Detail Information

Basic Information:


  VIRBase ID:  

HHID00013150

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1305:           DEK:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-1305 DEK
miRBase
Accession/Entrez ID		 MIMAT0005893 7913
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - D6S231E

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-1305
rs1391055872 chr4:182169359    G/A
rs1460502740 chr4:182169360    A/G
rs190183451 chr4:182169358    G/A
rs760149578 chr4:182169357    G/T
rs774577022 chr4:182169356    T/C
rs911409575 chr4:182169355    A/C
rs911409575 chr4:182169355    A/G
rs931724077 chr4:182169352    C/G
rs971149992 chr4:182169361    G/A
rs985999312 chr4:182169354    A/G
rs1192955520 chr4:182169349    A/G
rs1240810346 chr4:182169350    C/A
rs1240810346 chr4:182169350    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR DEK
chr6:18238342(-) A-I      intronic
chr6:18250954(-) A-I      intronic
chr6:18257946(-) A-I      intronic
chr6:18257725(-) A-I      intronic
chr6:18238211(-) A-I      intronic
chr6:18238247(-) A-I      intronic
chr6:18254041(-) A-I      intronic
chr6:18254052(-) A-I      intronic
chr6:18238796(-) A-I      intronic
chr6:18238296(-) A-I      intronic
chr6:18238657(-) A-I      intronic
chr6:18238667(-) A-I      intronic
chr6:18254059(-) A-I      intronic
chr6:18254076(-) A-I      intronic
chr6:18238725(-) A-I      intronic
chr6:18238760(-) A-I      intronic
chr6:18254081(-) A-I      intronic
chr6:18238804(-) A-I      intronic
chr6:18238806(-) A-I      intronic
chr6:18238811(-) A-I      intronic
chr6:18238828(-) A-I      intronic
chr6:18239253(-) A-I      intronic
chr6:18239258(-) A-I      intronic
chr6:18239279(-) A-I      intronic
chr6:18240942(-) A-I      intronic
chr6:18240970(-) A-I      intronic
chr6:18242549(-) A-I      intronic
chr6:18250533(-) A-I      intronic
chr6:18250536(-) A-I      intronic
chr6:18238196(-) A-I      intronic
chr6:18238273(-) A-I      intronic
chr6:18254220(-) A-I      intronic
chr6:18254443(-) A-I      intronic
chr6:18254104(-) A-I      intronic
chr6:18238865(-) A-I      intronic
chr6:18241015(-) A-I      intronic
chr6:18242591(-) A-I      intronic
chr6:18238267(-) A-I      intronic
chr6:18239333(-) A-I      intronic
chr6:18238771(-) A-I      intronic
chr6:18239660(-) A-I      intronic
chr6:18238237(-) A-I      intronic
chr6:18256225(-) A-I      intronic
chr6:18238238(-) A-I      intronic
chr6:18241021(-) A-I      intronic
chr6:18257794(-) A-I      intronic
chr6:18238270(-) A-I      intronic
chr6:18238673(-) A-I      intronic
chr6:18226780(-) A-I      intronic
chr6:18238169(-) A-I      intronic
chr6:18238762(-) A-I      intronic
chr6:18250905(-) A-I      intronic
chr6:18250906(-) A-I      intronic
chr6:18248176(-) A-I      intronic
chr6:18242482(-) A-I      intronic
chr6:18239413(-) A-I      intronic
chr6:18238748(-) A-I      intronic
chr6:18238853(-) A-I      intronic
chr6:18248008(-) A-I      intronic
chr6:18238373(-) A-I      intronic
chr6:18238367(-) A-I      intronic
chr6:18226845(-) A-I      intronic
chr6:18239293(-) A-I      intronic
chr6:18238845(-) A-I      intronic
chr6:18250909(-) A-I      intronic
chr6:18239444(-) A-I      intronic
chr6:18226753(-) A-I      intronic
chr6:18226806(-) A-I      intronic
chr6:18238327(-) A-I      intronic
chr6:18250897(-) A-I      intronic
chr6:18238264(-) A-I      intronic
chr6:18240944(-) A-I      intronic
chr6:18242507(-) A-I      intronic
chr6:18239294(-) A-I      intronic
chr6:18254207(-) A-I      intronic
chr6:18252484(-) A-I      intronic
chr6:18238846(-) A-I      intronic
chr6:18254206(-) A-I      intronic
chr6:18242587(-) A-I      intronic
chr6:18250511(-) A-I      intronic
chr6:18235939(-) A-I      intronic
chr6:18226839(-) A-I      intronic
chr6:18248032(-) A-I      intronic
chr6:18238756(-) A-I      intronic
chr6:18238859(-) A-I      intronic
chr6:18254455(-) A-I      intronic
chr6:18238816(-) A-I      intronic
chr6:18238356(-) A-I      intronic
chr6:18254092(-) A-I      intronic
chr6:18254370(-) A-I      intronic
chr6:18253991(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED DEK
chr6:18253404(-) A-G intron -    22484847
chr6:18238195(-) A-G intron -    22484847
chr6:18238327(-) A-G intron -    22484847
chr6:18238356(-) A-G intron -    22484847
chr6:18238367(-) A-G intron -    22484847
chr6:18238705(-) C-T intron -    22484847
chr6:18238756(-) A-G intron -    22484847
chr6:18238762(-) A-G intron -    22484847
chr6:18238765(-) A-G intron -    22484847
chr6:18238771(-) A-G intron -    22484847
chr6:18238816(-) A-G intron -    22484847
chr6:18238841(-) A-G intron -    22484847
chr6:18238842(-) A-G intron -    22484847
