Detail Information

Basic Information:


  VIRBase ID:  

HHID00013114

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1305:           STAT1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-1305 STAT1
miRBase
Accession/Entrez ID		 MIMAT0005893 6772
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CANDF7//IMD31A//IMD31B//IMD31C//ISGF-3//STAT91

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-1305
rs1391055872 chr4:182169359    G/A
rs1460502740 chr4:182169360    A/G
rs190183451 chr4:182169358    G/A
rs760149578 chr4:182169357    G/T
rs774577022 chr4:182169356    T/C
rs911409575 chr4:182169355    A/C
rs911409575 chr4:182169355    A/G
rs931724077 chr4:182169352    C/G
rs971149992 chr4:182169361    G/A
rs985999312 chr4:182169354    A/G
rs1192955520 chr4:182169349    A/G
rs1240810346 chr4:182169350    C/A
rs1240810346 chr4:182169350    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR STAT1
chr2:191857962(-) A-I      intronic
chr2:191857972(-) A-I      intronic
chr2:191857971(-) A-I      intronic
chr2:191857965(-) A-I      intronic
chr2:191858040(-) A-I      intronic
chr2:191858035(-) A-I      intronic
chr2:191858030(-) A-I      intronic
chr2:191858014(-) A-I      intronic
chr2:191858007(-) A-I      intronic
chr2:191857990(-) A-I      intronic
chr2:191857979(-) A-I      intronic
chr2:191858012(-) A-I      intronic
chr2:191876684(-) A-I      intronic
chr2:191876676(-) A-I      intronic
chr2:191859560(-) A-I      intronic
chr2:191876709(-) A-I      intronic
chr2:191876773(-) A-I      intronic
chr2:191876704(-) A-I      intronic
chr2:191876242(-) A-I      intronic
chr2:191857558(-) A-I      intronic
chr2:191836430(-) A-I      intronic
chr2:191876922(-) A-I      intronic
chr2:191876966(-) A-I      intronic
chr2:191877060(-) A-I      intronic
chr2:191876947(-) A-I      intronic
chr2:191877079(-) A-I      intronic
chr2:191877055(-) A-I      intronic
chr2:191877134(-) A-I      intronic
chr2:191877059(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED STAT1
chr2:191858027(-) A-I intron -    22327324
chr2:191858032(-) A-I intron -    22327324
chr2:191858041(-) A-I intron -    22327324
chr2:191858235(-) A-I intron -    22327324
chr2:191876242(-) A-I intron -    22327324
chr2:191876947(-) A-I intron -    22327324
chr2:191857252(-) A-I intron -    21960545
chr2:191857334(-) A-I intron -    21960545
chr2:191836426(-) A-G intron -    22484847
chr2:191836428(-) G-A intron -    22484847
chr2:191836430(-) A-G intron -    22484847
chr2:191836434(-) G-A intron -    22484847
chr2:191836438(-) G-A intron -    22484847
chr2:191836442(-) A-G intron -    22484847
chr2:191853286(-) G-T intron -    22484847
chr2:191863398(-) G-T intron -    22484847
chr2:191863399(-) T-G intron -    22484847
chr2:191863407(-) G-T intron -    22484847
chr2:191863408(-) T-G intron -    22484847
chr2:191876242(-) A-G intron -    22484847
chr2:191876253(-) A-G intron -    22484847
chr2:191876277(-) A-G intron -    22484847
chr2:191876917(-) A-G intron -    22484847
chr2:191876922(-) A-G intron -    22484847
chr2:191876947(-) A-G intron -    22484847
chr2:191876966(-) A-G intron -    22484847
chr2:191877055(-) A-G intron -    22484847
chr2:191877059(-) A-G intron -    22484847
chr2:191877060(-) A-G intron -    22484847
chr2:191877079(-) A-G intron -    22484847
chr2:191877134(-) A-G intron -    22484847
chr2:191876283(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase STAT1
chr2:191833967-191833968(-) Y 3'UTR//intron       26075521
chr2:191834403-191834404(-) m6A 3'UTR//intron       26404942
chr2:191835032-191835033(-) m6A 3'UTR//intron       22575960
chr2:191835175-191835176(-) m6A 3'UTR//intron       22575960
chr2:191841603-191841604(-) m6A 3'UTR//CDS       26404942
chr2:191850374-191850375(-) m6A 3'UTR//CDS       22575960
chr2:191851628-191851629(-) m6A 3'UTR//CDS       22575960
chr2:191856027-191856028(-) m6A 3'UTR//CDS       26404942
chr2:191859822-191859823(-) m6A 3'UTR//CDS       26404942//27773535
chr2:191859840-191859841(-) m6A 3'UTR//CDS       26404942//27773535
chr2:191859860-191859861(-) m6A 3'UTR//CDS       26404942//27773535
chr2:191859878-191859879(-) m6A 3'UTR//CDS       26404942//27773535
chr2:191862584-191862585(-) m6A 3'UTR//CDS       24981863//26404942//27773535
chr2:191862640-191862641(-) m6A 3'UTR//CDS       24981863//28052920//26404942//27773535
chr2:191862661-191862662(-) m6A 3'UTR//CDS       24981863//28052920//26404942//27773535//22575960
chr2:191862691-191862692(-) m6A 3'UTR//CDS       24981863//28052920//26404942//27773535//22575960
chr2:191862990-191862991(-) m6A CDS//intron       24981863//28052920//27773535//22575960
chr2:191862996-191862997(-) m6A CDS//intron       24981863//28052920//27773535//22575960
chr2:191863025-191863026(-) m6A CDS//intron       24981863//28052920//27773535//22575960
chr2:191864356-191864357(-) m6A CDS       24981863//28052920//27773535//22575960
chr2:191864366-191864367(-) m6A CDS       24981863//28052920//27773535//22575960
chr2:191865809-191865810(-) m6A CDS       24981863//28052920//26404942//27773535//22575960
chr2:191865851-191865852(-) m6A CDS       24981863//26404942//27773535//22575960
chr2:191878510-191878511(-) m6A 5'UTR//intron       27371828
chr2:191878788-191878789(-) Y 5'UTR//intron       25219674
chr2:191878824-191878825(-) m6A 5'UTR//intron       25456834//24981863//27371828//27773536
chr2:191878831-191878832(-) m6A 5'UTR//intron       25456834//24981863//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-1305
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
STAT1
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)     -
Nucleoplasm K562 cells     -
Nucleus Colon cancer cells     24393600
Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -
Ribosome HEK-293 cells     22199352

Related Drug Information:


Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-1305
Panobinostat       6918837
Irinotecan       60838
Topotecan       60700
l-685,458       5479543
Palbociclib       5330286
Paclitaxel       36314
Sorafenib       216239
5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120
Dovitinib       135398510
Crizotinib       11626560

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-1305
Interactor2: STAT1

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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