Basic Information:

  VIRBase ID:  

HHID00013253

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1305:  MIMAT0005893          PSMD14:  NM_005805     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1305	PSMD14
miRBase Accession/Entrez ID	MIMAT0005893	10213
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	PAD1//POH1//RPN11

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1305	rs1391055872 chr4:182169359    G/A rs1460502740 chr4:182169360    A/G rs190183451 chr4:182169358    G/A rs760149578 chr4:182169357    G/T rs774577022 chr4:182169356    T/C rs911409575 chr4:182169355    A/C rs911409575 chr4:182169355    A/G rs931724077 chr4:182169352    C/G rs971149992 chr4:182169361    G/A rs985999312 chr4:182169354    A/G rs1192955520 chr4:182169349    A/G rs1240810346 chr4:182169350    C/A rs1240810346 chr4:182169350    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PSMD14	chr2:162187954(+) A-I      intronic chr2:162187822(+) A-I      intronic chr2:162182722(+) A-I      intronic chr2:162257206(+) A-I      intronic chr2:162179153(+) A-I      intronic chr2:162179123(+) A-I      intronic chr2:162179084(+) A-I      intronic chr2:162179067(+) A-I      intronic chr2:162179062(+) A-I      intronic chr2:162179001(+) A-I      intronic chr2:162178970(+) A-I      intronic chr2:162168890(+) A-I      intronic chr2:162168838(+) A-I      intronic chr2:162168735(+) A-I      intronic chr2:162167752(+) A-I      intronic chr2:162215206(+) A-I      intronic chr2:162215302(+) A-I      intronic chr2:162210891(+) A-I      intronic chr2:162210810(+) A-I      intronic chr2:162210790(+) A-I      intronic chr2:162191283(+) A-I      intronic chr2:162191270(+) A-I      intronic chr2:162190582(+) A-I      intronic chr2:162180099(+) A-I      intronic chr2:162180023(+) A-I      intronic chr2:162179987(+) A-I      intronic chr2:162179920(+) A-I      intronic chr2:162167626(+) A-I      intronic chr2:162179102(+) A-I      intronic chr2:162258893(+) A-I      intronic chr2:162180077(+) A-I      intronic chr2:162202456(+) A-I      intronic chr2:162182823(+) A-I      intronic chr2:162210784(+) A-I      intronic chr2:162182567(+) A-I      intronic chr2:162258966(+) A-I      intronic chr2:162168306(+) A-I      intronic chr2:162198095(+) A-I      intronic chr2:162215217(+) A-I      intronic chr2:162179066(+) A-I      intronic chr2:162221444(+) A-I      intronic chr2:162191326(+) A-I      intronic chr2:162180015(+) A-I      intronic chr2:162179972(+) A-I      intronic chr2:162179163(+) A-I      intronic chr2:162257123(+) A-I      intronic chr2:162258894(+) A-I      intronic chr2:162167585(+) A-I      intronic chr2:162168797(+) A-I      intronic chr2:162178954(+) A-I      intronic chr2:162179175(+) A-I      intronic chr2:162257165(+) A-I      intronic chr2:162200218(+) A-I      intronic chr2:162258968(+) A-I      intronic chr2:162221360(+) A-I      intronic chr2:162260550(+) A-I      intronic chr2:162179959(+) A-I      intronic chr2:162259139(+) A-I      intronic chr2:162179101(+) A-I      intronic chr2:162182725(+) A-I      intronic chr2:162180014(+) A-I      intronic chr2:162179018(+) A-I      intronic chr2:162260436(+) A-I      intronic chr2:162200268(+) A-I      intronic chr2:162191352(+) A-I      intronic chr2:162215598(+) A-I      intronic chr2:162200084(+) A-I      intronic chr2:162202421(+) A-I      intronic chr2:162198096(+) A-I      intronic chr2:162259098(+) A-I      intronic chr2:162167700(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PSMD14	chr2:162183118(+) A-G intron -    22484847 chr2:162167700(+) A-G intron -    22484847 chr2:162168306(+) A-G intron -    22484847 chr2:162168309(+) A-G intron -    22484847 chr2:162168741(+) A-G intron -    22484847 chr2:162168797(+) A-G intron -    22484847 chr2:162178954(+) A-G intron -    22484847 chr2:162179018(+) A-G intron -    22484847 chr2:162179101(+) A-G intron -    22484847 chr2:162179102(+) A-G intron -    22484847 chr2:162179136(+) A-G intron -    22484847 chr2:162179140(+) A-G intron -    22484847 chr2:162179162(+) A-G intron -    22484847 chr2:162179163(+) A-G intron -    22484847 chr2:162179175(+) A-G intron -    22484847 chr2:162179958(+) A-G intron -    22484847 chr2:162180009(+) A-G intron -    22484847 chr2:162180015(+) A-G intron -    22484847 chr2:162180021(+) A-G intron -    22484847 chr2:162180077(+) A-G intron -    22484847 chr2:162182567(+) A-G intron -    22484847 chr2:162182651(+) A-G intron -    22484847 chr2:162182707(+) A-G intron -    22484847 chr2:162182725(+) A-G intron -    22484847 chr2:162182731(+) A-G intron -    22484847 chr2:162182742(+) A-G intron -    22484847 chr2:162190629(+) A-G intron -    22484847 chr2:162201857(+) G-A intron -    22484847 chr2:162202456(+) A-G intron -    22484847 chr2:162202654(+) G-A intron -    22484847 chr2:162215207(+) A-G intron -    22484847 chr2:162215217(+) A-G intron -    22484847 chr2:162215598(+) A-G intron -    22484847 chr2:162215617(+) A-T intron -    22484847 chr2:162253529(+) G-A intron -    22484847 chr2:162259094(+) A-G intron -    22484847 chr2:162260594(+) C-T intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PSMD14	chr2:162164812-162164813(+) m6A 5'UTR       25456834 chr2:162164862-162164863(+) m6A 5'UTR       25456834//24981863 chr2:162164921-162164922(+) m6A 5'UTR       24981863 chr2:162164929-162164930(+) m6A 5'UTR       24981863 chr2:162165005-162165006(+) m6A 5'UTR//exon       24981863 chr2:162165072-162165073(+) m6A 5'UTR//exon       24981863 chr2:162165120-162165121(+) m6A 5'UTR//intron       24981863 chr2:162224411-162224412(+) m6A CDS       22575960 chr2:162226677-162226678(+) Cm CDS       - chr2:162226680-162226681(+) m6A CDS       27773535//22575960 chr2:162237928-162237929(+) m6A exon//intron       27773535 chr2:162242024-162242025(+) m6A CDS//exon       26404942//27773535 chr2:162242030-162242031(+) m6A CDS//exon       26404942//27773535 chr2:162242036-162242037(+) m6A CDS//exon       26404942//27773535 chr2:162242065-162242066(+) m6A CDS//exon       26404942//27773535 chr2:162247628-162247629(+) m6A CDS//exon       26404942//27773535 chr2:162247633-162247634(+) m6A CDS//exon       26404942//27773535 chr2:162247676-162247677(+) m6A CDS//exon       26404942//27773535 chr2:162247682-162247683(+) m6A CDS//exon       26404942//27773535 chr2:162251640-162251641(+) m6A CDS//exon       27773535 chr2:162251650-162251651(+) m6A CDS//exon       27773535 chr2:162251659-162251660(+) m6A CDS//exon       27773535 chr2:162264043-162264044(+) m6A exon//intron       27773535 chr2:162264086-162264087(+) m6A exon//intron       24981863//27773535 chr2:162264115-162264116(+) m6A exon//intron       24981863//27773535 chr2:162265320-162265321(+) m6A exon//intron       26404942 chr2:162265379-162265380(+) m6A CDS//exon       22575960 chr2:162267835-162267836(+) m6A CDS//exon       22575960 chr2:162268015-162268016(+) m6A 3'UTR//exon       27773535 chr2:162268132-162268133(+) m6A 3'UTR//exon       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1305	Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	PSMD14	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-1305	Panobinostat       6918837 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Paclitaxel       36314 Sorafenib       216239 5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120 Dovitinib       135398510 Crizotinib       11626560

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1305
Interactor2: PSMD14

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).