Detail Information

Basic Information:


  VIRBase ID:  

HHID00013132

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1305:           TP53:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-1305 TP53
miRBase
Accession/Entrez ID		 MIMAT0005893 7157
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - BCC7//BMFS5//LFS1//P53//TRP53

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-1305
rs1391055872 chr4:182169359    G/A
rs1460502740 chr4:182169360    A/G
rs190183451 chr4:182169358    G/A
rs760149578 chr4:182169357    G/T
rs774577022 chr4:182169356    T/C
rs911409575 chr4:182169355    A/C
rs911409575 chr4:182169355    A/G
rs931724077 chr4:182169352    C/G
rs971149992 chr4:182169361    G/A
rs985999312 chr4:182169354    A/G
rs1192955520 chr4:182169349    A/G
rs1240810346 chr4:182169350    C/A
rs1240810346 chr4:182169350    C/T

RNA Editing:


Resource Symbol Editing Position
Lncediting TP53
    chr17: 7588904
    chr17: 7588877
Resource Symbol Editing Position Change Genetic Region
RADAR TP53
chr17:7574250(-) A-I      intronic
chr17:7573520(-) A-I      intronic
chr17:7573351(-) A-I      intronic
chr17:7573387(-) A-I      intronic
chr17:7573391(-) A-I      intronic
chr17:7573398(-) A-I      intronic
chr17:7573399(-) A-I      intronic
chr17:7573478(-) A-I      intronic
chr17:7574292(-) A-I      intronic
chr17:7574227(-) A-I      intronic
chr17:7573369(-) A-I      intronic
chr17:7575291(-) A-I      intronic
chr17:7575306(-) A-I      intronic
chr17:7575453(-) A-I      intronic
chr17:7576230(-) A-I      intronic
chr17:7576261(-) A-I      intronic
chr17:7576264(-) A-I      intronic
chr17:7576361(-) A-I      intronic
chr17:7587661(-) A-I      intronic
chr17:7576380(-) A-I      intronic
chr17:7576396(-) A-I      intronic
chr17:7576405(-) A-I      intronic
chr17:7576421(-) A-I      intronic
chr17:7586541(-) A-I      intronic
chr17:7575466(-) A-I      intronic
chr17:7575516(-) A-I      intronic
chr17:7575536(-) A-I      intronic
chr17:7575592(-) A-I      intronic
chr17:7575608(-) A-I      intronic
chr17:7576437(-) A-I      intronic
chr17:7583952(-) A-I      intronic
chr17:7574403(-) A-I      intronic
chr17:7574462(-) A-I      intronic
chr17:7574463(-) A-I      intronic
chr17:7574479(-) A-I      intronic
chr17:7574730(-) A-I      intronic
chr17:7574756(-) A-I      intronic
chr17:7574767(-) A-I      intronic
chr17:7574782(-) A-I      intronic
chr17:7574800(-) A-I      intronic
chr17:7574811(-) A-I      intronic
chr17:7574821(-) A-I      intronic
chr17:7574826(-) A-I      intronic
chr17:7588904(-) A-I      intronic
chr17:7588877(-) A-I      intronic
chr17:7587669(-) A-I      intronic
chr17:7587624(-) A-I      intronic
chr17:7587598(-) A-I      intronic
chr17:7587574(-) A-I      intronic
chr17:7587205(-) A-I      intronic
chr17:7583956(-) A-I      intronic
chr17:7587199(-) A-I      intronic
chr17:7575775(-) A-I      intronic
chr17:7575868(-) A-I      intronic
chr17:7575939(-) A-I      intronic
chr17:7576110(-) A-I      intronic
chr17:7576184(-) A-I      intronic
chr17:7573279(-) A-I      intronic
chr17:7573315(-) A-I      intronic
chr17:7573355(-) A-I      intronic
chr17:7586686(-) A-I      intronic
chr17:7573435(-) A-I      intronic
chr17:7574228(-) A-I      intronic
chr17:7574305(-) A-I      intronic
chr17:7572048(-) A-I      3'UTR
chr17:7572107(-) A-I      3'UTR
chr17:7571943(-) A-I      3'UTR
chr17:7571926(-) A-I      3'UTR
chr17:7571944(-) A-I      3'UTR
chr17:7574393(-) A-I      intronic
chr17:7586338(-) A-I      intronic
