Detail Information

Basic Information:


  VIRBase ID:  

HHID00013216

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1305:           BCLAF1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-1305 BCLAF1
miRBase
Accession/Entrez ID		 MIMAT0005893 9774
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - bK211L9.1//BTF

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-1305
rs1391055872 chr4:182169359    G/A
rs1460502740 chr4:182169360    A/G
rs190183451 chr4:182169358    G/A
rs760149578 chr4:182169357    G/T
rs774577022 chr4:182169356    T/C
rs911409575 chr4:182169355    A/C
rs911409575 chr4:182169355    A/G
rs931724077 chr4:182169352    C/G
rs971149992 chr4:182169361    G/A
rs985999312 chr4:182169354    A/G
rs1192955520 chr4:182169349    A/G
rs1240810346 chr4:182169350    C/A
rs1240810346 chr4:182169350    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR BCLAF1
chr6:136607070(-) A-I      intronic
chr6:136585549(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase BCLAF1
chr6:136578085-136578086(-) m6A 3'UTR       27773535
chr6:136580764-136580765(-) m6A 3'UTR//intron       24981863
chr6:136580775-136580776(-) m6A 3'UTR//intron       24981863
chr6:136580780-136580781(-) m6A 3'UTR//intron       24981863
chr6:136580790-136580791(-) m6A 3'UTR//intron       24981863
chr6:136580803-136580804(-) m6A 3'UTR//intron       24981863
chr6:136580852-136580853(-) m6A 3'UTR//intron       24981863
chr6:136582081-136582082(-) m6A 3'UTR//exon//intron       27773535
chr6:136582215-136582216(-) m6A 3'UTR//exon       24981863//28052920//27773535//22608085
chr6:136582421-136582422(-) m6A 3'UTR//CDS//exon       24209618//24981863//28052920//27773535//27371828//22608085
chr6:136582449-136582450(-) m6A 3'UTR//CDS//exon       24209618//24981863//28052920//27773535//27371828//22608085
chr6:136582497-136582498(-) m6A 3'UTR//CDS//exon       24209618//24981863//28052920//27773535//27371828//22608085
chr6:136588223-136588224(-) m6A 3'UTR//CDS//exon//intron       24981863//27773535//27371828//22608085
chr6:136588251-136588252(-) m6A 3'UTR//CDS//exon//intron       24981863//27773535//27371828
chr6:136588267-136588268(-) m6A 3'UTR//CDS//exon//intron       24981863//27773535//27371828
chr6:136589304-136589305(-) m6A 3'UTR//CDS//exon       27773535
chr6:136589361-136589362(-) m6A 3'UTR//CDS//exon       27773535
chr6:136589473-136589474(-) m6A 3'UTR//CDS//exon//intron       24981863//27773535
chr6:136589709-136589710(-) m6A exon//intron       27773535
chr6:136589731-136589732(-) m6A exon//intron       27773535
chr6:136589736-136589737(-) m6A exon//intron       27773535
chr6:136589764-136589765(-) m6A exon//intron       27773535
chr6:136590561-136590562(-) m6A exon//intron       24981863
chr6:136590617-136590618(-) m6A 3'UTR//CDS//exon       24981863//27773535
chr6:136594254-136594255(-) m6A 3'UTR//CDS//exon       27773535
chr6:136596818-136596819(-) m6A 3'UTR//CDS       27773535
chr6:136597142-136597143(-) m6A CDS//intron       24284625//24981863//27773535//22608085
chr6:136597182-136597183(-) m6A CDS//intron       24284625//24981863//27773535//22608085
chr6:136597217-136597218(-) m6A CDS//intron       24284625//24209618//24981863//28052920//27773535//22608085
chr6:136597272-136597273(-) m6A CDS//intron       24284625//24209618//24981863//28052920//27773535//22608085
chr6:136597282-136597283(-) m6A CDS//intron       24284625//24209618//24981863//28052920//27773535//22575960//22608085
chr6:136597357-136597358(-) m6A CDS//intron       24284625//24209618//24981863//28052920//27773535//27371828//22575960//22608085
chr6:136597435-136597436(-) m6A CDS//intron       24284625//24209618//24981863//28052920//27773535//27371828//22575960//22608085
chr6:136597449-136597450(-) m6A CDS//intron       24284625//24209618//24981863//28052920//27773535//27371828//22575960//22608085
chr6:136597489-136597490(-) m6A CDS//intron       24284625//24981863//27773535//27371828//22608085
chr6:136599021-136599022(-) m6A CDS       24284625//27773535//27371828
chr6:136599030-136599031(-) m6A CDS       24284625//27773535//27371828
chr6:136599108-136599109(-) m6A CDS       27773535
chr6:136599442-136599443(-) m6A CDS       24284625//25456834//24981863//28052920//27773535//22608085
chr6:136599460-136599461(-) m6A CDS       24284625//25456834//24981863//28052920//27773535//22608085
chr6:136599502-136599503(-) m6A CDS       24284625//25456834//24981863//28052920//27773535//22608085
chr6:136599526-136599527(-) m6A CDS       24284625//25456834//24981863//28052920//27773535//22608085
chr6:136603756-136603757(-) m6A 5'UTR//exon       24284625
chr6:136610869-136610870(-) m6A 5'UTR//exon       24284625//24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-1305
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
BCLAF1
Chromatin HCC cell line (HepG2)|K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm HCC cell line (HepG2)|K562 cells     -
Nucleus Colon cancer cells     24393600
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352

Related Drug Information:


Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-1305
Panobinostat       6918837
Irinotecan       60838
Topotecan       60700
l-685,458       5479543
Palbociclib       5330286
Paclitaxel       36314
Sorafenib       216239
5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120
Dovitinib       135398510
Crizotinib       11626560

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-1305
Interactor2: BCLAF1

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT//miRDB//Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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