:87476219(+) A-I      intronic chr8:87365986(+) A-I      intronic chr8:87451689(+) A-I      intronic chr8:87405555(+) A-I      intronic chr8:87475796(+) A-I      intronic chr8:87475665(+) A-I      intronic chr8:87477824(+) A-I      intronic chr8:87477782(+) A-I      intronic chr8:87434047(+) A-I      intronic chr8:87405497(+) A-I      intronic chr8:87399792(+) A-I      intronic chr8:87451608(+) A-I      intronic chr8:87376921(+) A-I      intronic chr8:87476874(+) A-I      intronic chr8:87475735(+) A-I      intronic chr8:87360577(+) A-I      intronic chr8:87476830(+) A-I      intronic chr8:87463386(+) A-I      intronic chr8:87476278(+) A-I      intronic chr8:87475715(+) A-I      intronic chr8:87414615(+) A-I      intronic chr8:87451317(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	WWP1	chr8:87476277(+) A-I intron -    22327324 chr8:87394744(+) A-I intron -    21960545 chr8:87394766(+) A-I intron -    21960545 chr8:87395824(+) A-I intron -    21960545 chr8:87405606(+) A-I intron -    21960545 chr8:87406737(+) A-I intron -    21960545 chr8:87406812(+) A-I intron -    21960545 chr8:87407791(+) A-I intron -    21960545 chr8:87407811(+) A-I intron -    21960545 chr8:87407836(+) A-I intron -    21960545 chr8:87407851(+) A-I intron -    21960545 chr8:87408881(+) A-I intron -    21960545 chr8:87448407(+) A-I intron -    21960545 chr8:87449171(+) A-I intron -    21960545 chr8:87449217(+) A-I intron -    21960545 chr8:87451622(+) A-I intron -    21960545 chr8:87475653(+) A-I intron -    21960545 chr8:87475665(+) A-I intron -    21960545 chr8:87476824(+) A-I intron -    21960545 chr8:87476874(+) A-I intron -    21960545 chr8:87477704(+) A-I intron -    21960545 chr8:87477708(+) A-I intron -    21960545 chr8:87477724(+) A-I intron -    21960545 chr8:87371006(+) A-G intron -    22484847 chr8:87394751(+) A-G intron -    22484847 chr8:87395745(+) C-G intron -    22484847 chr8:87400497(+) C-T intron -    22484847 chr8:87414615(+) A-G intron -    22484847 chr8:87442301(+) A-G intron -    22484847 chr8:87442359(+) A-G intron -    22484847 chr8:87442411(+) T-C intron -    22484847 chr8:87442596(+) A-G intron -    22484847 chr8:87442697(+) A-G intron -    22484847 chr8:87444917(+) A-G intron -    22484847 chr8:87473059(+) G-T intron -    22484847 chr8:87473092(+) G-A intron -    22484847 chr8:87475567(+) A-G intron -    22484847 chr8:87475636(+) A-G intron -    22484847 chr8:87475665(+) A-G intron -    22484847 chr8:87475723(+) T-C intron -    22484847 chr8:87476125(+) A-G intron -    22484847 chr8:87476205(+) A-G intron -    22484847 chr8:87476277(+) A-G intron -    22484847 chr8:87476824(+) A-G intron -    22484847 chr8:87476830(+) A-G intron -    22484847 chr8:87477786(+) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	WWP1	chr8:87410586-87410587(+) m6A CDS//exon       24981863 chr8:87410595-87410596(+) m6A CDS//exon       24981863 chr8:87410609-87410610(+) m6A CDS//exon       24981863 chr8:87410629-87410630(+) m6A CDS//exon       24981863 chr8:87410687-87410688(+) m6A CDS//exon       24981863 chr8:87447906-87447907(+) m6A CDS//exon       - chr8:87450827-87450828(+) m6A CDS//exon       - chr8:87479229-87479230(+) m6A 3'UTR//intron       22608085 chr8:87479273-87479274(+) m6A 3'UTR//intron       24981863//27773535//22608085 chr8:87479362-87479363(+) m6A 3'UTR//intron       24981863//22608085 chr8:87479394-87479395(+) m6A 3'UTR//intron       24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1305	Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	WWP1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-1305	Panobinostat       6918837 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Paclitaxel       36314 Sorafenib       216239 5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120 Dovitinib       135398510 Crizotinib       11626560

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1305
Interactor2: WWP1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).