chr17:7587302(-) A-I      intronic
chr17:7574688(-) A-I      intronic
chr17:7574296(-) A-I      intronic
chr17:7587561(-) A-I      intronic
chr17:7587082(-) A-I      intronic
chr17:7574520(-) A-I      intronic
chr17:7584245(-) A-I      intronic
chr17:7587693(-) A-I      intronic
chr17:7574572(-) A-I      intronic
chr17:7587621(-) A-I      intronic
chr17:7575299(-) A-I      intronic
chr17:7576319(-) A-I      intronic
chr17:7574311(-) A-I      intronic
chr17:7584291(-) A-I      intronic
chr17:7573395(-) A-I      intronic
chr17:7574545(-) A-I      intronic
chr17:7575897(-) A-I      intronic
chr17:7587676(-) A-I      intronic
chr17:7587514(-) A-I      intronic
chr17:7587473(-) A-I      intronic
chr17:7587534(-) A-I      intronic
chr17:7587218(-) A-I      intronic
chr17:7574298(-) A-I      intronic
chr17:7585684(-) A-I      intronic
chr17:7587701(-) A-I      intronic
chr17:7573459(-) A-I      intronic
chr17:7573390(-) A-I      intronic
chr17:7587545(-) A-I      intronic
chr17:7582810(-) A-I      intronic
chr17:7574715(-) A-I      intronic
chr17:7575858(-) A-I      intronic
chr17:7573473(-) A-I      intronic
chr17:7574318(-) A-I      intronic
chr17:7587126(-) A-I      intronic
chr17:7572004(-) A-I      3'UTR
chr17:7574265(-) A-I      intronic
chr17:7587660(-) A-I      intronic
chr17:7571913(-) A-I      3'UTR
chr17:7572141(-) A-I      3'UTR
chr17:7587472(-) A-I      intronic
chr17:7575233(-) A-I      intronic
chr17:7573467(-) A-I      intronic
chr17:7572026(-) A-I      3'UTR
chr17:7587671(-) A-I      intronic
chr17:7587663(-) A-I      intronic
chr17:7573334(-) A-I      intronic
chr17:7587200(-) A-I      intronic
chr17:7574341(-) A-I      intronic
chr17:7575528(-) A-I      intronic
chr17:7574913(-) A-I      intronic
chr17:7575356(-) A-I      intronic
chr17:7574407(-) A-I      intronic
chr17:7587537(-) A-I      intronic
chr17:7575244(-) A-I      intronic
chr17:7576064(-) A-I      intronic
chr17:7587301(-) A-I      intronic
chr17:7587668(-) A-I      intronic
chr17:7586352(-) A-I      intronic
chr17:7574783(-) A-I      intronic
chr17:7574517(-) A-I      intronic
chr17:7573472(-) A-I      intronic
chr17:7575465(-) A-I      intronic
chr17:7573360(-) A-I      intronic
chr17:7587190(-) A-I      intronic
chr17:7575947(-) A-I      intronic
chr17:7587198(-) A-I      intronic
chr17:7576006(-) A-I      intronic
chr17:7587499(-) A-I      intronic
chr17:7574757(-) A-I      intronic
chr17:7582804(-) A-I      intronic
chr17:7582053(-) A-I      intronic
chr17:7574539(-) A-I      intronic
chr17:7574258(-) A-I      intronic
chr17:7573454(-) A-I      intronic
chr17:7574354(-) A-I      intronic
chr17:7574328(-) A-I      intronic
chr17:7573361(-) A-I      intronic
chr17:7576027(-) A-I      intronic
chr17:7587525(-) A-I      intronic
chr17:7587645(-) A-I      intronic
chr17:7575777(-) A-I      intronic
chr17:7574547(-) A-I      intronic
chr17:7571931(-) A-I      3'UTR
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TP53
chr17:7587671(-) A-I intron -    22327324
chr17:7572004(-) A-G exon 3'UTR    22484847
chr17:7572148(-) C-T exon 3'UTR    22484847
chr17:7572154(-) C-T exon 3'UTR    22484847
chr17:7572173(-) C-T exon 3'UTR    22484847
chr17:7573360(-) A-G intron -    22484847
chr17:7573361(-) A-G intron -    22484847
chr17:7574354(-) A-G intron -    22484847
chr17:7574547(-) A-G intron -    22484847
chr17:7587198(-) A-G intron -    22484847
chr17:7587301(-) A-G intron -    22484847
chr17:7587302(-) A-G intron -    22484847