chr6:18238845(-) A-G intron -    22484847
chr6:18238846(-) A-G intron -    22484847
chr6:18239293(-) A-G intron -    22484847
chr6:18239294(-) A-G intron -    22484847
chr6:18239413(-) A-G intron -    22484847
chr6:18242507(-) A-G intron -    22484847
chr6:18248008(-) A-G intron -    22484847
chr6:18250511(-) A-G intron -    22484847
chr6:18253991(-) A-G intron -    22484847
chr6:18254206(-) A-G intron -    22484847
chr6:18254370(-) A-G intron -    22484847
chr6:18254450(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase DEK
chr6:18224868-18224869(-) Gm 3'UTR       -
chr6:18224957-18224958(-) m6A 3'UTR       22575960
chr6:18225010-18225011(-) m6A 3'UTR       24981863//26404942//22575960
chr6:18225063-18225064(-) m6A 3'UTR       24981863//26404942//22575960
chr6:18225097-18225098(-) m6A 3'UTR       24981863//26404942
chr6:18225193-18225194(-) m6A 3'UTR       22575960
chr6:18225231-18225232(-) m6A 3'UTR       22575960
chr6:18225244-18225245(-) m6A 3'UTR       22575960
chr6:18225270-18225271(-) m6A 3'UTR       22575960
chr6:18225917-18225918(-) Tm 3'UTR       -
chr6:18225940-18225941(-) m6A 3'UTR       24981863//26404942//27773535
chr6:18226200-18226201(-) m6A 3'UTR//intron       27773535
chr6:18226206-18226207(-) m6A 3'UTR//intron       27773535
chr6:18226361-18226362(-) m6A 3'UTR//intron       24981863
chr6:18226418-18226419(-) m6A CDS       24981863//27773535
chr6:18236697-18236698(-) m6A CDS       24981863//28052920//27773535//22575960//22608085
chr6:18236747-18236748(-) m6A 3'UTR//CDS       24981863//28052920//27773535//22575960//22608085
chr6:18236775-18236776(-) m6A 3'UTR//CDS       24284625//24981863//28052920//27773535//22575960//22608085
chr6:18236799-18236800(-) m6A 3'UTR//CDS       24284625//24981863//28052920//27773535//22575960//22608085
chr6:18237367-18237368(-) m6A exon//intron       24284625//24981863//28052920//27773535//22608085
chr6:18237378-18237379(-) m6A exon//intron       24284625//24981863//28052920//27773535//22608085
chr6:18237406-18237407(-) m6A exon//intron       24981863//28052920//27773535//22608085
chr6:18237625-18237626(-) m6A 3'UTR//CDS//exon       24981863//28052920//27773535//22575960//22608085
chr6:18237711-18237712(-) m6A 3'UTR//CDS//exon       24981863//28052920//27773535//22575960//22608085
chr6:18237717-18237718(-) m6A 3'UTR//CDS//exon       24981863//28052920//27773535//22575960//22608085
chr6:18237734-18237735(-) m6A 3'UTR//CDS//exon       24981863//28052920//27773535//22575960//22608085
chr6:18244774-18244775(-) m6A CDS//intron       24981863//27773535//22608085
chr6:18244812-18244813(-) m6A CDS//intron       24981863//27773535
chr6:18249893-18249894(-) Am CDS//exon       -
chr6:18249927-18249928(-) m6A CDS//exon       24981863
chr6:18249985-18249986(-) m6A CDS//exon       24981863
chr6:18250017-18250018(-) m6A CDS//exon       24981863
chr6:18250048-18250049(-) m6A CDS//exon       24981863
chr6:18256012-18256013(-) m6A CDS//exon       22575960
chr6:18258207-18258208(-) m6A CDS       24981863//27773535
chr6:18258225-18258226(-) m6A CDS       24981863//27773535
chr6:18258233-18258234(-) m6A CDS       24981863//27773535
chr6:18258279-18258280(-) m6A CDS//intron       24209618//24981863//28052920//27773535//27371828
chr6:18264134-18264135(-) Cm CDS//intron       -
chr6:18264152-18264153(-) m6A CDS//intron       24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960
chr6:18264181-18264182(-) m6A CDS//intron       24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960
chr6:18264258-18264259(-) m6A 5'UTR//intron       24209618//25456834//24981863//27371828//27773536//22575960
chr6:18264371-18264372(-) m6A 5'UTR//intron       24209618//24981863//27773536//22575960
chr6:18264662-18264663(-) m6A 5'UTR       24209618//24981863//27371828//27773536//22575960
chr6:18264713-18264714(-) m6A 5'UTR       24209618//24981863//27371828//27773536//22575960
chr6:18264749-18264750(-) Y 5'UTR       25219674
chr6:18264777-18264778(-) m6A 5'UTR       24209618//24981863//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-1305
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
DEK
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells|K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-1305
Panobinostat       6918837
Irinotecan       60838
Topotecan       60700
l-685,458       5479543
Palbociclib       5330286
Paclitaxel       36314
Sorafenib       216239
5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120
Dovitinib       135398510
Crizotinib       11626560

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-1305
Interactor2: DEK

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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