Detail Information

Basic Information:


  VIRBase ID:  

HHID00013295

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1305:           KDELR1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-1305 KDELR1
miRBase
Accession/Entrez ID		 MIMAT0005893 10945
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ERD2//ERD2.1//HDEL//PM23

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-1305
rs1391055872 chr4:182169359    G/A
rs1460502740 chr4:182169360    A/G
rs190183451 chr4:182169358    G/A
rs760149578 chr4:182169357    G/T
rs774577022 chr4:182169356    T/C
rs911409575 chr4:182169355    A/C
rs911409575 chr4:182169355    A/G
rs931724077 chr4:182169352    C/G
rs971149992 chr4:182169361    G/A
rs985999312 chr4:182169354    A/G
rs1192955520 chr4:182169349    A/G
rs1240810346 chr4:182169350    C/A
rs1240810346 chr4:182169350    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR KDELR1
chr19:48889469(-) A-I      intronic
chr19:48889487(-) A-I      intronic
chr19:48892392(-) A-I      intronic
chr19:48892403(-) A-I      intronic
chr19:48892407(-) A-I      intronic
chr19:48892415(-) A-I      intronic
chr19:48892427(-) A-I      intronic
chr19:48892437(-) A-I      intronic
chr19:48892440(-) A-I      intronic
chr19:48892441(-) A-I      intronic
chr19:48892444(-) A-I      intronic
chr19:48892451(-) A-I      intronic
chr19:48889483(-) A-I      intronic
chr19:48889474(-) A-I      intronic
chr19:48888196(-) A-I      intronic
chr19:48888229(-) A-I      intronic
chr19:48891886(-) A-I      intronic
chr19:48891896(-) A-I      intronic
chr19:48890891(-) A-I      intronic
chr19:48890080(-) A-I      intronic
chr19:48890209(-) A-I      intronic
chr19:48890241(-) A-I      intronic
chr19:48890246(-) A-I      intronic
chr19:48890759(-) A-I      intronic
chr19:48888235(-) A-I      intronic
chr19:48888236(-) A-I      intronic
chr19:48888282(-) A-I      intronic
chr19:48891795(-) A-I      intronic
chr19:48889577(-) A-I      intronic
chr19:48889790(-) A-I      intronic
chr19:48889810(-) A-I      intronic
chr19:48889875(-) A-I      intronic
chr19:48889883(-) A-I      intronic
chr19:48889575(-) A-I      intronic
chr19:48889825(-) A-I      intronic
chr19:48890216(-) A-I      intronic
chr19:48889500(-) A-I      intronic
chr19:48889443(-) A-I      intronic
chr19:48889843(-) A-I      intronic
chr19:48890689(-) A-I      intronic
chr19:48889977(-) A-I      intronic
chr19:48890719(-) A-I      intronic
chr19:48890790(-) A-I      intronic
chr19:48890242(-) A-I      intronic
chr19:48890135(-) A-I      intronic
chr19:48889542(-) A-I      intronic
chr19:48890827(-) A-I      intronic
chr19:48889509(-) A-I      intronic
chr19:48889982(-) A-I      intronic
chr19:48888272(-) A-I      intronic
chr19:48890718(-) A-I      intronic
chr19:48889540(-) A-I      intronic
chr19:48890817(-) A-I      intronic
chr19:48890862(-) A-I      intronic
chr19:48889488(-) A-I      intronic
chr19:48890206(-) A-I      intronic
chr19:48888181(-) A-I      intronic
chr19:48890167(-) A-I      intronic
chr19:48889567(-) A-I      intronic
chr19:48890228(-) A-I      intronic
chr19:48889974(-) A-I      intronic
chr19:48889990(-) A-I      intronic
chr19:48889878(-) A-I      intronic
chr19:48890776(-) A-I      intronic
chr19:48890161(-) A-I      intronic
chr19:48889842(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED KDELR1
chr19:48889842(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase KDELR1
chr19:48885831-48885832(-) m6A 3'UTR       27773535
chr19:48885846-48885847(-) m6A 3'UTR       27773535
chr19:48885879-48885880(-) m6A 3'UTR       27773535
chr19:48886096-48886097(-) m6A 3'UTR       24981863//26404942//27773535
chr19:48886146-48886147(-) m6A 3'UTR       24981863//26404942//27773535
chr19:48886337-48886338(-) m6A 3'UTR       27773535
chr19:48886369-48886370(-) m6A 3'UTR       27773535
chr19:48886402-48886403(-) m6A 3'UTR       27773535
chr19:48886491-48886492(-) Am 3'UTR       -
chr19:48893723-48893724(-) m6A 5'UTR//CDS//exon       27773535
chr19:48893787-48893788(-) m6A 5'UTR//intron       27773535
chr19:48894098-48894099(-) m6A 5'UTR//intron       -
chr19:48894109-48894110(-) m6A 5'UTR//intron       24284625//25456834
chr19:48894589-48894590(-) m6A CDS//exon       24284625//25456834//24981863//28052920//27773535
chr19:48894687-48894688(-) m6A 5'UTR//exon       24284625//25456834//24981863//28052920//27773535//27773536//22575960

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-1305
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
KDELR1
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)|K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus HCC cell line (HepG2)|K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-1305
Panobinostat       6918837
Irinotecan       60838
Topotecan       60700
l-685,458       5479543
Palbociclib       5330286
Paclitaxel       36314
Sorafenib       216239
5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120
Dovitinib       135398510
Crizotinib       11626560

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-1305
Interactor2: KDELR1

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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