chr17:7587472(-) A-G intron -    22484847
chr17:7587645(-) A-G intron -    22484847
chr17:7587663(-) A-G intron -    22484847
chr17:7587668(-) A-G intron -    22484847
chr17:7587671(-) A-G intron -    22484847
chr17:7587676(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TP53
chr17:7569558-7569559(-) m6A CDS//intron       24981863//27773535
chr17:7571749-7571750(-) m6A 3'UTR//intron       24981863//27773535
chr17:7571942-7571943(-) m6A 3'UTR//intron       27773535
chr17:7572719-7572720(-) m6A 3'UTR//intron       26404942
chr17:7572771-7572772(-) m6A 3'UTR//intron       -
chr17:7572804-7572805(-) m6A 3'UTR//intron       -
chr17:7572843-7572844(-) m6A 3'UTR//intron       -
chr17:7572930-7572931(-) m6A 3'UTR//CDS//intron       27773535//27371828
chr17:7572949-7572950(-) m6A 3'UTR//CDS//intron       27773535//27371828
chr17:7572962-7572963(-) m6A 3'UTR//CDS//intron       27773535//27371828
chr17:7573979-7573980(-) m6A 3'UTR//CDS//intron       27371828
chr17:7576546-7576547(-) m6A 3'UTR//CDS//intron       27371828
chr17:7576650-7576651(-) m6A CDS//intron       24981863//27371828
chr17:7576882-7576883(-) m6A CDS//intron       24981863//27371828//27773536
chr17:7577095-7577096(-) m6A CDS//intron       -
chr17:7578511-7578512(-) m6A 5'UTR//CDS//exon       24284625//27773535
chr17:7579334-7579335(-) m6A CDS//exon//intron       24284625
chr17:7579382-7579383(-) m6A CDS//exon//intron       24284625
chr17:7579516-7579517(-) m6A CDS//exon//intron       24284625//22575960
chr17:7579533-7579534(-) m6A CDS//exon//intron       24284625//22575960
chr17:7579709-7579710(-) m6A 5'UTR//CDS//exon//intron       24284625//22575960
chr17:7579720-7579721(-) m6A 5'UTR//CDS//exon//intron       24284625//22575960
chr17:7579840-7579841(-) m6A 5'UTR//CDS//exon//intron       24284625//27371828//27773536
chr17:7579850-7579851(-) m6A 5'UTR//CDS//exon//intron       24284625//27371828//27773536
chr17:7579860-7579861(-) m6A 5'UTR//CDS//exon//intron       24284625//27371828//27773536
chr17:7579932-7579933(-) m6A 5'UTR//exon//intron       24284625//27371828//27773536
chr17:7580702-7580703(-) m6A 5'UTR//intron       24284625//24981863//27371828//27773536
chr17:7588791-7588792(-) m6A intron       27371828//27773536
chr17:7588861-7588862(-) m6A intron       27371828//27773536
chr17:7588979-7588980(-) m6A intron       24284625//25456834//24981863//27371828//22608085
chr17:7589074-7589075(-) m6A intron       24284625//25456834//24981863//22608085
chr17:7589175-7589176(-) m6A intron       24284625//24981863//27773535//22608085
chr17:7589398-7589399(-) m6A intron       24284625//22608085
chr17:7589550-7589551(-) m6A intron       22608085
chr17:7590754-7590755(-) m6A 5'UTR//exon       24284625//25456834//24981863
chr17:7590831-7590832(-) m6A 5'UTR       25456834//24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-1305
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
TP53
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Membrane HCC cell line (HepG2)|K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-1305
Panobinostat       6918837
Irinotecan       60838
Topotecan       60700
l-685,458       5479543
Palbociclib       5330286
Paclitaxel       36314
Sorafenib       216239
5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120
Dovitinib       135398510
Crizotinib       11626560

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-1305
Interactor2: TP53

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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